| Definition | Neisseria meningitidis 053442, complete genome. |
|---|---|
| Accession | NC_010120 |
| Length | 2,153,416 |
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The map label for this gene is metE [H]
Identifier: 161869856
GI number: 161869856
Start: 887635
End: 889911
Strand: Direct
Name: metE [H]
Synonym: NMCC_0887
Alternate gene names: 161869856
Gene position: 887635-889911 (Clockwise)
Preceding gene: 161869855
Following gene: 161869857
Centisome position: 41.22
GC content: 52.7
Gene sequence:
>2277_bases ATGACAACATTACATTTTTCAGGCTTCCCGCGTGTCGGTGCCTTCCGCGAATTGAAATTTGCCCAAGAAAAATACTGGCG CAAAGAAATCAGCGAGCAAGAATTGCTGGCTGTTGCCAAAGACTTGCGCGAGAAAAACTGGAAACACCAAGCCGCTGCCA ACGCCGATTACGTTGCCGTAGGCGATTTCACTTTCTACGATCACATCCTCGACCTGCAAGTCGCTACCGGCGCGATTCCC GCCCGCTTCGGCTTCGACAGCCAAAACCTGTCTTTGGAACAATTCTTCCAACTGGCGCGCGGCAACAAAGACCAATTCGC TATCGAAATGACCAAATGGTTCGACACCAACTATCACTACTTGGTGCCTGAATTCCACGCCGATACCGAATTCAAAGCCA ACGCCAAACACTACGTTCAACAACTGCAAGAAGCCCAAGCTTTGGGCTTGAAAGCCAAACCGACCGTTGTTGGTCCGCTG ACTTTCCTGTGGGTAGGTAAAGAAAAAGGTGCGGTTGAATTCGACCGTCTGAGCCTGTTGCCTAAACTGTTGCCTGTTTA CGTTGAAATCCTGACTGCGTTGGTTGAAGCCGGTGCCGAGTGGATTCAAATCGACGAGCCTGCTTTGACTGTCGATCTGC CTAAAGAATGGGTAGAAGCATACAAAGACGTTTACGCTACTTTGAGCAAAGTAAGTGCCAAAATCCTGTTGGGCACTTAC TTCGGTTCTGTTGCCGAACACGCCGCATTGCTGAAAGCCCTGCCCGTTGACGGCCTGCACATCGACTTGGTACGCGCTCC CGAGCAACCGGACGCGTTCGCCGACTACGACAAAGTCCTGTCTGTCGGCGTGATTGACGGCCGCAACATTTGGCGCGCCA ACCTGAACAAAGTTTTGGAAACTGTTGAGCCTCTGCAAGCCAAACTGGGCGAGCGTTTGTGGATTTCCAGCTCTTGCTCG CTGTTGCACACTCCGTTTGACTTGTCAGTTGAAGAAAAACTGAAAGCCAACAAACCCGACCTGTACTCTTGGTTGGCATT TACCCTGCAAAAAACCCAAGAATTGCGCGTTCTGAAAGCCGCATTGAACGAAGGTCGTGATTCTGTTGCCGAAGAACTCG CCGCCAGCCAAGCTGCCGCTGATTCACGCGCCAACAGCAGCGAAATCCACCGCGCGGACGTTGCCAAACGCCTGGCCGAT TTGCCTGCCAACGCAGACCAACGCAAATCACCGTTTGTCAACCGTATCAAAGCGCAACAAGCATGGTTGAACCTGCCTCT GCTGCCGACGACCAACATCGGTTCTTTCCCGCAAACTACCGAAATTCGTCAAGCACGCGCCGCCTTCAAAAAAGGCGAAC TGTCTGCCGCCGATTACGAAGCCGCGATGAAAAAAGAAATCGCCTTGGTGGTTGAAGAGCAAGAAAAACTGGACTTGGAC GTACTGGTACACGGCGAAGCCGAGCGTAACGACATGGTCGAATACTTCGGCGAACTGTTGAGCGGTTTTGCATTCACCCA ATACGGCTGGGTACAAAGCTACGGCTCACGCTGCGTGAAACCACCGATTATCTTCGGTGACGTAAGCCGTCCTGAAGCCA TGACTGTCGCTTGGTCTACTTACGCTCAAAGCCTGACCAAACGCCCGATGAAAGGTATGTTGACCGGCCCTGTAACCATT CTGCAATGGTCTTTCGTCCGCAACGATATTCCCCGCGCTACCGTGTGCAAACAAATCGCACTGGCTCTGAACGACGAAGT ATTGGATCTGGAAAAAGCAGGCATCAAAGTCATCCAAATCGACGAACCTGCCATCCGCGAAGGCCTGCCTTTGAAACGTG CCGATTGGGATGCCTACCTGAACTGGGCCGGCGAATCTTTCCGCCTGTCCTCTGCCGGTTGTGAAGACAGCACTCAGATC CACACCCATATGTGCTACTCCGAGTTCAACGACATCCTGCCGGCCATCGCAGCTATGGATGCCGACGTGATTACTATCGA AACTTCACGTTCCGATATGGAACTCCTGACCGCGTTCGGCAAGTTCAAATACCCGAACGACATCGGCCCGGGCGTTTACG ACATCCACAGCCCGCGCGTACCGACTGAAGCCGAAGTGGAACACCTGTTGCGTAAAGCCATCGAAGTCGTACCGGTTGAG CGTCTGTGGGTGAATCCTGACTGCGGCCTGAAAACACGCGGCTGGAAAGAAACTCTGGAACAACTCCAAGTGATGATGAA CGTAACCCGCAAACTGCGTGCCGAACTGGCGAAATAA
Upstream 100 bases:
>100_bases TCTGAAAAGCAAAACGCCGCCCCATCTAAGCCATTCTGATTTACAATACCGGCCGATTCGGATCGAACCGGTCCTTACAA AATCCAACTGGAGAGTTTAT
Downstream 100 bases:
>100_bases GCCGGAACCGTATGAACAAATGCCGTCTGAAAGCCCTTCAGACGGCATTTTGCCCTGAGTTGCGGCGCAAGGGTGCAGTT GCCGGGAAATTTTCTCATTG
Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
Products: NA
Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]
Number of amino acids: Translated: 758; Mature: 757
Protein sequence:
>758_residues MTTLHFSGFPRVGAFRELKFAQEKYWRKEISEQELLAVAKDLREKNWKHQAAANADYVAVGDFTFYDHILDLQVATGAIP ARFGFDSQNLSLEQFFQLARGNKDQFAIEMTKWFDTNYHYLVPEFHADTEFKANAKHYVQQLQEAQALGLKAKPTVVGPL TFLWVGKEKGAVEFDRLSLLPKLLPVYVEILTALVEAGAEWIQIDEPALTVDLPKEWVEAYKDVYATLSKVSAKILLGTY FGSVAEHAALLKALPVDGLHIDLVRAPEQPDAFADYDKVLSVGVIDGRNIWRANLNKVLETVEPLQAKLGERLWISSSCS LLHTPFDLSVEEKLKANKPDLYSWLAFTLQKTQELRVLKAALNEGRDSVAEELAASQAAADSRANSSEIHRADVAKRLAD LPANADQRKSPFVNRIKAQQAWLNLPLLPTTNIGSFPQTTEIRQARAAFKKGELSAADYEAAMKKEIALVVEEQEKLDLD VLVHGEAERNDMVEYFGELLSGFAFTQYGWVQSYGSRCVKPPIIFGDVSRPEAMTVAWSTYAQSLTKRPMKGMLTGPVTI LQWSFVRNDIPRATVCKQIALALNDEVLDLEKAGIKVIQIDEPAIREGLPLKRADWDAYLNWAGESFRLSSAGCEDSTQI HTHMCYSEFNDILPAIAAMDADVITIETSRSDMELLTAFGKFKYPNDIGPGVYDIHSPRVPTEAEVEHLLRKAIEVVPVE RLWVNPDCGLKTRGWKETLEQLQVMMNVTRKLRAELAK
Sequences:
>Translated_758_residues MTTLHFSGFPRVGAFRELKFAQEKYWRKEISEQELLAVAKDLREKNWKHQAAANADYVAVGDFTFYDHILDLQVATGAIP ARFGFDSQNLSLEQFFQLARGNKDQFAIEMTKWFDTNYHYLVPEFHADTEFKANAKHYVQQLQEAQALGLKAKPTVVGPL TFLWVGKEKGAVEFDRLSLLPKLLPVYVEILTALVEAGAEWIQIDEPALTVDLPKEWVEAYKDVYATLSKVSAKILLGTY FGSVAEHAALLKALPVDGLHIDLVRAPEQPDAFADYDKVLSVGVIDGRNIWRANLNKVLETVEPLQAKLGERLWISSSCS LLHTPFDLSVEEKLKANKPDLYSWLAFTLQKTQELRVLKAALNEGRDSVAEELAASQAAADSRANSSEIHRADVAKRLAD LPANADQRKSPFVNRIKAQQAWLNLPLLPTTNIGSFPQTTEIRQARAAFKKGELSAADYEAAMKKEIALVVEEQEKLDLD VLVHGEAERNDMVEYFGELLSGFAFTQYGWVQSYGSRCVKPPIIFGDVSRPEAMTVAWSTYAQSLTKRPMKGMLTGPVTI LQWSFVRNDIPRATVCKQIALALNDEVLDLEKAGIKVIQIDEPAIREGLPLKRADWDAYLNWAGESFRLSSAGCEDSTQI