Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 161869354

GI number: 161869354

Start: 361515

End: 362807

Strand: Reverse

Name: accC [H]

Synonym: NMCC_0360

Alternate gene names: 161869354

Gene position: 362807-361515 (Counterclockwise)

Preceding gene: 161869355

Following gene: 161869353

Centisome position: 16.85

GC content: 58.16

Gene sequence:

>1293_bases
ATGGGCATTGCCACCGTCGCCGTGCATTCCGAGGCCGACAAAGACAGCCTGCACGTCAAACTCGCCGACGAATCCGTGTG
CATCGGCCCTGCCGCTTCCGCGCAAAGCTACCTTAACGTCCCCGCCATTATCGCCGCCGCCGAAGTAAGCTGCGCGGACG
CTGTCCATCCGGGCTACGGTTTCCTTGCCGAAAACGCCGATTTCGCCGAACAGGTCGAGCAGTCCGGCTTTACCTTTATC
GGCCCGAAACCCGACACCATCCGCCTGATGGGCGACAAAGTCTCCGCCAAACACGCGATGATAGCGGCAGGCGTACCCTG
CGTCCCCGGTTCTGACGGCGCATTGCCCGACGACGGCGAAGAAATCCTCAAAATCGCCGATAAAGTCGGTTATCCCGTCA
TTATCAAAGCCTCCGGTGGCGGCGGCGGTCGCGGTATGCGCGTGGTCGAGAAAAAAGAAGACCTCCTCCAATCTGTCGAA
ATGACCAAGGCCGAAGCGGGCGCGGCATTCGGCAACCCGATGGTTTACATGGAACGCTATTTGCAACGTCCGCGCCACGT
CGAAATCCAAGTGATTGCCGACGAACACGGCAACGCCATCTACCTTGCCGAGCGCGACTGTTCGCTGCAACGCCGCCACC
AAAAAGTCATCGAGGAAGCACCGGCTCCGTTCATCACTGAAAAAGAACGCGCCAAAATCGGCAACGCCTGTGCCGATGCC
TGCAAACGCATCGGCTACCGGGGCGCGGGTACGTTTGAGTTTTTATACGAAGACGGCGAATTTTTCTTTATCGAGATGAA
CACGCGCGTTCAGGTCGAGCATCCGGTTACCGAGCTCATCACCGGCGTGGACATCGTGCAGGAGCAACTCCGCATCGCCG
CCGGCCTGCCTTTGCAATACAAACAAAAGGATATTCAAGTCGAAGGCCACGCGTTTGAGTGCCGTATCAACGCCGAAGAC
CCATACAACTTCATCCCCAGCCCGGGCCCGATTGAAAGCTGCCACCTGCCCGGCGGCTTCGGTATCCGCGTGGACAGCCA
CATTTACCAAGGCTACCGCATCCCACCGTACTACGACAGCCTGATCGGCAAAATCTGCGTACACGGCAAAACGCGTGAAC
AGGCAATGGCGAAAATGCGCGTCGCACTCGCCGAGCTGGCGGTAACCGGCATCAAAACCAATACGCCGCTTCACCGCGAC
CTGTTCGCCGATGCGGGTTTCCAAAAAGGCGGTGTCAGCATCCACTATTTGGAACACTGGCTGGAAGATCGCAAAGCCAA
ACAGGACAAGTAA

Upstream 100 bases:

>100_bases
ACGGGTTGCCGGAACCACAGGAACAGTCATCATGCTGAAAAAAGTTTTAATCGCCAACCGAGGCGAAATCGCATTACGCG
TACTCCGTGCCTGCCGCGAA

Downstream 100 bases:

