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The map label for this gene is hemB [H]

Identifier: 161869745

GI number: 161869745

Start: 771322

End: 772161

Strand: Direct

Name: hemB [H]

Synonym: NMCC_0765

Alternate gene names: 161869745

Gene position: 771322-772161 (Clockwise)

Preceding gene: 161869744

Following gene: 161869746

Centisome position: 35.82

GC content: 56.31

Gene sequence:

>840_bases
ATGCCGGGTGTGAAGCGTCAAAGTTTGGACAGGCTGCTGTTTACGGCGGAAGAGGCGGTAAAGCTCGGTATTCCGATGTT
GGCACTGTTCCCCGTGGTTACGGCAAACAAAACCGAGCGTGCGCAGGAGGCGTACAATCCCGAAGGACTCGTGCCGTCAA
CTGTCCGCGCCTTGCGCGAGAGGTTTCCCGAACTGGGCATTATGACGGATGTCGCGCTCGATCCTTATACGGTTCACGGT
CAGGACGGGCTGACGGACGAAAACGGTTATGTGATGAACGATGAAACCGTAGAGGTTTTGGTCAAGCAGGCTTTGTGCCA
CGCTGAAGCGGGCGCGCAGGTGGTTGCCCCTTCCGATATGATGGACGGGCGTATCGGTGCGATTCGCGAGGCGTTGGAGG
ATGCCGGGCATATCCATACGCGGATTATGGCGTATTCCGCCAAATATGCTTCTGCATTTTACGGCCCTTTCCGTGATGCG
GTAGGCAGTTCGGGCAATTTGGGCAAGGCAGATAAAAAGACCTATCAGATGGATCCCGCAAATACCGATGAGGCGCTGCA
TGAGGTGGCGTTGGACATTCAGGAAGGTGCGGATATGGTGATGGTCAAGCCCGGTTTGCCGTATTTGGACGTTGTCCGAC
GCGTGAAGGACGAGTTCGGTGTGCCGACTTATGCCTATCAGGTTTCGGGCGAATATGCGATGCTGCAGGCGGCGGTTGCC
AACGGCTGGCTGGACGGCGATAAGGTGGTCTTGGAAAGCCTGCTGGCATTCAAACGTGCGGGCGCGGACGGGATTTTGAC
CTATTATGCCATTGAGGCGGCAAAGATGCTGAAGCGTTGA

Upstream 100 bases:

>100_bases
TTCACGCCGCCTGATGCGCGAACACACGCTGACCGCCGATGATTTGATTTATCCGGTGTTCGTATTGGAGGGGTCGGCGC
GCGAGGAGGATGTGCCTTCT

Downstream 100 bases:

>100_bases
TTTTCGGTCGGTTTGATTGAAATGCCGTCTGAAACCATGGTTTCAGACGGCATTTTTCGTGGATTATACAGTCGTATCCA
GTGCGGCGGAAATATCATTC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MPGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRERFPELGIMTDVALDPYTVHG
QDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMMDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDA
VGSSGNLGKADKKTYQMDPANTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVA
NGWLDGDKVVLESLLAFKRAGADGILTYYAIEAAKMLKR

Sequences:

>Translated_279_residues
MPGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRERFPELGIMTDVALDPYTVHG
QDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMMDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDA
VGSSGNLGKADKKTYQMDPANTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVA
NGWLDGDKVVLESLLAFKRAGADGILTYYAIEAAKMLKR
>Mature_278_residues
PGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRERFPELGIMTDVALDPYTVHGQ
DGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMMDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAV
GSSGNLGKADKKTYQMDPANTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVAN
GWLDGDKVVLESLLAFKRAGADGILTYYAIEAAKMLKR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=281, Percent_Identity=46.2633451957295, Blast_Score=225, Evalue=4e-59,
Organism=Escherichia coli, GI87081728, Length=275, Percent_Identity=45.8181818181818, Blast_Score=214, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6321398, Length=276, Percent_Identity=39.8550724637681, Blast_Score=181, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21358291, Length=271, Percent_Identity=44.6494464944649, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 30377; Mature: 30246

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRE
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHH
RFPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDM
HCCCCCCEEECCCCCEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEECCCHH
MDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCC
NTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVA
CHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
NGWLDGDKVVLESLLAFKRAGADGILTYYAIEAAKMLKR
HCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRE
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHH
RFPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDM
HCCCCCCEEECCCCCEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEECCCHH
MDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCC
NTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVA
CHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
NGWLDGDKVVLESLLAFKRAGADGILTYYAIEAAKMLKR
HCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]