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The map label for this gene is hemE [H]

Identifier: 161869724

GI number: 161869724

Start: 746727

End: 747791

Strand: Direct

Name: hemE [H]

Synonym: NMCC_0744

Alternate gene names: 161869724

Gene position: 746727-747791 (Clockwise)

Preceding gene: 161869723

Following gene: 161869728

Centisome position: 34.68

GC content: 56.43

Gene sequence:

>1065_bases
ATGACTCTTTTAAAAAACGATACCTTCCTCCGCGCCCTGCTTAAACAGCCCGTCGAATACACGCCGATTTGGATGATGCG
TCAGGCGGGGCGTTATCTGCCCGAATACAAAGCCACACGCGCGAAAGCGGGCAGCTTCCTCGATTTGTGCAAAAACACCG
AATTGGCGACCGAAGTTACCATCCAACCTTTGGAACGTTTCGATTTGGACGCGGCGATTTTGTTTTCCGACATCCTGACC
GTCCCCGACGCAATGGGCTTGGGACTGTATTTTGCCGAAGGCGAAGGCCCGAAATTCAAACGCGCCCTGCAACACGAGGA
CGACATTGCCAAATTGCACGTCCCCGATATGGAAAAACTGCAATACGTTTTCGACGCGGTAACTTCCATCCGTAAAGCAT
TGGACGGCCGCGTACCGCTTATCGGCTTCTCCGGCAGTCCGTTCACGCTCGCCTGTTACATGGTCGAAGGCGGCAGCAGC
AAAGAATTCCGCACCATCAAAACCATGATGTACTCGCGCCCCGATTTGCTGCACAAAATCCTCGATACCAACGCCCAAGC
CGTTACCGCCTACCTCAACGCCCAAATCGACGCGGGAGCGCAGGCTGTGCAGATTTTCGACACTTGGGGCGGCGTCTTGA
GCGATGCGGCGTTTAAAGAATTCAGCCTCAAATACATCCGCCAAATTGTTGCCGGACTGAAACGCGAAAGCGAAGGCAGG
CGCGTGCCTGTCATCGTGTTTGCCAAAGGCGGCGGGCTGTGGCTGGAAAGCATGGCAGAAATCGGCGCAGACGCATTGGG
CTTGGACTGGACGTGCAACATCGGCGAAGCACGCCGCCGCGTCGGCAAGCAAGTCGCCCTGCAAGGCAACTTCGACCCGT
TTGCTCTCTTTGGCACACCCGAATCCATCCGCACCGAAGTCGCGCGCATCCTAGCCGACTACGGACACGGCAGCGGCCAC
GTCTTCAATCTCGGACACGGCATCAACCAACACGCCGACCCCGAACACGCCAAAATCTTAGTCGATACCGTACACGAGTT
GTCGCGGCAGTATCACGGCGGGTAA

Upstream 100 bases:

>100_bases
ACCGACCTTCCGCCGAAACCCATTGAAACCTTCAGACGGCATCGTTGAAATGCCGTCTGAAAACCATTTCACTTGACAAA
CAGACTGACAGAAAACCCGT

Downstream 100 bases:

>100_bases
GCCGGCAGGAAACTGCCCGATATGCCGTCTGAAGAATCGGAAGTTTTCAGACGGCATATGCTTCATTTTGCACTTTGGTA
CACCAAGCCATTGTGTGGTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTLLKNDTFLRALLKQPVEYTPIWMMRQAGRYLPEYKATRAKAGSFLDLCKNTELATEVTIQPLERFDLDAAILFSDILT
VPDAMGLGLYFAEGEGPKFKRALQHEDDIAKLHVPDMEKLQYVFDAVTSIRKALDGRVPLIGFSGSPFTLACYMVEGGSS
KEFRTIKTMMYSRPDLLHKILDTNAQAVTAYLNAQIDAGAQAVQIFDTWGGVLSDAAFKEFSLKYIRQIVAGLKRESEGR
RVPVIVFAKGGGLWLESMAEIGADALGLDWTCNIGEARRRVGKQVALQGNFDPFALFGTPESIRTEVARILADYGHGSGH
VFNLGHGINQHADPEHAKILVDTVHELSRQYHGG

