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The map label for this gene is lysC [H]

Identifier: 161870361

GI number: 161870361

Start: 1428182

End: 1429192

Strand: Reverse

Name: lysC [H]

Synonym: NMCC_1405

Alternate gene names: 161870361

Gene position: 1429192-1428182 (Counterclockwise)

Preceding gene: 161870362

Following gene: 161870356

Centisome position: 66.37

GC content: 54.1

Gene sequence:

>1011_bases
TTGTCCACCGGCGAACAAGTAACCATCGGCCTTTTGGCGATGGCATTGAAAGACATCGGCGTGGAAGCCAAAAGCTACAC
CGGCTGGCAGGTCGCCCTCAAAACCGATACCGCCCACACCAAAGCCCGCATCGAAAGCATTGATGACGAAAAAATGCGTG
CCGACCTTGCCGCCGGCAAAGTCGTCATCGTCGCCGGTTTCCAAGGCATCAGCAGCGAAGGCGACATTTCCACGCTCGGA
CGCGGCGGCTCCGACACCTCCGCCGTTGCGCTCGCCGCAGCCCTCAAAGCAGACGAATGCCAAATCTATACCGACGTGGA
CGGCGTTTACACCACCGACCCCCGCGTCGTACCCGAAGCGCGCCGCATGGATACGGTTACATTTGAAGAAATGATCGAAC
TGGCAAGCCTCGGTTCGAAAGTTTTGCAAATCCGTTCAGTAGAATTTGCCGGAAAATACAAAGTGCGCCTGCGCGTACTG
AGCAGCCTGCAAGACGGCGGCAACGGCACCTTAATTACCTTTGAAGAGGACGACAACATGGAAAGAGCTGCCGTAACCGG
TATCGCATTCGACAAAAACCAAGCCCGCATCAACGTGCGCGGTGTGCCCGATAAGCCCGGCGTCGCCTATCAGATTTTAG
GCGCGGTTGCCGATGCCAACATCGAAGTCGATATGATTATCCAAAATGTCGGCAGCGAAGGCACAACCGATTTTTCCTTT
ACCGTACCGCGCGGCGATTACAAGCAGACTTTGGAAATCCTGTCGGAACGCCAAGACAGTATCGGCGCGGCTTCTATTGA
TGGCGACGACACCGTATGCAAAGTCTCCGCAGTCGGTTTGGGTATGCGTTCGCACGTCGGTGTAGCCGCCAAAATCTTCC
GCACGCTCGCCGAAGAGGGTATCAACATCCAAATGATTTCCACCTCCGAAATCAAAGTTTCCGTATTGATTGATGAAAAA
TACATGGAACTGGCAACCAGGGTATTGCATAAAGCCTTTAATTTGGGCTGA

Upstream 100 bases:

>100_bases
CGTCGTCGTCGTATCCGCCATGAGCGGTGAAACCAACCGCCTGGTCGCGTTGGCGCACGAAATGCAGGAGCATCCCGATC
CGCGCGAATTGGACGTGGTT

Downstream 100 bases:

>100_bases
TGTTTCACGGTTTGAAACGGACAACGGCACTGCCTTTATCGGGCAGTGCCGTTTTGTCTGCCGCCCGAATGTTCGGACGG
CATATTTTGACTTTGGAACA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSTGEQVTIGLLAMALKDIGVEAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLAAGKVVIVAGFQGISSEGDISTLG
RGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRLRVL
SSLQDGGNGTLITFEEDDNMERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGSEGTTDFSF
TVPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEGINIQMISTSEIKVSVLIDEK
YMELATRVLHKAFNLG

Sequences:

>Translated_336_residues
MSTGEQVTIGLLAMALKDIGVEAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLAAGKVVIVAGFQGISSEGDISTLG
RGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRLRVL
SSLQDGGNGTLITFEEDDNMERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGSEGTTDFSF
TVPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEGINIQMISTSEIKVSVLIDEK
YMELATRVLHKAFNLG
>Mature_335_residues
STGEQVTIGLLAMALKDIGVEAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLAAGKVVIVAGFQGISSEGDISTLGR
GGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRLRVLS
SLQDGGNGTLITFEEDDNMERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGSEGTTDFSFT
VPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEGINIQMISTSEIKVSVLIDEKY
MELATRVLHKAFNLG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=353, Percent_Identity=31.4447592067989, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790455, Length=169, Percent_Identity=38.4615384615385, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790376, Length=104, Percent_Identity=34.6153846153846, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320893, Length=363, Percent_Identity=29.2011019283747, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 35977; Mature: 35846

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGEQVTIGLLAMALKDIGVEAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLAAGK
CCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCC
VVIVAGFQGISSEGDISTLGRGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEA
EEEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCH
RRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRLRVLSSLQDGGNGTLITFEEDDNM
HHCCCCCHHHHHHHHHHCHHHEEEEEEEECCCEEHHHEEHHHHCCCCCEEEEEEECCCCC
ERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGSEGTTDFSF
CHHEEEEEEEECCCCEEEEECCCCCCCHHHHEEHHHHCCCCEEEEEEEECCCCCCCCEEE
TVPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEG
ECCCCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCC
INIQMISTSEIKVSVLIDEKYMELATRVLHKAFNLG
CEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STGEQVTIGLLAMALKDIGVEAKSYTGWQVALKTDTAHTKARIESIDDEKMRADLAAGK
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCC
VVIVAGFQGISSEGDISTLGRGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEA
EEEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCH
RRMDTVTFEEMIELASLGSKVLQIRSVEFAGKYKVRLRVLSSLQDGGNGTLITFEEDDNM
HHCCCCCHHHHHHHHHHCHHHEEEEEEEECCCEEHHHEEHHHHCCCCCEEEEEEECCCCC
ERAAVTGIAFDKNQARINVRGVPDKPGVAYQILGAVADANIEVDMIIQNVGSEGTTDFSF
CHHEEEEEEEECCCCEEEEECCCCCCCHHHHEEHHHHCCCCEEEEEEEECCCCCCCCEEE
TVPRGDYKQTLEILSERQDSIGAASIDGDDTVCKVSAVGLGMRSHVGVAAKIFRTLAEEG
ECCCCCHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCC
INIQMISTSEIKVSVLIDEKYMELATRVLHKAFNLG
CEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]