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The map label for this gene is pcaK [H]

Identifier: 161525733

GI number: 161525733

Start: 2792091

End: 2793443

Strand: Reverse

Name: pcaK [H]

Synonym: Bmul_2564

Alternate gene names: 161525733

Gene position: 2793443-2792091 (Counterclockwise)

Preceding gene: 161525734

Following gene: 161525732

Centisome position: 81.01

GC content: 70.29

Gene sequence:

>1353_bases
GTGAGCGCCGCGGCCGAGGCGCGTACGCTCGAAGTCGAGCGCGTGATCGACGATACGCATCGCCCGGGCTTTCACTGGAT
GCTGCTCGTGCTGTGCGGGCTGTGCCTCGTGATCGACGGCTTCGATGCGCAGGCGATGGGCTACGTCGCGCCGAGCGTGA
TCGCCGAATGGCACGTGCCGAAGCAGGCGCTCGGGCCCGTGTTCAGCGCGAGCCTGTTCGGGATGCTGCTCGGCGCGCTC
GCGCTGTCGGTGCTGGCCGACCGGATCGGCCGCCGGCCGGTGCTGATCGGCGCGACGCTGTTCTTCGCGTTGACGATGCT
CGCGACGCAGTTCGCGAGTTCGATCCCGGTGCTGATGGCGCTGCGCTTCGTCACCGGTCTCGGCCTCGGCTGCATCATGC
CGAACGCGATGGCGCTCGTCGGCGAGTTCAGCCCGAGCGCGCATCGCGTGAAGCGGATGATGATCGTGTCGTGCGGCTTC
ACGCTCGGCGCGGCGATCGGCGGCTTCATCAGCGCCGCGCTGATTCCGGCGCTCGGCTGGCGCGCCGTGTTTTTCGTCGG
CGGCGCGGTGCCGCTCGTGCTCGCGATCGCGATGGCCGCGCGGCTGCCCGAATCGCTGCAGTTTCTCGTGCTGAAAGGGC
GCGACGCGCAGGCGCGCGACTGGCTCGCCGGCTTCGCGCCGCACGCCGGCATCGACGCGAGCACGCGGCTCGTCGTGCGC
GAGCGTGCGACGACGGGCGCGCCGGTCGCCGAATTGTTCCGCGACGGCCGCCTGCCGGTCACGCTGCTGCTGTGGGCGAT
CAGCTTCATGAACCTGATCGATCTGTACTTCCTCTCGAACTGGCTGCCGACCGTGATGCGCGACGCCGGCTATTCGCCGG
GCACCGCGGTGATCGTCGGCACGGTGCTGCAAACGGGCGGCGTGATGGGCACGCTGTCGCTCGGCTGGTTCATCGAACGC
TACGGGTTCGTGCGCGTGCTGTTCGCGTGCTTCGCGTGCGCGGCGGTGTCGGTCGCACTGATCGGCTCGGTCGCGCATGC
GCTGCCGTGGCTGCTGATCGTCGTGTTCGCGGGCGGCTTCTGCGTGGTCGGCGGACAGCCGGCCGTGAACGCGCTCGCGG
GCCAGTATTACCCGACCTCGCTGCGTTCGACCGGCATCGGCTGGAGCCTCGGCATCGGCCGGATCGGCTCCGTGCTCGGG
CCGCTCGTCGGCGGACAACTGATTGCGCTGAACTGGACCAACGGCGCGCTGTTTCATGCGGCCGCGGTACCCGTGCTGTG
CTCGGCGCTGTTCGTGCTCGGGCTGGCCGGCGTGACGCGGCGAAGCGGTGCGCAGGCGCCGCATGCCGCCTGA

Upstream 100 bases:

>100_bases
TCGCGAACCACATCGGCGATCTCGACGTGCTGCGCGAAGCGATGGCGCTCGCGCGCCGCGGCGCGACGCCGCCCGTGCAT
CCGGCCGCCGAGGTGACGCC

Downstream 100 bases:

>100_bases
ATTGATGGAGAAATGAAACGATGACGCTTGACTTGTCGAAACCGGCGACCGCCGGCTACCTGAGCGGTTTCGCGAACGAG
TTCGCGACCGAGGCGCTGCC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSAAAEARTLEVERVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWHVPKQALGPVFSASLFGMLLGAL
ALSVLADRIGRRPVLIGATLFFALTMLATQFASSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPSAHRVKRMMIVSCGF
TLGAAIGGFISAALIPALGWRAVFFVGGAVPLVLAIAMAARLPESLQFLVLKGRDAQARDWLAGFAPHAGIDASTRLVVR
ERATTGAPVAELFRDGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVMGTLSLGWFIER
YGFVRVLFACFACAAVSVALIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWTNGALFHAAAVPVLCSALFVLGLAGVTRRSGAQAPHAA

Sequences:

>Translated_450_residues
MSAAAEARTLEVERVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWHVPKQALGPVFSASLFGMLLGAL
ALSVLADRIGRRPVLIGATLFFALTMLATQFASSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPSAHRVKRMMIVSCGF
TLGAAIGGFISAALIPALGWRAVFFVGGAVPLVLAIAMAARLPESLQFLVLKGRDAQARDWLAGFAPHAGIDASTRLVVR
ERATTGAPVAELFRDGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVMGTLSLGWFIER
YGFVRVLFACFACAAVSVALIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWTNGALFHAAAVPVLCSALFVLGLAGVTRRSGAQAPHAA
>Mature_449_residues
SAAAEARTLEVERVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWHVPKQALGPVFSASLFGMLLGALA
LSVLADRIGRRPVLIGATLFFALTMLATQFASSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPSAHRVKRMMIVSCGFT
LGAAIGGFISAALIPALGWRAVFFVGGAVPLVLAIAMAARLPESLQFLVLKGRDAQARDWLAGFAPHAGIDASTRLVVRE
RATTGAPVAELFRDGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVMGTLSLGWFIERY
GFVRVLFACFACAAVSVALIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGP
LVGGQLIALNWTNGALFHAAAVPVLCSALFVLGLAGVTRRSGAQAPHAA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=420, Percent_Identity=25.4761904761905, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI8923870, Length=374, Percent_Identity=26.2032085561497, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI166064021, Length=353, Percent_Identity=27.4787535410765, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI213021148, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI7662270, Length=226, Percent_Identity=23.4513274336283, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI296080721, Length=210, Percent_Identity=27.6190476190476, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI296080719, Length=210, Percent_Identity=27.6190476190476, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI24497499, Length=210, Percent_Identity=27.6190476190476, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081723, Length=418, Percent_Identity=34.2105263157895, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=21.8274111675127, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082231, Length=427, Percent_Identity=23.6533957845433, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082404, Length=392, Percent_Identity=23.9795918367347, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=25.5154639175258, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788068, Length=440, Percent_Identity=23.8636363636364, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788074, Length=354, Percent_Identity=23.728813559322, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=416, Percent_Identity=23.3173076923077, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71980584, Length=425, Percent_Identity=22.8235294117647, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980582, Length=425, Percent_Identity=22.8235294117647, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565978, Length=277, Percent_Identity=25.6317689530686, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922874, Length=436, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI161077756, Length=473, Percent_Identity=23.6786469344609, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640198, Length=464, Percent_Identity=23.2758620689655, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24640196, Length=464, Percent_Identity=23.2758620689655, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24640200, Length=464, Percent_Identity=23.2758620689655, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47144; Mature: 47013

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAAEARTLEVERVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWHVP
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
KQALGPVFSASLFGMLLGALALSVLADRIGRRPVLIGATLFFALTMLATQFASSIPVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHH
LRFVTGLGLGCIMPNAMALVGEFSPSAHRVKRMMIVSCGFTLGAAIGGFISAALIPALGW
HHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RAVFFVGGAVPLVLAIAMAARLPESLQFLVLKGRDAQARDWLAGFAPHAGIDASTRLVVR
HHHHHHCCHHHHHHHHHHHHHCCHHEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEE
ERATTGAPVAELFRDGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVG
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVLQTGGVMGTLSLGWFIERYGFVRVLFACFACAAVSVALIGSVAHALPWLLIVVFAGGF
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
CVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWTNGALFHA
EEECCCHHHHHHHCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCCHHHHH
AAVPVLCSALFVLGLAGVTRRSGAQAPHAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SAAAEARTLEVERVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWHVP
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
KQALGPVFSASLFGMLLGALALSVLADRIGRRPVLIGATLFFALTMLATQFASSIPVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHH
LRFVTGLGLGCIMPNAMALVGEFSPSAHRVKRMMIVSCGFTLGAAIGGFISAALIPALGW
HHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RAVFFVGGAVPLVLAIAMAARLPESLQFLVLKGRDAQARDWLAGFAPHAGIDASTRLVVR
HHHHHHCCHHHHHHHHHHHHHCCHHEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEE
ERATTGAPVAELFRDGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVG
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVLQTGGVMGTLSLGWFIERYGFVRVLFACFACAAVSVALIGSVAHALPWLLIVVFAGGF
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
CVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWTNGALFHA
EEECCCHHHHHHHCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCCHHHHH
AAVPVLCSALFVLGLAGVTRRSGAQAPHAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]