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The map label for this gene is metR [H]

Identifier: 161869137

GI number: 161869137

Start: 131702

End: 132631

Strand: Reverse

Name: metR [H]

Synonym: NMCC_0131

Alternate gene names: 161869137

Gene position: 132631-131702 (Counterclockwise)

Preceding gene: 161869143

Following gene: 161869131

Centisome position: 6.16

GC content: 54.3

Gene sequence:

>930_bases
ATGGATTCCATTATCGAATTGCGCCACCTCAAAACCCTGCTGGCACTTGAAGAAACCGGCAGCGTCTCCCTTGCCGCCAA
ACGGGTTTTCCTTACCCAATCCGCCCTTTCCCACCAGATCCGTATGCTCGAAAACCACTACGGCACGCCGCTGTTCGAAC
GCAAATCCACGCCCTTGCGCTTTACCCCGGTGGGCGAAAGGCTGCTGCGCCTCGCCCACGAACTGATACCTCAAGTTGCT
GTTGCAGAATGGGATTTAGCGCGAATCACGGAAGGAGAGGCGGGAGAGCTGCGGATTGCCGTCGAATGCCATACCTGTTT
CGACTGGCTGATGCCCGCCATGGGCGAATTCCGCCCGATGTGGCCCCAAGTCGAATTGGATATCGTATCGGGATTCCAAG
CGGATCCCGTCGGACTGCTGCTGCAACACCGTGCCGACCTTGCCATTGTTTCCGAAGCGGAAAAACAAAACGGTATTTCT
TTCCAACCGCTGTTTGCCTACGAAATGGTCGGCATTTGCGCACCAGACCATCCGCTTGCCGCCAAAAACGTTTGGACGGC
GGAAGACTTTATCGGGGAAACCCTGATTACTTATCCCGTTCCCGACGAGATGCTGGATTTGCCCAAAAAAATCCTGATTC
CGAAAAACATCAACCCGCCGCGCCGACACAGCGAACTGACCATCGCCATTATCCAACTGGTTGCCAGCAGACGTGGCATT
GCCGCCCTTCCTTATTGGACAGTCATGCCCTACCTTGAAAAAGGCTATGTCGTCCACCGCCAAATTACTGCCGACGGACT
GCAAAGCAAACTGTATGCCGCCATCCGTACCGAAGATACGGACAAGAGCTATCTGAACAATTTTTGCCAAATCATACGCG
AACGCGGTTTTGCAGATTTGCCCGGACTGAGCGAACTGGAATCGGTCTGA

Upstream 100 bases:

>100_bases
CATTCTAATCGCAAAATGTCCGGAATTCACATTTTTCCGATTTGCACCCGCATATGAATTATTTTAATATGCGCCGGTTC
AATATGCCGTCTGAAGCCCC

Downstream 100 bases:

>100_bases
CCCCTTATTCAACCATACCCGGCAGTTTTTCTATTTTTTCATGTATAGTGGATTAACAAAAACCAGTACAGCGTTGCCTC
GCCTTGCCATACTATTTGTA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MDSIIELRHLKTLLALEETGSVSLAAKRVFLTQSALSHQIRMLENHYGTPLFERKSTPLRFTPVGERLLRLAHELIPQVA
VAEWDLARITEGEAGELRIAVECHTCFDWLMPAMGEFRPMWPQVELDIVSGFQADPVGLLLQHRADLAIVSEAEKQNGIS
FQPLFAYEMVGICAPDHPLAAKNVWTAEDFIGETLITYPVPDEMLDLPKKILIPKNINPPRRHSELTIAIIQLVASRRGI
AALPYWTVMPYLEKGYVVHRQITADGLQSKLYAAIRTEDTDKSYLNNFCQIIRERGFADLPGLSELESV

Sequences:

>Translated_309_residues
MDSIIELRHLKTLLALEETGSVSLAAKRVFLTQSALSHQIRMLENHYGTPLFERKSTPLRFTPVGERLLRLAHELIPQVA
VAEWDLARITEGEAGELRIAVECHTCFDWLMPAMGEFRPMWPQVELDIVSGFQADPVGLLLQHRADLAIVSEAEKQNGIS
FQPLFAYEMVGICAPDHPLAAKNVWTAEDFIGETLITYPVPDEMLDLPKKILIPKNINPPRRHSELTIAIIQLVASRRGI
AALPYWTVMPYLEKGYVVHRQITADGLQSKLYAAIRTEDTDKSYLNNFCQIIRERGFADLPGLSELESV
>Mature_309_residues
MDSIIELRHLKTLLALEETGSVSLAAKRVFLTQSALSHQIRMLENHYGTPLFERKSTPLRFTPVGERLLRLAHELIPQVA
VAEWDLARITEGEAGELRIAVECHTCFDWLMPAMGEFRPMWPQVELDIVSGFQADPVGLLLQHRADLAIVSEAEKQNGIS
FQPLFAYEMVGICAPDHPLAAKNVWTAEDFIGETLITYPVPDEMLDLPKKILIPKNINPPRRHSELTIAIIQLVASRRGI
AALPYWTVMPYLEKGYVVHRQITADGLQSKLYAAIRTEDTDKSYLNNFCQIIRERGFADLPGLSELESV

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=304, Percent_Identity=43.421052631579, Blast_Score=241, Evalue=3e-65,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=28.2722513089005, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787530, Length=181, Percent_Identity=29.2817679558011, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786401, Length=169, Percent_Identity=28.4023668639053, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI157672245, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790208, Length=184, Percent_Identity=29.3478260869565, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789204, Length=270, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788887, Length=294, Percent_Identity=25.8503401360544, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=24.6963562753036, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082024, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081904, Length=182, Percent_Identity=26.9230769230769, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786448, Length=194, Percent_Identity=28.8659793814433, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34822; Mature: 34822

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSIIELRHLKTLLALEETGSVSLAAKRVFLTQSALSHQIRMLENHYGTPLFERKSTPLR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
FTPVGERLLRLAHELIPQVAVAEWDLARITEGEAGELRIAVECHTCFDWLMPAMGEFRPM
ECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCC
WPQVELDIVSGFQADPVGLLLQHRADLAIVSEAEKQNGISFQPLFAYEMVGICAPDHPLA
CCCEEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
AKNVWTAEDFIGETLITYPVPDEMLDLPKKILIPKNINPPRRHSELTIAIIQLVASRRGI
CCCCCCHHHHHCCEEEECCCCHHHHCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
AALPYWTVMPYLEKGYVVHRQITADGLQSKLYAAIRTEDTDKSYLNNFCQIIRERGFADL
EECCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCC
PGLSELESV
CCHHHHHCC
>Mature Secondary Structure
MDSIIELRHLKTLLALEETGSVSLAAKRVFLTQSALSHQIRMLENHYGTPLFERKSTPLR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
FTPVGERLLRLAHELIPQVAVAEWDLARITEGEAGELRIAVECHTCFDWLMPAMGEFRPM
ECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCC
WPQVELDIVSGFQADPVGLLLQHRADLAIVSEAEKQNGISFQPLFAYEMVGICAPDHPLA
CCCEEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
AKNVWTAEDFIGETLITYPVPDEMLDLPKKILIPKNINPPRRHSELTIAIIQLVASRRGI
CCCCCCHHHHHCCEEEECCCCHHHHCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
AALPYWTVMPYLEKGYVVHRQITADGLQSKLYAAIRTEDTDKSYLNNFCQIIRERGFADL
EECCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCC
PGLSELESV
CCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]