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The map label for this gene is rmlA1 [H]

Identifier: 161525766

GI number: 161525766

Start: 2819316

End: 2820209

Strand: Direct

Name: rmlA1 [H]

Synonym: Bmul_2597

Alternate gene names: 161525766

Gene position: 2819316-2820209 (Clockwise)

Preceding gene: 161525765

Following gene: 161525767

Centisome position: 81.76

GC content: 61.3

Gene sequence:

>894_bases
ATGGCACGCAAAGGCATCATTCTCGCGGGCGGTTCCGGCACGCGGCTCTATCCGATCACACAGGCCGTATCGAAGCAACT
GCTGCCCGTGTACGACAAGCCGATGATCTACTATCCGCTATCCACGCTGATGATCGCGGGCATTCGCGACGTCCTGATCA
TCTCGACACCGCAGGACACGCCGCGCTTCGAATCGATGCTCGGCGACGGCAGTCAGTGGGGGATGAACATTCAGTACGCG
GTGCAGCCGTCGCCCGACGGTCTCGCGCAGGCGTTCATCATCGGCAAGGACTTCGTCGGCAACGATCCGTCGGCGTTGAT
TCTCGGCGACAACATCTTCTACGGCCACGATCTCGCCAAGCAGCTCGAGCACGCCAACGCGCAGGAACATGGCGCGACCG
TGTTCGCCTATCACGTGCACGATCCCGAGCGGTATGGCGTCGTGGAGTTCGACAAGGACTTTCGCGCGCTGTCGATCGAA
GAGAAGCCGGCGAAGCCGCGTTCGCACTATGCGGTCACGGGCCTGTACTTCTACGACAACCGTGTGTGCGACATCGCGGC
CGACATCAAGCCGTCCGCGCGTGGCGAGCTCGAGATTACCGACGTCAATTCGCGGTATTTGCAGGACGGCACGCTGAACG
TCGAGATCATGGGCCGCGGCTACGCCTGGCTCGACACCGGCACGCACGATTCGTTGATCGAAGCGGCGAGCTTCATCGCG
ACGCTGCAGAAGCGGCAAGGGCTGGTGGTCGCGTGCCCCGAGGAAATCGCATACCGCCGCCAGTGGATCGACGCGGAACA
AGTGCAGAAATTGGCGCAGCCGCTGGCGAAGAACGGCTACGGCAAATATCTGCTGAACATTCTTACGGATCAGGTTGCAT
GGCCATCACGGTAA

Upstream 100 bases:

>100_bases
GGTATCTCGACAACCAGCAGTGGGTCGACGAAGTCGCATCGGGCGAGTACCGCAAGTGGGTCGAAACCAACTACGCGCAG
CGCGCGTAAGGGTGGCAGAG

Downstream 100 bases:

>100_bases
CTGCTACGGCACTGCCCGAAGTCAAAATCATCGAGCCGAAGGTATTCGGCGATGCGCGCGGCTACTTCTACGAAAGCTTC
AACGGGCGCGAATTCGCGGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MARKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYA
VQPSPDGLAQAFIIGKDFVGNDPSALILGDNIFYGHDLAKQLEHANAQEHGATVFAYHVHDPERYGVVEFDKDFRALSIE
EKPAKPRSHYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLQDGTLNVEIMGRGYAWLDTGTHDSLIEAASFIA
TLQKRQGLVVACPEEIAYRRQWIDAEQVQKLAQPLAKNGYGKYLLNILTDQVAWPSR

Sequences:

>Translated_297_residues
MARKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYA
VQPSPDGLAQAFIIGKDFVGNDPSALILGDNIFYGHDLAKQLEHANAQEHGATVFAYHVHDPERYGVVEFDKDFRALSIE
EKPAKPRSHYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLQDGTLNVEIMGRGYAWLDTGTHDSLIEAASFIA
TLQKRQGLVVACPEEIAYRRQWIDAEQVQKLAQPLAKNGYGKYLLNILTDQVAWPSR
>Mature_296_residues
ARKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDTPRFESMLGDGSQWGMNIQYAV
QPSPDGLAQAFIIGKDFVGNDPSALILGDNIFYGHDLAKQLEHANAQEHGATVFAYHVHDPERYGVVEFDKDFRALSIEE
KPAKPRSHYAVTGLYFYDNRVCDIAADIKPSARGELEITDVNSRYLQDGTLNVEIMGRGYAWLDTGTHDSLIEAASFIAT
LQKRQGLVVACPEEIAYRRQWIDAEQVQKLAQPLAKNGYGKYLLNILTDQVAWPSR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=73.9583333333333, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.2105263157895, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787488, Length=248, Percent_Identity=25.4032258064516, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=25.5208333333333, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=24.8995983935743, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=24.8995983935743, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33039; Mature: 32908

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGSQWGMNIQYAVQPSPDGLAQAFIIGKDFVGNDPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECHHHHH
QLEHANAQEHGATVFAYHVHDPERYGVVEFDKDFRALSIEEKPAKPRSHYAVTGLYFYDN
HHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECC
RVCDIAADIKPSARGELEITDVNSRYLQDGTLNVEIMGRGYAWLDTGTHDSLIEAASFIA
EEEEEEECCCCCCCCEEEEEECCCCEECCCEEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQKRQGLVVACPEEIAYRRQWIDAEQVQKLAQPLAKNGYGKYLLNILTDQVAWPSR
HHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLSTLMIAGIRDVLIISTPQDT
CCCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFESMLGDGSQWGMNIQYAVQPSPDGLAQAFIIGKDFVGNDPSALILGDNIFYGHDLAK
HHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECHHHHH
QLEHANAQEHGATVFAYHVHDPERYGVVEFDKDFRALSIEEKPAKPRSHYAVTGLYFYDN
HHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECC
RVCDIAADIKPSARGELEITDVNSRYLQDGTLNVEIMGRGYAWLDTGTHDSLIEAASFIA
EEEEEEECCCCCCCCEEEEEECCCCEECCCEEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQKRQGLVVACPEEIAYRRQWIDAEQVQKLAQPLAKNGYGKYLLNILTDQVAWPSR
HHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]