HTHMCYSEFNDILPAIAAMDADVITIETSRSDMELLTAFGKFKYPNDIGPGVYDIHSPRVPTEAEVEHLLRKAIEVVPVE RLWVNPDCGLKTRGWKETLEQLQVMMNVTRKLRAELAK >Mature_757_residues TTLHFSGFPRVGAFRELKFAQEKYWRKEISEQELLAVAKDLREKNWKHQAAANADYVAVGDFTFYDHILDLQVATGAIPA RFGFDSQNLSLEQFFQLARGNKDQFAIEMTKWFDTNYHYLVPEFHADTEFKANAKHYVQQLQEAQALGLKAKPTVVGPLT FLWVGKEKGAVEFDRLSLLPKLLPVYVEILTALVEAGAEWIQIDEPALTVDLPKEWVEAYKDVYATLSKVSAKILLGTYF GSVAEHAALLKALPVDGLHIDLVRAPEQPDAFADYDKVLSVGVIDGRNIWRANLNKVLETVEPLQAKLGERLWISSSCSL LHTPFDLSVEEKLKANKPDLYSWLAFTLQKTQELRVLKAALNEGRDSVAEELAASQAAADSRANSSEIHRADVAKRLADL PANADQRKSPFVNRIKAQQAWLNLPLLPTTNIGSFPQTTEIRQARAAFKKGELSAADYEAAMKKEIALVVEEQEKLDLDV LVHGEAERNDMVEYFGELLSGFAFTQYGWVQSYGSRCVKPPIIFGDVSRPEAMTVAWSTYAQSLTKRPMKGMLTGPVTIL QWSFVRNDIPRATVCKQIALALNDEVLDLEKAGIKVIQIDEPAIREGLPLKRADWDAYLNWAGESFRLSSAGCEDSTQIH THMCYSEFNDILPAIAAMDADVITIETSRSDMELLTAFGKFKYPNDIGPGVYDIHSPRVPTEAEVEHLLRKAIEVVPVER LWVNPDCGLKTRGWKETLEQLQVMMNVTRKLRAELAK
Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]
COG id: COG0620
COG function: function code E; Methionine synthase II (cobalamin-independent)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]
Homologues:
Organism=Escherichia coli, GI2367304, Length=761, Percent_Identity=54.796320630749, Blast_Score=821, Evalue=0.0, Organism=Saccharomyces cerevisiae, GI6320936, Length=768, Percent_Identity=47.5260416666667, Blast_Score=671, Evalue=0.0,
Paralogues:
None
Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013215 - InterPro: IPR006276 - InterPro: IPR002629 [H]
Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]
EC number: =2.1.1.14 [H]
Molecular weight: Translated: 85086; Mature: 84955
Theoretical pI: Translated: 5.33; Mature: 5.33
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTTLHFSGFPRVGAFRELKFAQEKYWRKEISEQELLAVAKDLREKNWKHQAAANADYVAV CCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCEEEE GDFTFYDHILDLQVATGAIPARFGFDSQNLSLEQFFQLARGNKDQFAIEMTKWFDTNYHY CCCHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHCCCCCEE LVPEFHADTEFKANAKHYVQQLQEAQALGLKAKPTVVGPLTFLWVGKEKGAVEFDRLSLL ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCCCCCCHHHHHHH PKLLPVYVEILTALVEAGAEWIQIDEPALTVDLPKEWVEAYKDVYATLSKVSAKILLGTY HHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH FGSVAEHAALLKALPVDGLHIDLVRAPEQPDAFADYDKVLSVGVIDGRNIWRANLNKVLE HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHH TVEPLQAKLGERLWISSSCSLLHTPFDLSVEEKLKANKPDLYSWLAFTLQKTQELRVLKA HHHHHHHHHCCEEEECCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH