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The map label for this gene is folE2

Identifier: 161869746

GI number: 161869746

Start: 773451

End: 774347

Strand: Direct

Name: folE2

Synonym: NMCC_0766

Alternate gene names: 161869746

Gene position: 773451-774347 (Clockwise)

Preceding gene: 161869745

Following gene: 161869748

Centisome position: 35.92

GC content: 50.39

Gene sequence:

>897_bases
ATGCAGCTGCTAAAAGCGAGTGATATAATCTCGCATTTGCAGATTGACGGTATATTCCCCGGCGGAAACGCCATACCATG
CACACATCTCAACAATTACATGAATATTAAGGAAAAACAACTCATGAACACTATTGCAGACGTGCAATCCAGCCGAGATT
TGCGCAATCTGCCGATCAATCAGGTCGGTATCAAAGACCTGCGCTTTCCGATTACCCTGCAAACTGCAGAAGGCATCCAG
TCCACCATTGCCCGTCTGACCATGACGGTTTACCTGCCCGCCGAGCAGAAGGGTACGCATATGTCGCGCTTTGTCGCATT
GATGGAGCAATATTCTGAAGCCTTGGATTTCGCACAATTGCATAGGCTGACTGCCGAAATGGTCGCGCTTTTGGATTCCC
GCGCCGGTAAAATCAGCGTTTCTTTCCCATTTTTCCGCAAGAAAACCGCCCCGGTTTCCGGTATTCAGTCTTTACTGGAT
TATGATGTCTGCCTCACGGGCGAAATGAAAGACGGTGCATACGGCCACAGTATGAAGGTCATGATTCCCGTAACCTCGCT
TTGCCCGTGTTCCAAAGAAATTTCCCAATATGGCGCGCACAACCAGCGTTCGCACGTTACCGTCAGCCTGACTGCCGATG
CCGAAGTCGGTATCGAGGAAGTCATCGATTATGTGGAGGCGCAGGCGAGCTGCCAACTCTACGGCCTGCTCAAACGCCCC
GATGAAAAATACGTTACCGAAAAGGCCTACGAAAACCCGAAATTCGTGGAAGATATGGTGCGCGATGTCGCTACTTCGCT
GATCGCCGACAAACGCATCAAGAGTTTCGTTGTCGAGAGCGAGAATTTCGAGTCTATCCACAACCATTCGGCTTATGCCT
ATATCGCCTACCCGTAG

Upstream 100 bases:

>100_bases
CTGGAATGAATGGCTTTCGTGGCGAATTTCATTTGGTCTCTGCCTATGTAGATGTGAATAATCGAAGATTTTATCACTAT
CTGAAAAATAGAAACAATCA

Downstream 100 bases:

>100_bases
GCGCGTTTGCAATGATGCCCAAATGCCGTCTGAAAGGCATTGGGGCGTTATTCCCGAGTCTGCCGCCGCTTTGTTTTCCC
AGCCGTAGCAGAGATGGGTA

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPINQVGIKDLRFPITLQTAEGIQ
STIARLTMTVYLPAEQKGTHMSRFVALMEQYSEALDFAQLHRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIQSLLD
YDVCLTGEMKDGAYGHSMKVMIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRP
DEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP

Sequences:

>Translated_298_residues
MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPINQVGIKDLRFPITLQTAEGIQ
STIARLTMTVYLPAEQKGTHMSRFVALMEQYSEALDFAQLHRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIQSLLD
YDVCLTGEMKDGAYGHSMKVMIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRP
DEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP
>Mature_298_residues
MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPINQVGIKDLRFPITLQTAEGIQ
STIARLTMTVYLPAEQKGTHMSRFVALMEQYSEALDFAQLHRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIQSLLD
YDVCLTGEMKDGAYGHSMKVMIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRP
DEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_NEIM0 (A9M3N5)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001598914.1
- ProteinModelPortal:   A9M3N5
- SMR:   A9M3N5
- EnsemblBacteria:   EBNEIT00000012850
- GeneID:   5795111
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_0766
- GeneTree:   EBGT00050000020556
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   NMEN374833:NMCC_0766-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 33292; Mature: 33292

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPIN
CCCCHHHHHHHHHEEEEECCCCCCCCHHHCCCHHCHHHHHHHHHHHHHHHCCCHHCCCCC
QVGIKDLRFPITLQTAEGIQSTIARLTMTVYLPAEQKGTHMSRFVALMEQYSEALDFAQL
CCCHHHCCCEEEEECHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
HRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIQSLLDYDVCLTGEMKDGAYGHSMKV
HHHHHHHHHHHHCCCCEEEEECCHHHCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEE
MIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRP
EEECCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHEEHHHCCC
DEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECC
>Mature Secondary Structure
MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPIN
CCCCHHHHHHHHHEEEEECCCCCCCCHHHCCCHHCHHHHHHHHHHHHHHHCCCHHCCCCC
QVGIKDLRFPITLQTAEGIQSTIARLTMTVYLPAEQKGTHMSRFVALMEQYSEALDFAQL
CCCHHHCCCEEEEECHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
HRLTAEMVALLDSRAGKISVSFPFFRKKTAPVSGIQSLLDYDVCLTGEMKDGAYGHSMKV
HHHHHHHHHHHHCCCCEEEEECCHHHCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEE
MIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRP
EEECCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHEEHHHCCC
DEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA