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The map label for this gene is lhgO [H]

Identifier: 161526212

GI number: 161526212

Start: 3326577

End: 3327686

Strand: Reverse

Name: lhgO [H]

Synonym: Bmul_3043

Alternate gene names: 161526212

Gene position: 3327686-3326577 (Counterclockwise)

Preceding gene: 161526213

Following gene: 161526211

Centisome position: 96.5

GC content: 71.17

Gene sequence:

>1110_bases
ATGGAGCAGATGGATTGTGTAGTGATCGGCGCGGGCGTCGTGGGGCTGGCGATCGCGCGGGAGCTCGCCGCGCGCGGACG
AGAGACGCTCGTGCTCGAGGCGGCCGACGCGATCGGCACCGGCACGAGCTCGCGCAACAGCGAGGTGATCCACGCGGGGC
TCTACTATCCGCGCGGATCGCTGAAGGCGCTGTCGTGCGTGCGCGGGCGCGACCTGCTGTACGACTTCTGCGAGACGCAT
CACGTGCCGCACCGGCGCGTCGGCAAGCTGCTCGTCGCGACGACCGCCTCGCAGGTGAAACAGCTGAAGGCGATCGCCGC
GCGTGCGGAGGAGAACGGCGTGCTCGATCTGCTGCCGCTCACGCGCGCCGAAGCGCAGGCGCTCGAACCCGCGCTCGAAT
GCGTGGAGGCGCTGTTCTCGCCGTCCACCGGCATCGTCGACAGCCATCAGCTGATGCTCGCGCTGCTCGGCGACGCGCAA
CGCGACGGCGCCGTATGCGCGCTGAAGTCGCCGGTCGAATCGATCGACGTGCTGCGCGGCGGCCGCTTCGTCGTGCGTAC
CGGCGGCGACGCGCCGACCGAGATCGAAGCCGCGTGCGTGATCAACAGCGCGGGCCTCGGCGCGCAGGCGCTCGCGCGCC
GCACGCGCGGACTCGATCCGCGCTGGGTGCCGCCGCTCTATCTCGCGCGCGGCAACTACTTCAGCTTGTCCGGTCGCGCG
CCGTTCTCGCATCTCGTCTATCCGATGCCGGATCGCGCCGGCCTCGGCATTCACTTGACGCTCGATCTCGCCGGGCAGGC
GCGCTTCGGTCCGGATGTCGAATGGATCGACGCGCTGCGGTACGAAGTCGATCCGGCGCGCGCGGGCGCGTTCTACGCGT
CGATCCGCGCGTACTGGCCCGAGCTGCCCGACGGCGCGCTGCAGCCCGCTTACGCAGGCATCCGGCCGAAGGTCGCGGGG
CCCGGCGAGCCGCCTGCCGACTTCATCGTGCAGGGCGCCGCGCAGCACGGCGTGCGCGGGCTCGTGAATCTGTTCGGCAT
CGAATCGCCGGGGCTCACGGCCTCGCTTGCGCTCGCGCAGCGAGTCGGCGAGATGGCCGCATACGGCTAG

Upstream 100 bases:

>100_bases
GTAACAGTCGTGACGAGACGTACATCGCGATCGGCAGACGGGTGAACCGGGACGTACAATTCCGCTGTCTCCCCTCTACG
CGCGAGCGACGCGACAAGTC

Downstream 100 bases:

>100_bases
CGGCCGTTCGTGCGGCCCCGCGAACGGCGGCCGGCGTGCATCGCAGGCGCGCCGTGTGAAATTCATTATTTCCGGCATTT
CGGGACGCACGTTTCGGCGC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MEQMDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKALSCVRGRDLLYDFCETH
HVPHRRVGKLLVATTASQVKQLKAIAARAEENGVLDLLPLTRAEAQALEPALECVEALFSPSTGIVDSHQLMLALLGDAQ
RDGAVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLVYPMPDRAGLGIHLTLDLAGQARFGPDVEWIDALRYEVDPARAGAFYASIRAYWPELPDGALQPAYAGIRPKVAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGEMAAYG

Sequences:

>Translated_369_residues
MEQMDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKALSCVRGRDLLYDFCETH
HVPHRRVGKLLVATTASQVKQLKAIAARAEENGVLDLLPLTRAEAQALEPALECVEALFSPSTGIVDSHQLMLALLGDAQ
RDGAVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLVYPMPDRAGLGIHLTLDLAGQARFGPDVEWIDALRYEVDPARAGAFYASIRAYWPELPDGALQPAYAGIRPKVAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGEMAAYG
>Mature_369_residues
MEQMDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKALSCVRGRDLLYDFCETH
HVPHRRVGKLLVATTASQVKQLKAIAARAEENGVLDLLPLTRAEAQALEPALECVEALFSPSTGIVDSHQLMLALLGDAQ
RDGAVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLVYPMPDRAGLGIHLTLDLAGQARFGPDVEWIDALRYEVDPARAGAFYASIRAYWPELPDGALQPAYAGIRPKVAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGEMAAYG

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=258, Percent_Identity=31.3953488372093, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI87082148, Length=339, Percent_Identity=29.2035398230088, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17565764, Length=282, Percent_Identity=34.7517730496454, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24585081, Length=397, Percent_Identity=30.2267002518892, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39059; Mature: 39059

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQMDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGS
CCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKALSCVRGRDLLYDFCETHHVPHRRVGKLLVATTASQVKQLKAIAARAEENGVLDLLPL
HHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TRAEAQALEPALECVEALFSPSTGIVDSHQLMLALLGDAQRDGAVCALKSPVESIDVLRG
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCC
GRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
CEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCC
PFSHLVYPMPDRAGLGIHLTLDLAGQARFGPDVEWIDALRYEVDPARAGAFYASIRAYWP
CHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ELPDGALQPAYAGIRPKVAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RVGEMAAYG
HHHHHHCCC
>Mature Secondary Structure
MEQMDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGS
CCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKALSCVRGRDLLYDFCETHHVPHRRVGKLLVATTASQVKQLKAIAARAEENGVLDLLPL
HHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TRAEAQALEPALECVEALFSPSTGIVDSHQLMLALLGDAQRDGAVCALKSPVESIDVLRG
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCC
GRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
CEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCC
PFSHLVYPMPDRAGLGIHLTLDLAGQARFGPDVEWIDALRYEVDPARAGAFYASIRAYWP
CHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ELPDGALQPAYAGIRPKVAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RVGEMAAYG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]