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The map label for this gene is panB [H]

Identifier: 161525799

GI number: 161525799

Start: 2864961

End: 2865776

Strand: Direct

Name: panB [H]

Synonym: Bmul_2630

Alternate gene names: 161525799

Gene position: 2864961-2865776 (Clockwise)

Preceding gene: 161525798

Following gene: 161525805

Centisome position: 83.08

GC content: 68.63

Gene sequence:

>816_bases
ATGACCTATCTCCAGGAATCGAGCCGGCCTGCCGTGACGGTGCCGAAGCTGCAGGCGATGCGCGACGCCGGCGAGAAGAT
CGCGATGCTCACGTGCTACGACGCGAGCTTCGCCGCATTGCTCGACCGCGCGGGCACCGACGTGCTGCTGATCGGCGATT
CGCTCGGCAACGTGCTGCAGGGCCACGCGACGACGCTGCCCGTGTCGCTCGACGACATCGCGTATCACACCGCATGCGTC
GCGCGCGCGCAGCCGCGCGCGCTCGTCGTCGCCGATCTGCCGTTCGGCACCTACGGCACGCCGGCCGATGCGTTCGCGAA
CGCGGTCGAACTGATGCGCGCAGGCGCGCAGATGGTCAAGCTCGAAGGCGGCGAATGGCTCGCCGAGACGATCCGCTTCC
TCGTCGAGCGCTCGGTGCCGGTATGCGCGCACCTCGGCCTCACGCCGCAGTCGGTGCACGCGTTCGGCGGCTTCAAGGTG
CAAGGCAAGACCGAAGCCGGCGCCGCGCAGCTGCTGCGCGACGCGCGCGCGATCGAGGCGGCCGGCGCACAGCTCGTCGT
GCTCGAAGCGGTGCCGACGCTCGTCGCCTCCGAAGTCACGCACATGCTGAAGATTCCGACGATCGGCATCGGCGCGGGCG
CCGACTGCTCGGGGCAAGTGCTCGTGCTGCACGACATGCTCGGGATCTACCCCGGCAAGCGGCCGCGTTTCGTGAAGGAT
TTCATGCAGGGGCAGCCGAACATCGAGGCGGCGGTCGATGCGTATGTGAAGGCGGTGAAGGACGGCTCGTTCCCCGGGCC
CGAACATTCGTTCTGA

Upstream 100 bases:

>100_bases
GAAACGATGCGCGGCCGCAAGGAATTCTTCGTCAAGGGCGAGACGACGCGCTGACGCGCGCCTCGCCCGTCGTTTTTCAC
TCATCGAACCGGATTTCCCC

Downstream 100 bases:

>100_bases
GTATCCATCGCGGCGCGCCCGCGCGATCCGTCGACAAACGAAAGCGCGACGTCCGTTACCGGGCGTCGCGCTTTTTTGTT
TGCAGCGTGAGCGAAGGCGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQGHATTLPVSLDDIAYHTACV
ARAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVKLEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKV
QGKTEAGAAQLLRDARAIEAAGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKD
FMQGQPNIEAAVDAYVKAVKDGSFPGPEHSF

Sequences:

>Translated_271_residues
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQGHATTLPVSLDDIAYHTACV
ARAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVKLEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKV
QGKTEAGAAQLLRDARAIEAAGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKD
FMQGQPNIEAAVDAYVKAVKDGSFPGPEHSF
>Mature_270_residues
TYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQGHATTLPVSLDDIAYHTACVA
RAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVKLEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKVQ
GKTEAGAAQLLRDARAIEAAGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKDF
MQGQPNIEAAVDAYVKAVKDGSFPGPEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=259, Percent_Identity=55.2123552123552, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6319653, Length=278, Percent_Identity=35.9712230215827, Blast_Score=179, Evalue=5e-46,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28596; Mature: 28465

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQ
CCCCCCCCCCCEECHHHHHHHCCCCEEEEEEEECCHHHHHHHHCCCCEEEECCCHHHHHH
GHATTLPVSLDDIAYHTACVARAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVK
CCCEEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAIEA
ECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
AGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKD
CCCEEEEEHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHH
FMQGQPNIEAAVDAYVKAVKDGSFPGPEHSF
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFAALLDRAGTDVLLIGDSLGNVLQ
CCCCCCCCCCEECHHHHHHHCCCCEEEEEEEECCHHHHHHHHCCCCEEEECCCHHHHHH
GHATTLPVSLDDIAYHTACVARAQPRALVVADLPFGTYGTPADAFANAVELMRAGAQMVK
CCCEEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLAETIRFLVERSVPVCAHLGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAIEA
ECCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
AGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGADCSGQVLVLHDMLGIYPGKRPRFVKD
CCCEEEEEHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHH
FMQGQPNIEAAVDAYVKAVKDGSFPGPEHSF
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA