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The map label for this gene is lpxC [H]

Identifier: 161869037

GI number: 161869037

Start: 16085

End: 17008

Strand: Reverse

Name: lpxC [H]

Synonym: NMCC_0020

Alternate gene names: 161869037

Gene position: 17008-16085 (Counterclockwise)

Preceding gene: 161869040

Following gene: 161869034

Centisome position: 0.79

GC content: 53.57

Gene sequence:

>924_bases
ATGCTGCAAAGAACTTTGGCGAAATCCATCAGCGTTACCGGAGTCGGGCTGCATTCGGGCGAACGCGTCGCGCTGACCCT
GCACCCCGCGCCTGAAAACAGCGGGATTTCCTTCCGCCGTACCGATTTGGACGGCGAGATGGGCGAACAAATCAAACTGA
CCCCTTATTTGATCAACGATACCCGCCTTTCCTCCACCATCGTTACCGACAAAGGCGTGCGCGTCGGCACAATCGAACAC
ATTATGTCCGCGCTGTCCGCCTACGGCATCGACAATGCGCTGATTGAGCTGAACGCGCCCGAAATCCCGATTATGGACGG
CTCCAGCCTGCCGTTTATTTACCTTTTGCAAGATGCGGGCGTGGTCGATCAAAAGGCGCAAAAGCGTTTTTTGAAAATCC
TCAAGCCTGTCGAAATCAAAGAAGCGGGCAAATGGGTGCGCTTTACGCCGTATGACGGCTTTAAGGTAACGCTGACCATC
GAATTCGACCATCCGGTTTTCAACCGCAGCTCGCCCACTTTTGAAATTGATTTCGCCGGCAAATCCTACATCGACGAAAT
CGCGCGCGCGCGCACTTTCGGCTTTATGCACGAAGTGGAAATGATGCGCGCCCACAATCTGGGTTTGGGCGGCAATTTGA
ACAACGCCATCGTGATTGACGACACGGATGTCCTGAATCCTGAAGGCTTGCGCTATCCCGATGAGTTTGTGCGCCACAAA
ATCCTTGATGCCATCGGTGATTTGTATATCGTCGGACATCCGATTGTCGGCGCGTTTGAAGGCTACAAATCGGGACACGC
CATCAACAACGCACTCTTGCGCGCGGTTTTGGCAGACGAAACGGCTTACGACCGGGTGGAATTTGCCGACAGCGATGATT
TGCCCGACGCATTTCACGAGCTGAACATCAGAACTTGTGGATAA

Upstream 100 bases:

>100_bases
GAAAACAGATACATTGGCAAATACTATGGAAAAACATAGCTTGTTTTTCCGGTTTTATCGTATTATTCCAAAACTTACCC
CATTGATAAGGAAGCGGTTT

Downstream 100 bases:

>100_bases
CGCTTTCTGTTTTTTCCGGTAAATTCCTAAAACTTAAAATTTCATCATTCCCACAAGGACAAAAAACCAAAACAGCAACC
TAAAATTCGTCATTCCCACG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLINDTRLSSTIVTDKGVRVGTIEH
IMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAGVVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTI
EFDHPVFNRSSPTFEIDFAGKSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHK
ILDAIGDLYIVGHPIVGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHELNIRTCG

Sequences:

>Translated_307_residues
MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLINDTRLSSTIVTDKGVRVGTIEH
IMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAGVVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTI
EFDHPVFNRSSPTFEIDFAGKSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHK
ILDAIGDLYIVGHPIVGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHELNIRTCG
>Mature_307_residues
MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLINDTRLSSTIVTDKGVRVGTIEH
IMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAGVVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTI
EFDHPVFNRSSPTFEIDFAGKSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHK
ILDAIGDLYIVGHPIVGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHELNIRTCG

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=296, Percent_Identity=49.3243243243243, Blast_Score=319, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33987; Mature: 33987

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLIND
CCHHHHHHHCEEEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEEEEEC
TRLSSTIVTDKGVRVGTIEHIMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAG
CCCCEEEEECCCCEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCC
VVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTIEFDHPVFNRSSPTFEIDFAG
CCCHHHHHHHHHHHCCCCCHHCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEEECC
KSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
ILDAIGDLYIVGHPIVGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHE
HHHHHCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHCEEEECCCCCCCCHHHH
LNIRTCG
CCEEECC
>Mature Secondary Structure
MLQRTLAKSISVTGVGLHSGERVALTLHPAPENSGISFRRTDLDGEMGEQIKLTPYLIND
CCHHHHHHHCEEEEEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEEEEEC
TRLSSTIVTDKGVRVGTIEHIMSALSAYGIDNALIELNAPEIPIMDGSSLPFIYLLQDAG
CCCCEEEEECCCCEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEECCC
VVDQKAQKRFLKILKPVEIKEAGKWVRFTPYDGFKVTLTIEFDHPVFNRSSPTFEIDFAG
CCCHHHHHHHHHHHCCCCCHHCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEEECC
KSYIDEIARARTFGFMHEVEMMRAHNLGLGGNLNNAIVIDDTDVLNPEGLRYPDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
ILDAIGDLYIVGHPIVGAFEGYKSGHAINNALLRAVLADETAYDRVEFADSDDLPDAFHE
HHHHHCCEEEECCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHCEEEECCCCCCCCHHHH
LNIRTCG
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA