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The map label for this gene is proC [H]

Identifier: 161525825

GI number: 161525825

Start: 2898922

End: 2899734

Strand: Direct

Name: proC [H]

Synonym: Bmul_2656

Alternate gene names: 161525825

Gene position: 2898922-2899734 (Clockwise)

Preceding gene: 161525824

Following gene: 161525832

Centisome position: 84.06

GC content: 72.32

Gene sequence:

>813_bases
ATGAAAATCGCATTCATCGGCGGCGGCAACATGGCCGCGGCCCTGATCGGCGGCCTCGTCAAGCGCGGCGTCGCCGCGGA
CGGCCTCTACGCCATCGACGTCAACGAAGACGTCCGCGCGCGCGCCGCGCAGCAGTTCGGCATCCGCACCGGCGCCGCGA
TCGACGCCGCACTCGGCGACTACGACGCGATCGTGCTCGCGGTCAAGCCGCAGGTGCTGAAGGACGTCGCGCAGGCGCTC
GCGCCGCATCTGCGCGCGCAGCTCGTGATCAGCATCGCGGCCGGCATCCGGGGCGCGGATCTGTCGCGCTGGCTCGGCGG
CTACGCGCGCGTCGTGCGCACGATGCCGAACACGCCCGCGCTCGTCGGCATGGGCGTGACGGGCCTCGCCGCCCTGCCCG
GCGTCGATGCGGCCGGCCGCGAACTGGCTTCGAACGTGCTCGGCGCGGTCGGCGAGATCGTCTGGTTCGACGACGAATCG
CGCCTCGACACCGTCACCGCGATCTCGGGCAGCGGGCCCGCATACGTGTTCTATTTCATCGAAGCGCTGCAGGAAGCGGC
GCGCCGTCTCGGGATGAACGACGAACAGGGCCGCGCGCTCGCGGTCGCGACGTTTACGGGCGCTGCGCAGCTCGCCGCGC
AATCAGGCGAGCCGGCCGGCGTGCTGCGCGAGCGCGTGACGTCGAAGGGCGGCACGACGGCCGCCGCGCTCGCGTCGTTC
GACGCGCAGGGCGTGAAGGAAGCGATCGTGCGCGGCGTGCTCGCGGCCGACGCACGCGCGAAGGAAATGGGCGACGAACT
CGGCCGCGCCTGA

Upstream 100 bases:

>100_bases
GCGACGATCGTGCGCGTCGGCACCGCCATCTTCGGCGCGCGCGACTATTCGCGCTGAACGCCGCGCCCTATCCCTTCACT
CACTCGCTCAATCCGACATC

Downstream 100 bases:

>100_bases
GCGGCTCGACGCTTCGTCCTGCACGAGGGTGGACTTGCGCAGCAGACCGCGCACGCCATCATCCGGCAGCAGCAACAAAA
AAGCGGCCTCGGCCGCTTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIAFIGGGNMAAALIGGLVKRGVAADGLYAIDVNEDVRARAAQQFGIRTGAAIDAALGDYDAIVLAVKPQVLKDVAQAL
APHLRAQLVISIAAGIRGADLSRWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASNVLGAVGEIVWFDDES
RLDTVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALASF
DAQGVKEAIVRGVLAADARAKEMGDELGRA

Sequences:

>Translated_270_residues
MKIAFIGGGNMAAALIGGLVKRGVAADGLYAIDVNEDVRARAAQQFGIRTGAAIDAALGDYDAIVLAVKPQVLKDVAQAL
APHLRAQLVISIAAGIRGADLSRWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASNVLGAVGEIVWFDDES
RLDTVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALASF
DAQGVKEAIVRGVLAADARAKEMGDELGRA
>Mature_270_residues
MKIAFIGGGNMAAALIGGLVKRGVAADGLYAIDVNEDVRARAAQQFGIRTGAAIDAALGDYDAIVLAVKPQVLKDVAQAL
APHLRAQLVISIAAGIRGADLSRWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASNVLGAVGEIVWFDDES
RLDTVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALASF
DAQGVKEAIVRGVLAADARAKEMGDELGRA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=32.1969696969697, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=28.996282527881, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=28.996282527881, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=27.1375464684015, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=33.9483394833948, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.8289962825279, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=29.7872340425532, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=28.6713286713287, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=35.6060606060606, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=30.2158273381295, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=38.4615384615385, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27585; Mature: 27585

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLVKRGVAADGLYAIDVNEDVRARAAQQFGIRTGAAIDAALGD
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCC
YDAIVLAVKPQVLKDVAQALAPHLRAQLVISIAAGIRGADLSRWLGGYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLAALPGVDAAGRELASNVLGAVGEIVWFDDESRLDTVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCEEEEECCCCCCHHHHHH
EALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQGVKEAIVRGVLAADARAKEMGDELGRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLVKRGVAADGLYAIDVNEDVRARAAQQFGIRTGAAIDAALGD
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCC
YDAIVLAVKPQVLKDVAQALAPHLRAQLVISIAAGIRGADLSRWLGGYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLAALPGVDAAGRELASNVLGAVGEIVWFDDESRLDTVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCEEEEECCCCCCHHHHHH
EALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPAGVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQGVKEAIVRGVLAADARAKEMGDELGRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]