>100_bases
ACCGCCGCCGATATGCCGTCTGAAACAGTTTGTCCGTTTTCAGACGGCATTTCCGTTACACACCCATCCCCTTATACAGT
ACGACCCTATTCCGAAGGTC

Product: acetyl-CoA carboxylase biotin carboxylase component

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGIATVAVHSEADKDSLHVKLADESVCIGPAASAQSYLNVPAIIAAAEVSCADAVHPGYGFLAENADFAEQVEQSGFTFI
GPKPDTIRLMGDKVSAKHAMIAAGVPCVPGSDGALPDDGEEILKIADKVGYPVIIKASGGGGGRGMRVVEKKEDLLQSVE
MTKAEAGAAFGNPMVYMERYLQRPRHVEIQVIADEHGNAIYLAERDCSLQRRHQKVIEEAPAPFITEKERAKIGNACADA
CKRIGYRGAGTFEFLYEDGEFFFIEMNTRVQVEHPVTELITGVDIVQEQLRIAAGLPLQYKQKDIQVEGHAFECRINAED
PYNFIPSPGPIESCHLPGGFGIRVDSHIYQGYRIPPYYDSLIGKICVHGKTREQAMAKMRVALAELAVTGIKTNTPLHRD
LFADAGFQKGGVSIHYLEHWLEDRKAKQDK

Sequences:

>Translated_430_residues
MGIATVAVHSEADKDSLHVKLADESVCIGPAASAQSYLNVPAIIAAAEVSCADAVHPGYGFLAENADFAEQVEQSGFTFI
GPKPDTIRLMGDKVSAKHAMIAAGVPCVPGSDGALPDDGEEILKIADKVGYPVIIKASGGGGGRGMRVVEKKEDLLQSVE
MTKAEAGAAFGNPMVYMERYLQRPRHVEIQVIADEHGNAIYLAERDCSLQRRHQKVIEEAPAPFITEKERAKIGNACADA
CKRIGYRGAGTFEFLYEDGEFFFIEMNTRVQVEHPVTELITGVDIVQEQLRIAAGLPLQYKQKDIQVEGHAFECRINAED
PYNFIPSPGPIESCHLPGGFGIRVDSHIYQGYRIPPYYDSLIGKICVHGKTREQAMAKMRVALAELAVTGIKTNTPLHRD
LFADAGFQKGGVSIHYLEHWLEDRKAKQDK
>Mature_429_residues
GIATVAVHSEADKDSLHVKLADESVCIGPAASAQSYLNVPAIIAAAEVSCADAVHPGYGFLAENADFAEQVEQSGFTFIG
PKPDTIRLMGDKVSAKHAMIAAGVPCVPGSDGALPDDGEEILKIADKVGYPVIIKASGGGGGRGMRVVEKKEDLLQSVEM
TKAEAGAAFGNPMVYMERYLQRPRHVEIQVIADEHGNAIYLAERDCSLQRRHQKVIEEAPAPFITEKERAKIGNACADAC
KRIGYRGAGTFEFLYEDGEFFFIEMNTRVQVEHPVTELITGVDIVQEQLRIAAGLPLQYKQKDIQVEGHAFECRINAEDP
YNFIPSPGPIESCHLPGGFGIRVDSHIYQGYRIPPYYDSLIGKICVHGKTREQAMAKMRVALAELAVTGIKTNTPLHRDL
FADAGFQKGGVSIHYLEHWLEDRKAKQDK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=434, Percent_Identity=46.7741935483871, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI189095269, Length=424, Percent_Identity=46.4622641509434, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI65506442, Length=424, Percent_Identity=46.4622641509434, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=424, Percent_Identity=46.4622641509434, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=425, Percent_Identity=44.9411764705882, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI106049295, Length=425, Percent_Identity=44.9411764705882, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI106049292, Length=425, Percent_Identity=44.9411764705882, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI38679974, Length=458, Percent_Identity=32.5327510917031, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679960, Length=458, Percent_Identity=32.5327510917031, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679977, Length=458, Percent_Identity=32.5327510917031, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=458, Percent_Identity=32.5327510917031, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679971, Length=458, Percent_Identity=32.5327510917031, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI134142062, Length=466, Percent_Identity=31.3304721030043, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1789654, Length=421, Percent_Identity=68.4085510688836, Blast_Score=573, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17567343, Length=421, Percent_Identity=47.2684085510689, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=420, Percent_Identity=45.9523809523809, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17562816, Length=424, Percent_Identity=43.6320754716981, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI133931226, Length=466, Percent_Identity=30.2575107296137, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=454, Percent_Identity=30.8370044052863, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=454, Percent_Identity=30.8370044052863, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=423, Percent_Identity=43.4988179669031, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319695, Length=427, Percent_Identity=42.8571428571429, Blast_Score=312, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6321376, Length=427, Percent_Identity=43.559718969555, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6324343, Length=480, Percent_Identity=31.4583333333333, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=454, Percent_Identity=31.9383259911894, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24651757, Length=427, Percent_Identity=46.3700234192037, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=46.2287104622871, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652224, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652222, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652220, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652218, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652212, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652210, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652214, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI19921944, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652216, Length=425, Percent_Identity=46.5882352941176, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI161076409, Length=459, Percent_Identity=31.5904139433551, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI161076407, Length=459, Percent_Identity=31.5904139433551, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586460, Length=459, Percent_Identity=31.5904139433551, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586458, Length=459, Percent_Identity=31.5904139433551, Blast_Score=218, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 46948; Mature: 46817

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIATVAVHSEADKDSLHVKLADESVCIGPAASAQSYLNVPAIIAAAEVSCADAVHPGYG
CCEEEEEEECCCCCCCEEEEECCCCEEECCCCCCHHHCCCCHHEEEHHCCHHHCCCCCCC
FLAENADFAEQVEQSGFTFIGPKPDTIRLMGDKVSAKHAMIAAGVPCVPGSDGALPDDGE
EEECCCHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHH
EILKIADKVGYPVIIKASGGGGGRGMRVVEKKEDLLQSVEMTKAEAGAAFGNPMVYMERY
HHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQRPRHVEIQVIADEHGNAIYLAERDCSLQRRHQKVIEEAPAPFITEKERAKIGNACADA
HCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHH
CKRIGYRGAGTFEFLYEDGEFFFIEMNTRVQVEHPVTELITGVDIVQEQLRIAAGLPLQY
HHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEE
KQKDIQVEGHAFECRINAEDPYNFIPSPGPIESCHLPGGFGIRVDSHIYQGYRIPPYYDS
CCCCEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCHHHHH
LIGKICVHGKTREQAMAKMRVALAELAVTGIKTNTPLHRDLFADAGFQKGGVSIHYLEHW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
LEDRKAKQDK
HHHHHCCCCC
>Mature Secondary Structure 
GIATVAVHSEADKDSLHVKLADESVCIGPAASAQSYLNVPAIIAAAEVSCADAVHPGYG
CEEEEEEECCCCCCCEEEEECCCCEEECCCCCCHHHCCCCHHEEEHHCCHHHCCCCCCC
FLAENADFAEQVEQSGFTFIGPKPDTIRLMGDKVSAKHAMIAAGVPCVPGSDGALPDDGE
EEECCCHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHH
EILKIADKVGYPVIIKASGGGGGRGMRVVEKKEDLLQSVEMTKAEAGAAFGNPMVYMERY
HHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQRPRHVEIQVIADEHGNAIYLAERDCSLQRRHQKVIEEAPAPFITEKERAKIGNACADA
HCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHH
CKRIGYRGAGTFEFLYEDGEFFFIEMNTRVQVEHPVTELITGVDIVQEQLRIAAGLPLQY
HHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEE
KQKDIQVEGHAFECRINAEDPYNFIPSPGPIESCHLPGGFGIRVDSHIYQGYRIPPYYDS
CCCCEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCHHHHH
LIGKICVHGKTREQAMAKMRVALAELAVTGIKTNTPLHRDLFADAGFQKGGVSIHYLEHW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
LEDRKAKQDK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]