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The map label for this gene is hisC

Identifier: 161870437

GI number: 161870437

Start: 1514452

End: 1515549

Strand: Direct

Name: hisC

Synonym: NMCC_1486

Alternate gene names: 161870437

Gene position: 1514452-1515549 (Clockwise)

Preceding gene: 161870436

Following gene: 229597117

Centisome position: 70.33

GC content: 56.47

Gene sequence:

>1098_bases
ATGAAATCCGTCCGCTCCTTCATCCGCGACGACATACAAGCTATGTCGGCATATCAGATTGCCGACGTTCCGCCCGGCTT
TGCCAAACTCGATTCGATGGAAAGTCCCGTCCACCCTTTTGCCGGACATGAAACGCTGTTGCAGGAATGGCAGGCACGGC
TTGCCGCCGCGCCCATCCATCTTTACCCCAATCCCTCCGGCAGCGGTTTACAGGAAGCATTACGTTCGGCGTTCGACATT
CCCGACTGCGCCGACATCGCGCTGGGCAACGGCTCGGACGAGCTGATACAGTTCATCACGATGCTGACCGCCAAACCGGG
CGCGGCAATGTTGGCAGCCGAACCCAGTTTCGTCATGTACCGCCACAACGCCGCGCTGTACGGCATGGATTATGTCGGCG
TTCCACTGAACGGAGATTTCACCCTCAACCTGCCCGCCGTCCTCGAAGCCGTCAGGAAGCACCGCCCTGCCCTGACCTTT
ATCGCCTACCCCAACAACCCCACCGGCGTATGTTTCACGCGTGCCGAAATCGAAGCCGTCATCGAAGCTTCAGACGGCAT
CGTCGTCGTCGACGAAGCCTACGGCGCATTCAACGGCGACAGCTTCCTGCCGCAGGCGGGCAGCATTCCCAACCTCATCG
TCATGCGTACCGTCAGCAAAATCGGTTTTGCCGGACTGCGTATCGGCTATGCGGCAGGCTGTCCCGAAGTCATCGGCGAA
CTGCAAAAAATCCTGCCGCCCTACAATATGAACCAACTGAGCCTGACCACCGCCAAACTCGCCCTGCAACACTACGGCAT
CATCTCTGCCAACATCGACAGCCTGAAAAACGAACGCGAACGGATGTTCGCCGAATTGGGCAAAATATGCCGTCTGAACA
CCTTTCCAAGTCAGGCAAACTTCATTACCATACGCGTACCCGATGCCGATTTGTTGTTTGACACGCTCAAACAAAACCGC
ATCTTGGTTAAAAAACTGCATGGCGCGCACCCGCTTTTGGAACACTGCCTGCGCATTACCGTAGGCAGCCCCGCACAAAA
CGATGCCGTTCTCAACATCATTCGCCAACTTTACTGCCAACCAACGGATTTCCTATGA

Upstream 100 bases:

>100_bases
ACACGGCGAAAGCCTGACCGCCCACGCCCGCGCGGCAGAGTTCCGTATGAAATAATGCCGAAACGGCGTACAGGCATATT
CCAACCATTAAGGAAACACG

Downstream 100 bases:

>100_bases
ATTTGACTAAAACACAACGCCAACTGCACAACTTTCTGACCCTCGCCCAAGAAGCAGGTTCGCTGTCCAAGCTCGCCAAA
CTCTGCGGCTACCGTACCCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIHLYPNPSGSGLQEALRSAFDI
PDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMYRHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTF
IAYPNNPTGVCFTRAEIEAVIEASDGIVVVDEAYGAFNGDSFLPQAGSIPNLIVMRTVSKIGFAGLRIGYAAGCPEVIGE
LQKILPPYNMNQLSLTTAKLALQHYGIISANIDSLKNERERMFAELGKICRLNTFPSQANFITIRVPDADLLFDTLKQNR
ILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQPTDFL

Sequences:

>Translated_365_residues
MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIHLYPNPSGSGLQEALRSAFDI
PDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMYRHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTF
IAYPNNPTGVCFTRAEIEAVIEASDGIVVVDEAYGAFNGDSFLPQAGSIPNLIVMRTVSKIGFAGLRIGYAAGCPEVIGE
LQKILPPYNMNQLSLTTAKLALQHYGIISANIDSLKNERERMFAELGKICRLNTFPSQANFITIRVPDADLLFDTLKQNR
ILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQPTDFL
>Mature_365_residues
MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIHLYPNPSGSGLQEALRSAFDI
PDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMYRHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTF
IAYPNNPTGVCFTRAEIEAVIEASDGIVVVDEAYGAFNGDSFLPQAGSIPNLIVMRTVSKIGFAGLRIGYAAGCPEVIGE
LQKILPPYNMNQLSLTTAKLALQHYGIISANIDSLKNERERMFAELGKICRLNTFPSQANFITIRVPDADLLFDTLKQNR
ILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQPTDFL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=283, Percent_Identity=30.0353356890459, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322075, Length=336, Percent_Identity=29.4642857142857, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_NEIM0 (A9M185)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001599609.1
- ProteinModelPortal:   A9M185
- SMR:   A9M185
- EnsemblBacteria:   EBNEIT00000011591
- GeneID:   5795997
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_1486
- GeneTree:   EBGT00050000020826
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- ProtClustDB:   PRK04870
- BioCyc:   NMEN374833:NMCC_1486-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39848; Mature: 39848

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIH
CHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
LYPNPSGSGLQEALRSAFDIPDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMY
ECCCCCCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHCCCCCEEEECCCCEEEE
RHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTFIAYPNNPTGVCFTRAEIEAV
ECCCEEEECCEEECCCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHEE
IEASDGIVVVDEAYGAFNGDSFLPQAGSIPNLIVMRTVSKIGFAGLRIGYAAGCPEVIGE
EECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHEECHHCCCHHHHHH
LQKILPPYNMNQLSLTTAKLALQHYGIISANIDSLKNERERMFAELGKICRLNTFPSQAN
HHHHCCCCCCCCEEHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FITIRVPDADLLFDTLKQNRILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQ
EEEEEECCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHCC
PTDFL
CCCCC
>Mature Secondary Structure
MKSVRSFIRDDIQAMSAYQIADVPPGFAKLDSMESPVHPFAGHETLLQEWQARLAAAPIH
CHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
LYPNPSGSGLQEALRSAFDIPDCADIALGNGSDELIQFITMLTAKPGAAMLAAEPSFVMY
ECCCCCCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHCCCCCEEEECCCCEEEE
RHNAALYGMDYVGVPLNGDFTLNLPAVLEAVRKHRPALTFIAYPNNPTGVCFTRAEIEAV
ECCCEEEECCEEECCCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHEE
IEASDGIVVVDEAYGAFNGDSFLPQAGSIPNLIVMRTVSKIGFAGLRIGYAAGCPEVIGE
EECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHEECHHCCCHHHHHH
LQKILPPYNMNQLSLTTAKLALQHYGIISANIDSLKNERERMFAELGKICRLNTFPSQAN
HHHHCCCCCCCCEEHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FITIRVPDADLLFDTLKQNRILVKKLHGAHPLLEHCLRITVGSPAQNDAVLNIIRQLYCQ
EEEEEECCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHCC
PTDFL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA