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The map label for this gene is lon [H]

Identifier: 161526213

GI number: 161526213

Start: 3327827

End: 3328450

Strand: Reverse

Name: lon [H]

Synonym: Bmul_3044

Alternate gene names: 161526213

Gene position: 3328450-3327827 (Counterclockwise)

Preceding gene: 161526214

Following gene: 161526212

Centisome position: 96.52

GC content: 69.23

Gene sequence:

>624_bases
ATGCTCGGCACCGCTTATCACTACGTGCCGATGAGTTCGCTGACGGCCGGCTGGATCCTGTCGGGCGCATCGTCGCAATG
GAAGAACGCGAAGCCCGGCAAGGTGTTCGACGCGCTCGTGAACGGCAGCTATGCGAACCCCGTGATCGCCGTCGACGAAA
TCGACAAGGCCGGCGCCGATGCGCAATACGATCCGCTCGGCGCACTCTACGCGCTGCTCGAGCACGACACCGCGCGCGCC
TTCGTCGACGAATTCGCCGAAGTGCCGATCGATGCGGGCAACGTGATCTGGATCGCGACCGCGAACGACGCGCATGCGAT
TCCCGAGCCGCTGCTGAACCGCATGAACGTCTACGAGATCGCGCCGCCCGATGCGGCGGGCGCGCGTCGCATTGCGCAGA
CGATCTACGACGAGATCCGCATGTCGCACGCGTGGGGCCGGCGCTTCCCGGAAACGCTCGGCGATGCCGCGCTCGACGTG
CTGGCCGCGACGCCGCCGCGCACGATGCGCCGCGCGCTGCTGCACGCGTTCGGCGCCGCGCGGCTCGACGGGCGCGACGC
GATCGAGCCGCGCGACATCCGCGCGGACGAAGGCTCGGCGCGGCGCAGGCCGATCGGGTTCTGA

Upstream 100 bases:

>100_bases
GCAACCAGCCTATGCCCGAACCGGCGTAGAGCCCTGCTCCGAAGCCGCGAACATGCGTTGACAGTCGGTACGAGATCATT
TCGCGAAGGCGCTCGCGCAG

Downstream 100 bases:

>100_bases
GCGGCGCGCGGCGGCGCGCGCCGCGCCGCGTGTGCGATGCGTAACAGTCGTGACGAGACGTACATCGCGATCGGCAGACG
GGTGAACCGGGACGTACAAT

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGADAQYDPLGALYALLEHDTARA
FVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIAPPDAAGARRIAQTIYDEIRMSHAWGRRFPETLGDAALDV
LAATPPRTMRRALLHAFGAARLDGRDAIEPRDIRADEGSARRRPIGF

Sequences:

>Translated_207_residues
MLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGADAQYDPLGALYALLEHDTARA
FVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIAPPDAAGARRIAQTIYDEIRMSHAWGRRFPETLGDAALDV
LAATPPRTMRRALLHAFGAARLDGRDAIEPRDIRADEGSARRRPIGF
>Mature_207_residues
MLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGADAQYDPLGALYALLEHDTARA
FVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIAPPDAAGARRIAQTIYDEIRMSHAWGRRFPETLGDAALDV
LAATPPRTMRRALLHAFGAARLDGRDAIEPRDIRADEGSARRRPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=120, Percent_Identity=34.1666666666667, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI31377667, Length=119, Percent_Identity=31.0924369747899, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786643, Length=102, Percent_Identity=34.3137254901961, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17505831, Length=103, Percent_Identity=34.9514563106796, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556486, Length=120, Percent_Identity=28.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319449, Length=115, Percent_Identity=36.5217391304348, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221513036, Length=102, Percent_Identity=37.2549019607843, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24666867, Length=102, Percent_Identity=37.2549019607843, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR001984
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 22466; Mature: 22466

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGAD
CCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC
AQYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEE
APPDAAGARRIAQTIYDEIRMSHAWGRRFPETLGDAALDVLAATPPRTMRRALLHAFGAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RLDGRDAIEPRDIRADEGSARRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGAD
CCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCC
AQYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEE
APPDAAGARRIAQTIYDEIRMSHAWGRRFPETLGDAALDVLAATPPRTMRRALLHAFGAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RLDGRDAIEPRDIRADEGSARRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA