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The map label for this gene is era [H]

Identifier: 161869627

GI number: 161869627

Start: 653781

End: 654716

Strand: Direct

Name: era [H]

Synonym: NMCC_0644

Alternate gene names: 161869627

Gene position: 653781-654716 (Clockwise)

Preceding gene: 161869625

Following gene: 161869640

Centisome position: 30.36

GC content: 52.14

Gene sequence:

>936_bases
ATGAAAGCGAATATGGATATTGAAACCTTCCTTGCAGGGGAACGTGCCGCCGACGGATACCGTTGCGGCTTCGTGGCGAT
TGTCGGTCGTCCGAACGTGGGCAAATCAACGCTGATGAACCATCTCATCGGTCAGAAAATCAGCATCACCAGCAAAAAGG
CGCAGACGACGCGCAACCGCGTAACGGGGATTTATACCGACGATACCGCGCAGTTTGTGTTTGTCGATACGCCCGGTTTT
CAAACCGACCACCGCAACGCGCTCAACGACCGTTTGAATCAAAACGTTACCGAGGCACTCGGCGGTGTGGATGCCGTGGT
TTTCGTCGTGGAGGCGATGCGCTTTACCGATGCCGACCGAGTCGTGTTGAAACAACTGCCCAAGCACACGCCGGTCGTTT
TAGTGGTCAACAAAATTGACAAGGACAAGGCGAAAGACCGTTACGCGTTGGAGGCGTTTGTTGCCCAGGTGCGCGCCGAA
TTTGAATTTGCGGCAGCGGAGGCAGTCAGCGCGAAACACGGATTGCGGATTGCCAACCTGTTGGAGCTGATTAAACCGTA
TCTGCCCGAAAGCGTGCCGATGTATCCCGAAGACATGGTTACGGACAAATCGGCGCGTTTTTTAGCGATGGAAATCGTGC
GTGAAAAATTGTTCCGCTATTTGGGCGAGGAATTGCCTTATGCGATGAACGTCGAAGTGGAGCAGTTTGAAGAGGAAGAC
GGTTTAAACCGCATCTATATCGCCGTTTTGGTCGATAAGGAAAGCCAAAAGGCGATTTTAATCGGCAAAGGCGGGGAGCG
TTTGAAGAAAATTTCCACCGAAGCGCGGTTGGATATGGAAAAACTGTTTGATACCAAAGTGTTTTTGAAAGTGTGGGTCA
AAGTCAAATCCGGTTGGGCGGACGACATCCGCTTCCTGCGCGAGCTGGGTTTGTAG

Upstream 100 bases:

>100_bases
GAGGCGGCGAAAGAGGCTTTGAAATGGCTGGAAAAGAAGCTGCCGCTGAAGAAGAAAAAGAAATGAGGCGGCGCGTGAAT
ATGCCGTCTGAAATATGGAT

Downstream 100 bases:

>100_bases
TTTTTCTTGCTGAACTTTACGCAAATGCCGTCCGAACAGGTTTCAGACGGCATTTTGTTTCAATCGGGAATATCTTTGTT
AAAAACGGGTTGATATTATC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKANMDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGIYTDDTAQFVFVDTPGF
QTDHRNALNDRLNQNVTEALGGVDAVVFVVEAMRFTDADRVVLKQLPKHTPVVLVVNKIDKDKAKDRYALEAFVAQVRAE
FEFAAAEAVSAKHGLRIANLLELIKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEED
GLNRIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIRFLRELGL

Sequences:

>Translated_311_residues
MKANMDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGIYTDDTAQFVFVDTPGF
QTDHRNALNDRLNQNVTEALGGVDAVVFVVEAMRFTDADRVVLKQLPKHTPVVLVVNKIDKDKAKDRYALEAFVAQVRAE
FEFAAAEAVSAKHGLRIANLLELIKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEED
GLNRIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIRFLRELGL
>Mature_311_residues
MKANMDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGIYTDDTAQFVFVDTPGF
QTDHRNALNDRLNQNVTEALGGVDAVVFVVEAMRFTDADRVVLKQLPKHTPVVLVVNKIDKDKAKDRYALEAFVAQVRAE
FEFAAAEAVSAKHGLRIANLLELIKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEED
GLNRIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIRFLRELGL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=321, Percent_Identity=27.1028037383178, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788919, Length=297, Percent_Identity=46.4646464646465, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI87082120, Length=191, Percent_Identity=30.3664921465969, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646434, Length=311, Percent_Identity=29.5819935691318, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35078; Mature: 35078

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKANMDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNR
CCCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHHH
VTGIYTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDAVVFVVEAMRFTDADR
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCHHH
VVLKQLPKHTPVVLVVNKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANL
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LELIKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEED
HHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCC
GLNRIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWA
CCCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DDIRFLRELGL
HHHHHHHHHCC
>Mature Secondary Structure
MKANMDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNR
CCCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHHH
VTGIYTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDAVVFVVEAMRFTDADR
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCHHH
VVLKQLPKHTPVVLVVNKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANL
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LELIKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEED
HHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHCCC
GLNRIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWA
CCCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DDIRFLRELGL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]