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The map label for this gene is thrS [H]

Identifier: 161869662

GI number: 161869662

Start: 692844

End: 694757

Strand: Direct

Name: thrS [H]

Synonym: NMCC_0680

Alternate gene names: 161869662

Gene position: 692844-694757 (Clockwise)

Preceding gene: 161869658

Following gene: 161869663

Centisome position: 32.17

GC content: 49.16

Gene sequence:

>1914_bases
ATGTTGAATATTACCTTGCCGGACGGCTCAGTCCGCCAATACGAATCCCCCGTTACCGTGGCTCAAATTGCTGCGTCTAT
CGGTGCCGGTTTGGCGAAGGCGGCAGTGGCAGGCAAGGTAAACGGCAAATTGGTCGATGCGTGCGATCCGATTACCGAAG
ATTCAAGCGTCCAAATCATTACTCCGAAAGATCAGGAAGGCATCGAAATCATCCGCCATTCCTGCGCGCATCTTGTCGGG
CATGCCGTCAAGCAACTCTATCCTAATGCAAAAATGGTTATCGGCCCCGTCATTGAAGAGGGCTTTTATTACGACATCGC
CACGGAAAAACCGTTTACACCGGAAGATGTTGCCGCCATTGAAGCGCGTATGAAAGAATTGATTGCCCAAGACTATGATG
TGGTCAAAATCATGACTCCGCGTGCGGAGGCGATTAAAATTTTTCAAGAGCGCGGCGAAGAATACAAACTGCGCCTGATT
GACGATATGCCCGAAGTGGAAGCGATGGGGATGTATCATCACCAGGAATATGTCGATATGTGCCGCGGCCCACACGTTCC
GAATACCCGTTTCCTGAAAAACTTCAAACTGACCAAGTTGGCGGGCGCATACTGGCGCGGCGACAGCAACAATGAAATGC
TGCAACGCATCTACGGTACGGCTTGGGCGACAAAAGACGAGTTGAAAGCCTATATTCAACGTATCGAAGAAGCCGAAAAG
CGCGACCACCGCAAATTGGGCAAACAACTGGATTTGTTCCACTTGCAAGACGAAGCACCGGGTATGGTGTTTTGGCATCC
CAAAGGCTGGGCTTTGTGGCAAGTGATTGAGCAGCATATGCGGAAAGAGCTGAATGCCGCCGGTTATAAAGAGGTCAAAA
CGCCTCAAATCATGGATAAAACCTTTTGGGAAAAATCCGGCCATTGGGACAACTACAAAGACAATATGTTCGTGACCAGT
TCAGAAAAACGCGAATATGCGGTTAAACCGATGAACTGTCCGGGTCATGTTCAAATTTTTAACAACGGTTTGCGTTCGTA
TCGAGATTTGCCGATGCGTTTGGCGGAATTCGGTTCTTGCCACCGCAATGAGCCGAGCGGTGCGCTGCACGGTCTGATGC
GGGTTCGCGGTTTTGTGCAGGATGATGCGCATATTTTCTGTACCGAAGATCAAATCGTCAGCGAGGCTCGTGCGTTCAAT
GAATTGTTGGTTCGCATCTACAAACAGTTCGGTTTCCATGATGTATCCGTCAAGCTTTCTCTTCGCCCTGAAAAACGTGC
AGGTTCAGATGACGTGTGGGATAAGGCAGAGCAGGGTTTGCGCGAGGCATTGACTGCCTGCGGCGTGGAATGGGGCGAAT
TGCCGGGCGAGGGTGCGTTTTACGGGCCTAAAATCGAATATCATGTCAGAGATGCCTTGGGTCGTTCTTGGCAATGCGGT
ACATTACAACTGGATTTCGTCTTGCCGGAACGCTTGGGTGCAGAATATGTAACCGAAAACAACGACCGTGCGCGTCCTGT
AATGTTGCATCGTGCTATTTTGGGTTCTTTGGAGCGATTTATCGGCATTCTGATTGAGAACCATGCAGGCTCTTTCCCGT
TATGGCTGGCTCCGGTTCAATTGGTAATTATGAATATTACCGAAAATCAGGCAGATTATTGTCGGGAAGTGGCTGCCAAA
TTGCAGGCGGCAGGATTCCGCGCCGAGTTGGATTTGCGTAACGAAAAAATCGGTTACAAAATCCGCGACAACAGCCAATA
CCGTTTTCCTTATCAAATCGTTGTCGGCGATAAAGAGAAACAAGAAAACAAAGTTGCGGTACGCCGCAAAGCAGAAGACT
TGGGTTCTTTGGATTTGGATGATTTCATTGCGCAATTGCAGCAAGAAATCACTGATGCCCTCGTCAATCATTAA

Upstream 100 bases:

>100_bases
ACCTTGACATGGTGGGGGTCGTTGGTTCGAATCCAATCGTGCCTACCAAATCCCCATAACGGCATTTATGCCGTTATTTT
TTAATCTTTCGGAGCGTTTG

Downstream 100 bases:

>100_bases
TTTTTATAGGAGTATTCATCATCGCTCAAGAACGCGAAGCACGAATCAACGGCGAAATTACCGCCAAAGAAGTGCGTTTA
ATCAGTGAGTCAGGCGAACA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MLNITLPDGSVRQYESPVTVAQIAASIGAGLAKAAVAGKVNGKLVDACDPITEDSSVQIITPKDQEGIEIIRHSCAHLVG
HAVKQLYPNAKMVIGPVIEEGFYYDIATEKPFTPEDVAAIEARMKELIAQDYDVVKIMTPRAEAIKIFQERGEEYKLRLI
DDMPEVEAMGMYHHQEYVDMCRGPHVPNTRFLKNFKLTKLAGAYWRGDSNNEMLQRIYGTAWATKDELKAYIQRIEEAEK
RDHRKLGKQLDLFHLQDEAPGMVFWHPKGWALWQVIEQHMRKELNAAGYKEVKTPQIMDKTFWEKSGHWDNYKDNMFVTS
SEKREYAVKPMNCPGHVQIFNNGLRSYRDLPMRLAEFGSCHRNEPSGALHGLMRVRGFVQDDAHIFCTEDQIVSEARAFN
ELLVRIYKQFGFHDVSVKLSLRPEKRAGSDDVWDKAEQGLREALTACGVEWGELPGEGAFYGPKIEYHVRDALGRSWQCG
TLQLDFVLPERLGAEYVTENNDRARPVMLHRAILGSLERFIGILIENHAGSFPLWLAPVQLVIMNITENQADYCREVAAK
LQAAGFRAELDLRNEKIGYKIRDNSQYRFPYQIVVGDKEKQENKVAVRRKAEDLGSLDLDDFIAQLQQEITDALVNH

Sequences:

>Translated_637_residues
MLNITLPDGSVRQYESPVTVAQIAASIGAGLAKAAVAGKVNGKLVDACDPITEDSSVQIITPKDQEGIEIIRHSCAHLVG
HAVKQLYPNAKMVIGPVIEEGFYYDIATEKPFTPEDVAAIEARMKELIAQDYDVVKIMTPRAEAIKIFQERGEEYKLRLI
DDMPEVEAMGMYHHQEYVDMCRGPHVPNTRFLKNFKLTKLAGAYWRGDSNNEMLQRIYGTAWATKDELKAYIQRIEEAEK
RDHRKLGKQLDLFHLQDEAPGMVFWHPKGWALWQVIEQHMRKELNAAGYKEVKTPQIMDKTFWEKSGHWDNYKDNMFVTS
SEKREYAVKPMNCPGHVQIFNNGLRSYRDLPMRLAEFGSCHRNEPSGALHGLMRVRGFVQDDAHIFCTEDQIVSEARAFN
ELLVRIYKQFGFHDVSVKLSLRPEKRAGSDDVWDKAEQGLREALTACGVEWGELPGEGAFYGPKIEYHVRDALGRSWQCG
TLQLDFVLPERLGAEYVTENNDRARPVMLHRAILGSLERFIGILIENHAGSFPLWLAPVQLVIMNITENQADYCREVAAK
LQAAGFRAELDLRNEKIGYKIRDNSQYRFPYQIVVGDKEKQENKVAVRRKAEDLGSLDLDDFIAQLQQEITDALVNH
>Mature_637_residues
MLNITLPDGSVRQYESPVTVAQIAASIGAGLAKAAVAGKVNGKLVDACDPITEDSSVQIITPKDQEGIEIIRHSCAHLVG
HAVKQLYPNAKMVIGPVIEEGFYYDIATEKPFTPEDVAAIEARMKELIAQDYDVVKIMTPRAEAIKIFQERGEEYKLRLI
DDMPEVEAMGMYHHQEYVDMCRGPHVPNTRFLKNFKLTKLAGAYWRGDSNNEMLQRIYGTAWATKDELKAYIQRIEEAEK
RDHRKLGKQLDLFHLQDEAPGMVFWHPKGWALWQVIEQHMRKELNAAGYKEVKTPQIMDKTFWEKSGHWDNYKDNMFVTS
SEKREYAVKPMNCPGHVQIFNNGLRSYRDLPMRLAEFGSCHRNEPSGALHGLMRVRGFVQDDAHIFCTEDQIVSEARAFN
ELLVRIYKQFGFHDVSVKLSLRPEKRAGSDDVWDKAEQGLREALTACGVEWGELPGEGAFYGPKIEYHVRDALGRSWQCG
TLQLDFVLPERLGAEYVTENNDRARPVMLHRAILGSLERFIGILIENHAGSFPLWLAPVQLVIMNITENQADYCREVAAK
LQAAGFRAELDLRNEKIGYKIRDNSQYRFPYQIVVGDKEKQENKVAVRRKAEDLGSLDLDDFIAQLQQEITDALVNH

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=39.0822784810127, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=614, Percent_Identity=38.4364820846906, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=647, Percent_Identity=36.7851622874807, Blast_Score=414, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=629, Percent_Identity=62.1621621621622, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=157, Percent_Identity=28.6624203821656, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984184, Length=632, Percent_Identity=39.3987341772152, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=632, Percent_Identity=39.3987341772152, Blast_Score=476, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322112, Length=629, Percent_Identity=39.1096979332273, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322654, Length=442, Percent_Identity=38.9140271493213, Blast_Score=304, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24583839, Length=638, Percent_Identity=38.871473354232, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583842, Length=638, Percent_Identity=38.871473354232, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=638, Percent_Identity=38.871473354232, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72581; Mature: 72581

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNITLPDGSVRQYESPVTVAQIAASIGAGLAKAAVAGKVNGKLVDACDPITEDSSVQII
CEEEECCCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEEE
TPKDQEGIEIIRHSCAHLVGHAVKQLYPNAKMVIGPVIEEGFYYDIATEKPFTPEDVAAI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCEEEEECCCCCCCHHHHHHH
EARMKELIAQDYDVVKIMTPRAEAIKIFQERGEEYKLRLIDDMPEVEAMGMYHHQEYVDM
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
CRGPHVPNTRFLKNFKLTKLAGAYWRGDSNNEMLQRIYGTAWATKDELKAYIQRIEEAEK
HCCCCCCCHHHHHCCCHHHHHCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKQLDLFHLQDEAPGMVFWHPKGWALWQVIEQHMRKELNAAGYKEVKTPQIMDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
TFWEKSGHWDNYKDNMFVTSSEKREYAVKPMNCPGHVQIFNNGLRSYRDLPMRLAEFGSC
HHHHCCCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
HRNEPSGALHGLMRVRGFVQDDAHIFCTEDQIVSEARAFNELLVRIYKQFGFHDVSVKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
LRPEKRAGSDDVWDKAEQGLREALTACGVEWGELPGEGAFYGPKIEYHVRDALGRSWQCG
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCC
TLQLDFVLPERLGAEYVTENNDRARPVMLHRAILGSLERFIGILIENHAGSFPLWLAPVQ
CEEEEEECHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVIMNITENQADYCREVAAKLQAAGFRAELDLRNEKIGYKIRDNSQYRFPYQIVVGDKEK
HEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCEECEEEEEECCCCC
QENKVAVRRKAEDLGSLDLDDFIAQLQQEITDALVNH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNITLPDGSVRQYESPVTVAQIAASIGAGLAKAAVAGKVNGKLVDACDPITEDSSVQII
CEEEECCCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEEE
TPKDQEGIEIIRHSCAHLVGHAVKQLYPNAKMVIGPVIEEGFYYDIATEKPFTPEDVAAI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCEEEEECCCCCCCHHHHHHH
EARMKELIAQDYDVVKIMTPRAEAIKIFQERGEEYKLRLIDDMPEVEAMGMYHHQEYVDM
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
CRGPHVPNTRFLKNFKLTKLAGAYWRGDSNNEMLQRIYGTAWATKDELKAYIQRIEEAEK
HCCCCCCCHHHHHCCCHHHHHCHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKQLDLFHLQDEAPGMVFWHPKGWALWQVIEQHMRKELNAAGYKEVKTPQIMDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
TFWEKSGHWDNYKDNMFVTSSEKREYAVKPMNCPGHVQIFNNGLRSYRDLPMRLAEFGSC
HHHHCCCCCCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
HRNEPSGALHGLMRVRGFVQDDAHIFCTEDQIVSEARAFNELLVRIYKQFGFHDVSVKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
LRPEKRAGSDDVWDKAEQGLREALTACGVEWGELPGEGAFYGPKIEYHVRDALGRSWQCG
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCCC
TLQLDFVLPERLGAEYVTENNDRARPVMLHRAILGSLERFIGILIENHAGSFPLWLAPVQ
CEEEEEECHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVIMNITENQADYCREVAAKLQAAGFRAELDLRNEKIGYKIRDNSQYRFPYQIVVGDKEK
HEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCEECEEEEEECCCCC
QENKVAVRRKAEDLGSLDLDDFIAQLQQEITDALVNH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA