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The map label for this gene is rnc [H]

Identifier: 161869625

GI number: 161869625

Start: 652814

End: 653746

Strand: Direct

Name: rnc [H]

Synonym: NMCC_0642

Alternate gene names: 161869625

Gene position: 652814-653746 (Clockwise)

Preceding gene: 161869622

Following gene: 161869627

Centisome position: 30.32

GC content: 53.48

Gene sequence:

>933_bases
ATGCAGCGGTCGAGTGCCGAGGAAAGTGCTTGTGCAAATGCGTTCATTGCGGGAATACGTTGGGGGAAAACTTGCGGATT
TTACCACGATTCTTGCGTTGTCGGCAGACGGCGGCGGTTTGGTGGTACAATGTGCGCCGTTTGCAGCCTTAAGGTGTTTC
TGTATTTTTGGAGTATGGAAACGCATTCGGGCTGTTTTTTGCGGAAGACGGTAATGAAAGACGATGTTTTGAAACAGCAG
GCACACGCGGCGATACAGAAGAAACTGGGCTATGCGTTCCGCGATATTTCGCTTTTGCGGCAGGCTTTGACGCACAGGAG
CTGCCATACGAAACATAATGAACGGTTTGAGTTTGTCGGCGATTCGATTTTGAATTATACGGTGGCACGGATGCTGTTTG
ACGCGTTTCCGAAGTTGACCGAGGGCGAGTTGTCGCGGTTGCGGGCGAGTCTGGTCAATGAGGGCGTGCTGGCGGAAATG
GCGGCGGAAATGGATGTCGGAGAAGGCTTGTATTTGGGGGCGGGCGAGTTGAAGAGCGGCGGCTTTAGACGGCCTTCGAT
ACTGGCGGACGCGATGGAGGCGATGTTTGCCGCCGTCAGCTTCGATGCCGATTTCAACACGGCGGAAAAGGTGGTACGCC
ATTTGTTTGCCGATCGAGTCCGGTGTGCCGATTTCCAAAATCAGGCAAAAGACGGCAAAACTGCTTTGCAGGAGGCGTTG
CAGGCGCGCCGTTTCGCTTTGCCGAAATACCGTATCGAAGAGCAAATCGGCCATGCCAACGACAGTATGTTTGTCATTTC
CTGCGATTTGGGCGAACTGGGTTTCGTGTGCTATGCCAAAGGGACGAGCCGCAAGGCGGCGGAACAGGAGGCGGCGAAAG
AGGCTTTGAAATGGCTGGAAAAGAAGCTGCCGCTGAAGAAGAAAAAGAAATGA

Upstream 100 bases:

>100_bases
GCCGCTGAAGAAACGCCAGCCGCTGTCGTTTTCAAAAACGGGGGCTTCGCGGTAGAGGAAGCCGACGGGCTGGTTTTGTT
TGGCGACGGTGTTGGTGGCG

Downstream 100 bases:

>100_bases
GGCGGCGCGTGAATATGCCGTCTGAAATATGGATATGAAAGCGAATATGGATATTGAAACCTTCCTTGCAGGGGAACGTG
CCGCCGACGGATACCGTTGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MQRSSAEESACANAFIAGIRWGKTCGFYHDSCVVGRRRRFGGTMCAVCSLKVFLYFWSMETHSGCFLRKTVMKDDVLKQQ
AHAAIQKKLGYAFRDISLLRQALTHRSCHTKHNERFEFVGDSILNYTVARMLFDAFPKLTEGELSRLRASLVNEGVLAEM
AAEMDVGEGLYLGAGELKSGGFRRPSILADAMEAMFAAVSFDADFNTAEKVVRHLFADRVRCADFQNQAKDGKTALQEAL
QARRFALPKYRIEEQIGHANDSMFVISCDLGELGFVCYAKGTSRKAAEQEAAKEALKWLEKKLPLKKKKK

Sequences:

>Translated_310_residues
MQRSSAEESACANAFIAGIRWGKTCGFYHDSCVVGRRRRFGGTMCAVCSLKVFLYFWSMETHSGCFLRKTVMKDDVLKQQ
AHAAIQKKLGYAFRDISLLRQALTHRSCHTKHNERFEFVGDSILNYTVARMLFDAFPKLTEGELSRLRASLVNEGVLAEM
AAEMDVGEGLYLGAGELKSGGFRRPSILADAMEAMFAAVSFDADFNTAEKVVRHLFADRVRCADFQNQAKDGKTALQEAL
QARRFALPKYRIEEQIGHANDSMFVISCDLGELGFVCYAKGTSRKAAEQEAAKEALKWLEKKLPLKKKKK
>Mature_310_residues
MQRSSAEESACANAFIAGIRWGKTCGFYHDSCVVGRRRRFGGTMCAVCSLKVFLYFWSMETHSGCFLRKTVMKDDVLKQQ
AHAAIQKKLGYAFRDISLLRQALTHRSCHTKHNERFEFVGDSILNYTVARMLFDAFPKLTEGELSRLRASLVNEGVLAEM
AAEMDVGEGLYLGAGELKSGGFRRPSILADAMEAMFAAVSFDADFNTAEKVVRHLFADRVRCADFQNQAKDGKTALQEAL
QARRFALPKYRIEEQIGHANDSMFVISCDLGELGFVCYAKGTSRKAAEQEAAKEALKWLEKKLPLKKKKK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=27.6315789473684, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=27.6315789473684, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788920, Length=216, Percent_Identity=49.537037037037, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17506883, Length=200, Percent_Identity=27.5, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=200, Percent_Identity=27.5, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137682, Length=223, Percent_Identity=27.8026905829596, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 34755; Mature: 34755

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCC
>Mature Secondary Structure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HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA