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The map label for this gene is nhaC [H]

Identifier: 161869464

GI number: 161869464

Start: 494352

End: 495704

Strand: Direct

Name: nhaC [H]

Synonym: NMCC_0476

Alternate gene names: 161869464

Gene position: 494352-495704 (Clockwise)

Preceding gene: 161869463

Following gene: 161869466

Centisome position: 22.96

GC content: 54.84

Gene sequence:

>1353_bases
ATGCCGCGCGGTGAGGCACTTGCCGTCGTCGTCGCTCTGATTGCCGCGATGGGCTATACCATCATTTCATTGGAGTGGCT
GCCGCATATGTCCATTATTGCCGCCATCGTCGTGCTGATTTTGTACGGCTTGGCGCGCGGTTTGAAATACAACGATATGC
AGCAGGGCATGATAGGCGCGTTGAATCAGGGTATGGGCGCGATTTACCTGTTTTTCTTCATCGGGCTGATGGTCAGCGCG
CTGATGATGAGCGGTGCGATTCCGACGCTGATGTATTACGGTTTCGGGCTGATTTCCCCGACTTATTTTTATTTTTCCGC
TTTCGCGCTGTGTTCCGTCATCGGCGTGTCCATCGGCAGCAGCCTGACCACCTGCGCCACCGTCGGCGTTGCCTTTATGG
GGATGGCGGCGGCGTTTCATGCCGATATGGCGATGACGGCGGGCGCGATTGTTTCCGGTGCGTTTTTCGGCGACAAAATG
TCCCCGCTTTCCGACACCACGGGCATTTCCGCGTCCATCGTCGGCATCGACCTGTTTGAGCACATCAAAAATATGATGTA
CACCACCATTCCCGCGTGGCTCATCAGTGCGGCACTGATGCTGTGGCTTCTTCCCAGTGTCGCCGCGCAGGATTTGAACA
GCGTCGAATCCTTCCGCAGCCAGCTTGAAGCCACGGGATTGGTGCACGGCTATTCGCTGATTCCGTTTGCACTGTTGGTC
GTTTTGGCATTGATGCGCGTCAATGCCGTGGTCGCCATGCTCTTTACCGTCATGGTTGCCGTTGCCGTAACGTATCTGCA
CAGTACGCCCGATCTGCGTCAGCTCGGCGCGTGGTTTTACGGCGGCTACAAACTCGAAGGCGAAGCGTTTAAAGACATTG
CCAAACTCATTTCGCGCGGCGGTTTGGAAAGTATGTTCTTCACGCAGACTATCGTTATCCTCGGGATGAGTTTGGGCGGG
CTGTTGTTTGCACTGGGCGCGATTCCTTCCCTGCTGGATGCCGTCCGCAGCTTTTTGACGAATGCCGGGCGTGCCACATT
CAGCGTTGCTATGACTTCGGTCGGGGTTAATTTCCTGATTGGCGAGCAATATTTGAGTATTTTGTTGTCGGGTGAAACGT
TCAAACCCGTTTACGATAAGCTCGGTCTGCATTCGCGCAACCTGTCTCGGACGCTCGAAGATGCGGGGACGGTCATCAAC
CCGCTTGTTCCGTGGAGCGTGTGCGGCGTATTTATCAGCCATGCGCTGGGTGTGCCGGTCTGGGAATATCTGCCCTATGC
CTTTTTCTGCTATTTGAGTTTGGCTTTGACCCTGTTATTCGGCTGGACGGGGCTGACTTTGAGCAAAAAATAA

Upstream 100 bases:

>100_bases
CTGAAAACGTTGGGCGGATTCGGTATGGTGTGTTAGAATCCGTTAACTTTATATCAAATCGGGCAAAGAATCATGTTTGC
TTTCAAATCCTTAACTCGAT

Downstream 100 bases:

>100_bases
GCGGATAAGCAAAATGCCGTCTGAACCTGTTTTCCGGCTTCAGACGGCATTTTTATGTTTGGCGGATGGGGCGGATTGAA
ACAGAAAACGCCCGTACCGT

Product: transmembrane transport protein

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYNDMQQGMIGALNQGMGAIYLFFFIGLMVSA
LMMSGAIPTLMYYGFGLISPTYFYFSAFALCSVIGVSIGSSLTTCATVGVAFMGMAAAFHADMAMTAGAIVSGAFFGDKM
SPLSDTTGISASIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPSVAAQDLNSVESFRSQLEATGLVHGYSLIPFALLV
VLALMRVNAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFKDIAKLISRGGLESMFFTQTIVILGMSLGG
LLFALGAIPSLLDAVRSFLTNAGRATFSVAMTSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVIN
PLVPWSVCGVFISHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKK

Sequences:

>Translated_450_residues
MPRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYNDMQQGMIGALNQGMGAIYLFFFIGLMVSA
LMMSGAIPTLMYYGFGLISPTYFYFSAFALCSVIGVSIGSSLTTCATVGVAFMGMAAAFHADMAMTAGAIVSGAFFGDKM
SPLSDTTGISASIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPSVAAQDLNSVESFRSQLEATGLVHGYSLIPFALLV
VLALMRVNAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFKDIAKLISRGGLESMFFTQTIVILGMSLGG
LLFALGAIPSLLDAVRSFLTNAGRATFSVAMTSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVIN
PLVPWSVCGVFISHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKK
>Mature_449_residues
PRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYNDMQQGMIGALNQGMGAIYLFFFIGLMVSAL
MMSGAIPTLMYYGFGLISPTYFYFSAFALCSVIGVSIGSSLTTCATVGVAFMGMAAAFHADMAMTAGAIVSGAFFGDKMS
PLSDTTGISASIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPSVAAQDLNSVESFRSQLEATGLVHGYSLIPFALLVV
LALMRVNAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFKDIAKLISRGGLESMFFTQTIVILGMSLGGL
LFALGAIPSLLDAVRSFLTNAGRATFSVAMTSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVINP
LVPWSVCGVFISHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKK

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48246; Mature: 48115

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYNDMQQGMIGA
CCCHHHHHHHHHHHHHCHHHEEHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LNQGMGAIYLFFFIGLMVSALMMSGAIPTLMYYGFGLISPTYFYFSAFALCSVIGVSIGS
HHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SLTTCATVGVAFMGMAAAFHADMAMTAGAIVSGAFFGDKMSPLSDTTGISASIVGIDLFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
HIKNMMYTTIPAWLISAALMLWLLPSVAAQDLNSVESFRSQLEATGLVHGYSLIPFALLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLALMRVNAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFKDIAKLISRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEECCHHHHHHHHHHHCC
GLESMFFTQTIVILGMSLGGLLFALGAIPSLLDAVRSFLTNAGRATFSVAMTSVGVNFLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHH
GEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVINPLVPWSVCGVFISHALGVPV
HHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCH
WEYLPYAFFCYLSLALTLLFGWTGLTLSKK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]