ALNEGRDSVAEELAASQAAADSRANSSEIHRADVAKRLADLPANADQRKSPFVNRIKAQQ HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH AWLNLPLLPTTNIGSFPQTTEIRQARAAFKKGELSAADYEAAMKKEIALVVEEQEKLDLD HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEE VLVHGEAERNDMVEYFGELLSGFAFTQYGWVQSYGSRCVKPPIIFGDVSRPEAMTVAWST EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEHHHH YAQSLTKRPMKGMLTGPVTILQWSFVRNDIPRATVCKQIALALNDEVLDLEKAGIKVIQI HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEEEE DEPAIREGLPLKRADWDAYLNWAGESFRLSSAGCEDSTQIHTHMCYSEFNDILPAIAAMD CCHHHHCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC ADVITIETSRSDMELLTAFGKFKYPNDIGPGVYDIHSPRVPTEAEVEHLLRKAIEVVPVE CCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCHH RLWVNPDCGLKTRGWKETLEQLQVMMNVTRKLRAELAK HEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure TTLHFSGFPRVGAFRELKFAQEKYWRKEISEQELLAVAKDLREKNWKHQAAANADYVAV CEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCEEEE GDFTFYDHILDLQVATGAIPARFGFDSQNLSLEQFFQLARGNKDQFAIEMTKWFDTNYHY CCCHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHCCCCCEE LVPEFHADTEFKANAKHYVQQLQEAQALGLKAKPTVVGPLTFLWVGKEKGAVEFDRLSLL ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCCCCCCHHHHHHH PKLLPVYVEILTALVEAGAEWIQIDEPALTVDLPKEWVEAYKDVYATLSKVSAKILLGTY HHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH FGSVAEHAALLKALPVDGLHIDLVRAPEQPDAFADYDKVLSVGVIDGRNIWRANLNKVLE HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHH TVEPLQAKLGERLWISSSCSLLHTPFDLSVEEKLKANKPDLYSWLAFTLQKTQELRVLKA HHHHHHHHHCCEEEECCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH ALNEGRDSVAEELAASQAAADSRANSSEIHRADVAKRLADLPANADQRKSPFVNRIKAQQ HHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH AWLNLPLLPTTNIGSFPQTTEIRQARAAFKKGELSAADYEAAMKKEIALVVEEQEKLDLD HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEE VLVHGEAERNDMVEYFGELLSGFAFTQYGWVQSYGSRCVKPPIIFGDVSRPEAMTVAWST EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEHHHH YAQSLTKRPMKGMLTGPVTILQWSFVRNDIPRATVCKQIALALNDEVLDLEKAGIKVIQI HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEEEE DEPAIREGLPLKRADWDAYLNWAGESFRLSSAGCEDSTQIHTHMCYSEFNDILPAIAAMD CCHHHHCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC ADVITIETSRSDMELLTAFGKFKYPNDIGPGVYDIHSPRVPTEAEVEHLLRKAIEVVPVE CCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCHH RLWVNPDCGLKTRGWKETLEQLQVMMNVTRKLRAELAK HEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA