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The map label for this gene is gyaR [H]

Identifier: 161526298

GI number: 161526298

Start: 3418501

End: 3419514

Strand: Direct

Name: gyaR [H]

Synonym: Bmul_3129

Alternate gene names: 161526298

Gene position: 3418501-3419514 (Clockwise)

Preceding gene: 161526296

Following gene: 161526301

Centisome position: 99.13

GC content: 65.38

Gene sequence:

>1014_bases
ATGAAAATTGCCATCCTCGACGACTACCAGGACGCCGTCCGCAAGCTGAACTGCTTCGAGATGCTCGCCGACCACGACGT
GAAGGTCTTCAACAACACGGTGCGCGGGCTGGGGCAACTCGCGAGCCGCCTTGCGGAAGTCGAGGCGCTCGTGCTGATTC
GCGAACGCACGCCGATCTCGTCGCAACTGCTCGCCAAATTGCCGAATCTGCGCATGATCAGCCAGACCGGCCGTATTTCG
AGCCATATCGATCTCGACGCGTGTACCGACCGCGGGATCGCGGTGCTCGAAGGCACCGGCTCGCCGATCGCGCCGGCCGA
ACTGACGTGGGCGCTCGTGATGGCCGCGCAGCGCCGCATTCCGCAATACGTCGCGAACCTGAAGCAGGGCGCGTGGCAGC
AGTCGGGGCTGAAGACGTCGGCGCTGCCGCCGAACTTCGGTCTCGGCCAGGTGCTGCGCGGGCAGACGCTCGGCATCTGG
GGTTACGGCAAGATCGGCCGGCTCGTCGCCGGCTACGGCAAGGCGTTCGGAATGAACGTGATGATCTGGGGCCGCGAACA
TTCGCTCGAGGCCGCGCGCGCCGACGGCTACACCGCCGCCGAGAGCCGCGAAGCGCTGTTCGAGCAGAGCGACGTGCTGT
CGCTCCACCTGCGGCTGCACGACGACACGCGCGGAATCGTCAAGCAGGAAGACCTGATGCGGATGAAGCCGACGTCGCTG
CTCGTCAACACGAGCCGCGCGGAACTGCTCGAGGAAAACGCGCTCGTCAACGCGCTGTCGCACAACCGGCCGGGGATGGT
CGCGATCGACGTGTACGAGAGCGAGCCGATCCTGCAGGGCTACAGCCTGCTGCGGATGGAAAACGTGATCTGCACGCCGC
ACATCGGCTACGTCGAGCGCGAAAGCTACGAGCTGTATTTCAGCGCCGCGTTCAAGAACATCCTCGCGTTCGACCAGGGC
GACACGTCGAGCGTCGTCAACCCGGAAGCGCTGCTGCCGGTCCGCAAGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCGGCCGACGTAGCATCATGTCGGCCCCGGCCGCGCGGGACGGGCGCGCCTTGCGCCGCCGCTGCCGGATTCAACGC
GCAACACCACCCCGCTCACC

Downstream 100 bases:

>100_bases
TCGCTCGCCGCGCGCCGCTTCACGCGGCGACGCGGCCGTCCGTCATCGCGCCGACGCGCGCGAGGAAATGTTCGCCGTCG
CGGCGCCCGAGATCGTATGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLDACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVMIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFKNILAFDQG
DTSSVVNPEALLPVRKR

Sequences:

>Translated_337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLDACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVMIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFKNILAFDQG
DTSSVVNPEALLPVRKR
>Mature_337_residues
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPISSQLLAKLPNLRMISQTGRIS
SHIDLDACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVMIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFKNILAFDQG
DTSSVVNPEALLPVRKR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=332, Percent_Identity=27.710843373494, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=31.7647058823529, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=31.7647058823529, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=30.1960784313725, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=30.1960784313725, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=28.7937743190661, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=33.0739299610895, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082289, Length=305, Percent_Identity=29.8360655737705, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=31.0344827586207, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=25.9398496240602, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=333, Percent_Identity=27.3273273273273, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=286, Percent_Identity=27.972027972028, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=25.7246376811594, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=28.4444444444444, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=31.6, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=28.4584980237154, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=27.3648648648649, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=27.1698113207547, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=26.2745098039216, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37303; Mature: 37303

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIS
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
SQLLAKLPNLRMISQTGRISSHIDLDACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHCCHHHCCEE
MIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFKNILAFDQGDTSSVVNPEALLPVRKR
CCEEEEEHHHHHHHHEECCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIS
CEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
SQLLAKLPNLRMISQTGRISSHIDLDACTDRGIAVLEGTGSPIAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHCCHHHCCEE
MIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFKNILAFDQGDTSSVVNPEALLPVRKR
CCEEEEEHHHHHHHHEECCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]