Sequences:

>Translated_354_residues
MTLLKNDTFLRALLKQPVEYTPIWMMRQAGRYLPEYKATRAKAGSFLDLCKNTELATEVTIQPLERFDLDAAILFSDILT
VPDAMGLGLYFAEGEGPKFKRALQHEDDIAKLHVPDMEKLQYVFDAVTSIRKALDGRVPLIGFSGSPFTLACYMVEGGSS
KEFRTIKTMMYSRPDLLHKILDTNAQAVTAYLNAQIDAGAQAVQIFDTWGGVLSDAAFKEFSLKYIRQIVAGLKRESEGR
RVPVIVFAKGGGLWLESMAEIGADALGLDWTCNIGEARRRVGKQVALQGNFDPFALFGTPESIRTEVARILADYGHGSGH
VFNLGHGINQHADPEHAKILVDTVHELSRQYHGG
>Mature_353_residues
TLLKNDTFLRALLKQPVEYTPIWMMRQAGRYLPEYKATRAKAGSFLDLCKNTELATEVTIQPLERFDLDAAILFSDILTV
PDAMGLGLYFAEGEGPKFKRALQHEDDIAKLHVPDMEKLQYVFDAVTSIRKALDGRVPLIGFSGSPFTLACYMVEGGSSK
EFRTIKTMMYSRPDLLHKILDTNAQAVTAYLNAQIDAGAQAVQIFDTWGGVLSDAAFKEFSLKYIRQIVAGLKRESEGRR
VPVIVFAKGGGLWLESMAEIGADALGLDWTCNIGEARRRVGKQVALQGNFDPFALFGTPESIRTEVARILADYGHGSGHV
FNLGHGINQHADPEHAKILVDTVHELSRQYHGG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=47.2934472934473, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=67.1388101983003, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=41.0764872521246, Blast_Score=273, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19921920, Length=349, Percent_Identity=40.974212034384, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI221330099, Length=349, Percent_Identity=40.974212034384, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39194; Mature: 39063

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLKNDTFLRALLKQPVEYTPIWMMRQAGRYLPEYKATRAKAGSFLDLCKNTELATEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHCCCCHHHHHH
IQPLERFDLDAAILFSDILTVPDAMGLGLYFAEGEGPKFKRALQHEDDIAKLHVPDMEKL
HHHHHHHCCHHHHHHHHHHHCCCHHCCCEEEECCCCHHHHHHHCCCCCCEEECCCCHHHH
QYVFDAVTSIRKALDGRVPLIGFSGSPFTLACYMVEGGSSKEFRTIKTMMYSRPDLLHKI
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
LDTNAQAVTAYLNAQIDAGAQAVQIFDTWGGVLSDAAFKEFSLKYIRQIVAGLKRESEGR
HCCCHHHEEHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RVPVIVFAKGGGLWLESMAEIGADALGLDWTCNIGEARRRVGKQVALQGNFDPFALFGTP
EEEEEEEECCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCCEEEECCC
ESIRTEVARILADYGHGSGHVFNLGHGINQHADPEHAKILVDTVHELSRQYHGG
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLKNDTFLRALLKQPVEYTPIWMMRQAGRYLPEYKATRAKAGSFLDLCKNTELATEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHCCCCHHHHHH
IQPLERFDLDAAILFSDILTVPDAMGLGLYFAEGEGPKFKRALQHEDDIAKLHVPDMEKL
HHHHHHHCCHHHHHHHHHHHCCCHHCCCEEEECCCCHHHHHHHCCCCCCEEECCCCHHHH
QYVFDAVTSIRKALDGRVPLIGFSGSPFTLACYMVEGGSSKEFRTIKTMMYSRPDLLHKI
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHH
LDTNAQAVTAYLNAQIDAGAQAVQIFDTWGGVLSDAAFKEFSLKYIRQIVAGLKRESEGR
HCCCHHHEEHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RVPVIVFAKGGGLWLESMAEIGADALGLDWTCNIGEARRRVGKQVALQGNFDPFALFGTP
EEEEEEEECCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCCEEEECCC
ESIRTEVARILADYGHGSGHVFNLGHGINQHADPEHAKILVDTVHELSRQYHGG
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA