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The map label for this gene is gnd [H]

Identifier: 161869034

GI number: 161869034

Start: 12994

End: 14406

Strand: Reverse

Name: gnd [H]

Synonym: NMCC_0017

Alternate gene names: 161869034

Gene position: 14406-12994 (Counterclockwise)

Preceding gene: 161869037

Following gene: 161869033

Centisome position: 0.67

GC content: 54.07

Gene sequence:

>1413_bases
ATGGGGCAAAACCTGATTTTGAATATGAACGATTGCGGATTTAAGGTTGTCGCCTACAACCGAACAATCGGTAAGGTGGA
CGAATTTTTAAACGGCGCGGCAAAAGGGACCGGTATTATCGGCGCGTATTCCCTGCAAGACTTGGTCGATAAGCTGGCAA
AACCAAGAAAAATTATGATGATGGTTCGCGCAGGTTCGGTGGTTGACGACTTTATCGAACAACTGCTTCCGCTGTTGGAA
GAAGGCGACATCATTATCGACGGCGGCAATGCCAATTACCCCGACACGACACGGCGGACACATTACCTTGCTGAAAAAGG
GATTTTGTTTGTCGGCGCGGGCGTATCCGGCGGCGAAGAAGGCGCGCGGCACGGCCCGTCCATTATGCCGGGCGGGGATA
AGCGCGCTTGGGAAGCCGTCAAACCGATTTTCCAGGCGATTGCCGCCAAAACGCCGCAGGGCGAACCGTGTTGCGACTGG
GTCGGCAAAGACGGTGCGGGGCATTTTGTCAAAATGGTGCATAACGGCATCGAATATGGCGATATGCAGTTGATTTGCGA
AGCGTACCAGTTCATGAAAGACGGCTTGGGGCTGTCTTACGACGAAATGTACCGCGTGTTTGCCGAGTGGAACAAAACCG
AGCTGGATTCTTATCTGATTGAAATCACAGCGGCAATTTTGGGCTATAAGGACGAAGGCGGCGAACCGCTGGTCGAGAAA
ATCCTCGATACGGCAGGGCAAAAAGGTACAGGCAAATGGACGGGCATCAATGCTTTGGATTTGGGTATTCCGCTGACGCT
GATTTCCGAAGCCGTATTCGCCCGCTGCGTTTCGTCGTTCAAAGAACAGCGCGTGCAGACCGGCAAACTGTTCGCCCGAA
CCGTTACGCCCGTCGAAGGCGGCAAACAAGAATGGGTCGAGGCGTTGAGACAGGCCCTGCTTGCATCTAAAATCATTTCC
TACGCACAAGGCTTTATGCTGATCCGCGAAGCGGGCGAAAGCTACGGCTGGGATTTGGACTACGGCAACACTGCGCTGCT
GTGGCGCGAGGGGTGCATCATTCGCAGCGCATTCTTAAGCAATATCCGCGACGCGTATGAAAACAATCCCGATTTGGTGT
TCTTGGGTGCGGATCCGTATTTCAAAAATATTTTGGAAAACTGCCTGCCGGCGTGGCGCAAGGTGGTTGCCAAGGCGGTC
GAATGCGGCATCCCTATGCCATGCATGGCTTCGGCGATTACGTTCTTGGACGGCTACACGACCGAACGTCTGCCTGCCAA
CCTCTTGCAGGCACAGCGCGACTACTTCGGCGCACACACTTACGAGCGCACCGACAAACCGCGCGGCGAGTTTTTCCATA
CCAACTGGACGGGCAAGGGCGGAGATACCGCTTCGACAACCTACGATATTTGA

Upstream 100 bases:

>100_bases
TAAACAAGTGTAAATCAGGTAGAGTTGCGGTCGATAAATTAAATCTATAACGGAGCTTCCTGCAATGAAAGGCGATATTG
GTGTAATCGGTTTAGCGGTT

Downstream 100 bases:

>100_bases
TTCCGTTGCCGAAATGCCGTCTGAACCGTTCAGACGGCATTTGTTTTGCAGGAAATAGAAAGATGTTCCAATGGCTTTAT
GATGTATTGTGGCTGCTTGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDFIEQLLPLLE
EGDIIIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEEGARHGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDW
VGKDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEK
ILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQALLASKIIS
YAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAV
ECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDI

Sequences:

>Translated_470_residues
MGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDFIEQLLPLLE
EGDIIIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEEGARHGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDW
VGKDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEK
ILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQALLASKIIS
YAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAV
ECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDI
>Mature_469_residues
GQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDFIEQLLPLLEE
GDIIIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEEGARHGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDWV
GKDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEKI
LDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQALLASKIISY
AQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAVE
CGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDI

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=63.1914893617021, Blast_Score=608, Evalue=1e-174,
Organism=Escherichia coli, GI1788341, Length=456, Percent_Identity=52.4122807017544, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=58.2627118644068, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6321695, Length=476, Percent_Identity=58.8235294117647, Blast_Score=564, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6321977, Length=476, Percent_Identity=58.6134453781513, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=60.3411513859275, Blast_Score=556, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51766; Mature: 51634

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMM
CCCCEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCHHEEH
MVRAGSVVDDFIEQLLPLLEEGDIIIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEE
HHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCC
GARHGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDWVGKDGAGHFVKMVHNGIEYG
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCC
DMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEG
HHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKQEWVEALRQALLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCEEEEEECCHHHHHHHHH
NIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAVECGIPMPCMASAITFLDGYT
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
TERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDI
CHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMM
CCCEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCHHEEH
MVRAGSVVDDFIEQLLPLLEEGDIIIDGGNANYPDTTRRTHYLAEKGILFVGAGVSGGEE
HHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCC
GARHGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDWVGKDGAGHFVKMVHNGIEYG
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCC
DMQLICEAYQFMKDGLGLSYDEMYRVFAEWNKTELDSYLIEITAAILGYKDEGGEPLVEK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEG
HHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKQEWVEALRQALLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCEEEEEECCHHHHHHHHH
NIRDAYENNPDLVFLGADPYFKNILENCLPAWRKVVAKAVECGIPMPCMASAITFLDGYT
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
TERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGKGGDTASTTYDI
CHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]