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The map label for this gene is lutP [H]

Identifier: 161526310

GI number: 161526310

Start: 3432846

End: 3434510

Strand: Reverse

Name: lutP [H]

Synonym: Bmul_3141

Alternate gene names: 161526310

Gene position: 3434510-3432846 (Counterclockwise)

Preceding gene: 161526312

Following gene: 161526309

Centisome position: 99.6

GC content: 67.63

Gene sequence:

>1665_bases
ATGAATCCCACAGTCGCTCTACCGCCCGGCATCGTCTTCGCGCAGCCGCTGACGCCCGTCGCCGGCTCGCTGCTGCTCTC
GTTCCTCGTCGCCGTGATTCCGATCGCCGTCGCGCTGATCGCGCTCGGCGTGCTGCGCCGCCCGGCATGGCAGGCGTCGC
TCGCCGGGCTCGTCGCGGGTCTCGCGGTCGCGATCGGTGCGTGGGGGATGCCGGCCGGTCTCGCGTTCAATGCGGTCGGC
GCCGGGATGGCGCTCGCCGTCGTGCCCGTGATGTGGATCGTCTTCAATGCGCTGCTGCTATACAACATCGCGGTGAAGTC
GGGCCGCTTCGACCAGTTCCGGCAATGGATGCTCGACAATCTGCCCGACGACCGCCGCCTCGTGCTGCTGGTCGTCGCGT
TCTCGTTCGGCTGTCTGCTCGAAGGGATCTCCGGCTTCGGCACGCCGGTCGCGATCACGAGCGCGCTGCTGATCGCGCTC
GGCTTTCCCGCGCTCGAAGCGCTGACCTATACGCTGCTGTTCAATACCGCGCCGGTCGCGTTCGGCGCGCTCGGCGTGCC
GATCACGGTGCTCGGCGCGGTCACCTCGCTGCCGCCGACGACGCTCGCCGCGATGGTCGGCCGCCAGCTGCCGTTCTTCG
CGCTGCTGCTGCCGTTCTATGTGGTCGGCGCGTACGGCGGCATGCGTTCGATCGCGCGGCTCTGGCCTGCGCTGCTCGTA
TCGGGCGGCAGCTTCGCGCTCGCGCAGTTCGTCACGTCGAACTATCTCGGCTATCAGCTGACGGACGTGCTGTCGTCGCT
CACGTCGCTGATCGTCACGATCGGCTTCCTGCAGATGTGGAAGCCGCAGCCCGATCCACAGTTCTCGCTCGCGCGCGGCG
CGGGCGCGGGCACGGCCACGGGCGTGGTCACGGCCGGCAGCGGGATGCGCGCCGGATTCGGCGGCTGGCTGCCGTGGATC
GTCGTGTCGATCGTCGTGATCGTGTGGGTGCATGCGAACATCGCGGCGATCGGCGACGTGAAGATCAAGTGGCCCGGGCT
GCACAATGCAGTGTTCGTGTCGCTGTACCAGAAGCCGTATGCGGCGATCTGGGATTTCCAGCCGCTCGGCACCGGCACCG
CGATCCTCGTGTCGGCGATCATCACGGCTGCGCTCACGCGCACGGGCGTCGGCGCGTTCTTCGAGTGCGTGGTGAAAACG
TGGCGGCAGACGTGGATCGCGATCGTCACGGTGATGATGATCGTCGGGCTCGCGTACCTGCTCAACTACTCGGGCATCAG
CTATACGCTCGGCACCGGCGTCGCATCGACGGGCGCGCTGTTCCCGCTCGTATCGGCGTCGCTCGGCTGGATCGCGGTGT
TCCTGTCGGGCAGCGATACGTCGGGCAATGCGCTGTTCGGCAACCTGCAGGTCGTCGCCGCGCGGCAGCTCGGCCTCGAT
CCGGTGCTGATGGCCGCGACCAACTCGTCGGGCGGCGTGATGGGCAAGATGATTTCGCCGCAGAATATCGCGACGGGCGT
GTCGACGACCGATCTGAAGGGGCGCGAAGGGATCGTCTTCGCGCGCACGTTCTGGCACAGCGTCGTGCTGACGCTGCTGC
TCGGCGTACTCGTGTTCCTGCAGCAGCACGTGCTCACCTGGATGATTCCGGCGCTGCCGAAGTGA

Upstream 100 bases:

>100_bases
CGTGCCTCCTAACCTCTTTTAAGCGACCGATCGGTTGGCGACGCAGGCCGTTGCATGCGCAAGCGGCCGATCGGCTCGTC
GTCCATCCAGAGGAGACACG

Downstream 100 bases:

>100_bases
GCGCTGCTACGGCGCGGCGGCGCAAGCTTTTTGGAAACTGAAAACTGTTGACAATGTGTCGGGCTAAGGGTATACAGGGA
TCATTCGCCGATATGGCGCC

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MNPTVALPPGIVFAQPLTPVAGSLLLSFLVAVIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPTTLAAMVGRQLPFFALLLPFYVVGAYGGMRSIARLWPALLV
SGGSFALAQFVTSNYLGYQLTDVLSSLTSLIVTIGFLQMWKPQPDPQFSLARGAGAGTATGVVTAGSGMRAGFGGWLPWI
VVSIVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYQKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKT
WRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLD
PVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGREGIVFARTFWHSVVLTLLLGVLVFLQQHVLTWMIPALPK

Sequences:

>Translated_554_residues
MNPTVALPPGIVFAQPLTPVAGSLLLSFLVAVIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPTTLAAMVGRQLPFFALLLPFYVVGAYGGMRSIARLWPALLV
SGGSFALAQFVTSNYLGYQLTDVLSSLTSLIVTIGFLQMWKPQPDPQFSLARGAGAGTATGVVTAGSGMRAGFGGWLPWI
VVSIVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYQKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKT
WRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLD
PVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGREGIVFARTFWHSVVLTLLLGVLVFLQQHVLTWMIPALPK
>Mature_554_residues
MNPTVALPPGIVFAQPLTPVAGSLLLSFLVAVIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPTTLAAMVGRQLPFFALLLPFYVVGAYGGMRSIARLWPALLV
SGGSFALAQFVTSNYLGYQLTDVLSSLTSLIVTIGFLQMWKPQPDPQFSLARGAGAGTATGVVTAGSGMRAGFGGWLPWI
VVSIVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYQKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKT
WRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLD
PVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGREGIVFARTFWHSVVLTLLLGVLVFLQQHVLTWMIPALPK

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=556, Percent_Identity=40.1079136690648, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1790031, Length=546, Percent_Identity=39.3772893772894, Blast_Score=321, Evalue=9e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58015; Mature: 58015

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTVALPPGIVFAQPLTPVAGSLLLSFLVAVIPIAVALIALGVLRRPAWQASLAGLVAG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTYTLLFNTAPVA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
FGALGVPITVLGAVTSLPPTTLAAMVGRQLPFFALLLPFYVVGAYGGMRSIARLWPALLV
HHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SGGSFALAQFVTSNYLGYQLTDVLSSLTSLIVTIGFLQMWKPQPDPQFSLARGAGAGTAT
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCC
GVVTAGSGMRAGFGGWLPWIVVSIVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYQKPY
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCHHHHHHHHHCCH
AAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKTWRQTWIAIVTVMMIVGLAYL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLD
HHCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCCCC
PVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGREGIVFARTFWHSVVLTLLLGVLVFL
CEEEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
QQHVLTWMIPALPK
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNPTVALPPGIVFAQPLTPVAGSLLLSFLVAVIPIAVALIALGVLRRPAWQASLAGLVAG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTYTLLFNTAPVA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
FGALGVPITVLGAVTSLPPTTLAAMVGRQLPFFALLLPFYVVGAYGGMRSIARLWPALLV
HHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SGGSFALAQFVTSNYLGYQLTDVLSSLTSLIVTIGFLQMWKPQPDPQFSLARGAGAGTAT
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCC
GVVTAGSGMRAGFGGWLPWIVVSIVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYQKPY
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCHHHHHHHHHCCH
AAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKTWRQTWIAIVTVMMIVGLAYL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLD
HHCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCCCC
PVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGREGIVFARTFWHSVVLTLLLGVLVFL
CEEEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
QQHVLTWMIPALPK
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]