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The map label for this gene is hmgA [H]

Identifier: 161525732

GI number: 161525732

Start: 2790736

End: 2792070

Strand: Reverse

Name: hmgA [H]

Synonym: Bmul_2563

Alternate gene names: 161525732

Gene position: 2792070-2790736 (Counterclockwise)

Preceding gene: 161525733

Following gene: 161525731

Centisome position: 80.97

GC content: 67.72

Gene sequence:

>1335_bases
ATGACGCTTGACTTGTCGAAACCGGCGACCGCCGGCTACCTGAGCGGTTTCGCGAACGAGTTCGCGACCGAGGCGCTGCC
CGGCGCGCTGCCGCACGGCCGCAATTCGCCGCAGCGCGCACCGTACGGCCTGTATGCGGAGCAACTGTCGGGCACCGCGT
TTACCGCGCCGCGCGGCCATAACCGCCGCTCGTGGCTGTACCGGATCCGGCCGGCCGCCGTGCACCGGCCGTTCGAGCCG
TTCGCGGGCGCGCAGCGCCTCGTGTCGGACTTCGCCGACTCGGCCGACGTGCCGCCGACGCCGCCGAACCAGCTGCGCTG
GAATCCGCTGCCGATGCCGAGCGAGCCGACCGATTTCGTCGAAGGGCTCGTGACGATGGCCGGCAACGGCTCGGCCGCCG
CGATGAGCGGCTGCGCGATCCATCTGTATGCGGCGAACCGTTCGATGCGGGACCGCTTCTTCTACAGCGCGGACGGCGAA
CTGCTGATCGTCCCGCAGCAGGGGCGGCTCTTCATCGCGACCGAATTGGGCCGCCTCGACGTCGAGCCGTTCGAGATCGC
AGTGATTCCGCGCGGCGTGCGCTTCACGGTCGCGCTGCCGGACGGCGATGCGCGCGGCTATATCTGCGAGAACTTCGGCG
CGCTGCTGCGGCTGCCCGATCTCGGCCCGATCGGCTCGAACGGGCTCGCGAATCCGCGCGACTTCCTGACGCCGCAGGCC
GCATACGAAGACCGCGAAGGCGCGTTCGAGCTCGTCGCGAAGCTCAACGGCCGGCTCTGGCGCGCGGACATCGGCCATTC
GCCGCTCGACGTCGTCGCGTGGCACGGCAACTATGCGCCGTACAAATACGACCTGCGCCTGTTCAACACGATCGGCTCGA
TCAGCTTCGACCATCCCGATCCGTCGATCTTCCTCGTGCTGCATTCGCAGACCGATACGCCGGGCGTCGATGCGATCGAC
TTCGTGATCTTCCCGCCGCGCTGGCTCGCGGCCGAGGATACGTTCCGTCCGCCCTGGTTCCACCGCAACGTCGCGAGCGA
GTTCATGGGGCTCGTGCACGGCGCGTACGACGCGAAGGCCGAAGGCTTCGTGCCGGGCGGCGCGAGCCTGCACAACTGCA
TGTCGGGTCACGGCCCGGATGCGGACACGTTCGAGAAGGCGTCGGCGAGCGATACGACGAAGCCGCACAAGGTCGACAAC
ACGATGGCGTTCATGTTCGAAACCCGCACGCTGATCCGGCCGACGCGCTACGCGCTCGACACCGCGCAGCTGCAGGCCAA
CTACTTCGAATGCTGGCAAGGCATCAGGAAACACTTCAATCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
TGCTGTGCTCGGCGCTGTTCGTGCTCGGGCTGGCCGGCGTGACGCGGCGAAGCGGTGCGCAGGCGCCGCATGCCGCCTGA
ATTGATGGAGAAATGAAACG

Downstream 100 bases:

>100_bases
GCGATACCCAAGACTGGCGCGCGACGCTCGACCCGGCCCGCAAGAGCTGGGTCGAGACGGCGAACGATCCCGCCTGCGAT
TTTCCGATCCAGAACCTGCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEP
FAGAQRLVSDFADSADVPPTPPNQLRWNPLPMPSEPTDFVEGLVTMAGNGSAAAMSGCAIHLYAANRSMRDRFFYSADGE
LLIVPQQGRLFIATELGRLDVEPFEIAVIPRGVRFTVALPDGDARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQA
AYEDREGAFELVAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLHSQTDTPGVDAID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDN
TMAFMFETRTLIRPTRYALDTAQLQANYFECWQGIRKHFNPEQR

Sequences:

>Translated_444_residues
MTLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEP
FAGAQRLVSDFADSADVPPTPPNQLRWNPLPMPSEPTDFVEGLVTMAGNGSAAAMSGCAIHLYAANRSMRDRFFYSADGE
LLIVPQQGRLFIATELGRLDVEPFEIAVIPRGVRFTVALPDGDARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQA
AYEDREGAFELVAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLHSQTDTPGVDAID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDN
TMAFMFETRTLIRPTRYALDTAQLQANYFECWQGIRKHFNPEQR
>Mature_443_residues
TLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEPF
AGAQRLVSDFADSADVPPTPPNQLRWNPLPMPSEPTDFVEGLVTMAGNGSAAAMSGCAIHLYAANRSMRDRFFYSADGEL
LIVPQQGRLFIATELGRLDVEPFEIAVIPRGVRFTVALPDGDARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQAA
YEDREGAFELVAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLHSQTDTPGVDAIDF
VIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDNT
MAFMFETRTLIRPTRYALDTAQLQANYFECWQGIRKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=444, Percent_Identity=51.8018018018018, Blast_Score=460, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17507969, Length=432, Percent_Identity=53.4722222222222, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=51.9540229885057, Blast_Score=443, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49009; Mature: 48877

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGH
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFEPFAGAQRLVSDFADSADVPPTPPNQLRWNPLPMPSEPTDFV
CCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EGLVTMAGNGSAAAMSGCAIHLYAANRSMRDRFFYSADGELLIVPQQGRLFIATELGRLD
HHHHHCCCCCCCCEECCCEEEEEECCCCHHHCEEEECCCCEEEEECCCCEEEEEECCCCC
VEPFEIAVIPRGVRFTVALPDGDARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQA
CCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCH
AYEDREGAFELVAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPD
HCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCC
PSIFLVLHSQTDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDNTMAFMFETRTLIRPTRYALD
CCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHHH
TAQLQANYFECWQGIRKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLDLSKPATAGYLSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGH
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFEPFAGAQRLVSDFADSADVPPTPPNQLRWNPLPMPSEPTDFV
CCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EGLVTMAGNGSAAAMSGCAIHLYAANRSMRDRFFYSADGELLIVPQQGRLFIATELGRLD
HHHHHCCCCCCCCEECCCEEEEEECCCCHHHCEEEECCCCEEEEECCCCEEEEEECCCCC
VEPFEIAVIPRGVRFTVALPDGDARGYICENFGALLRLPDLGPIGSNGLANPRDFLTPQA
CCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCH
AYEDREGAFELVAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPD
HCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCC
PSIFLVLHSQTDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDNTMAFMFETRTLIRPTRYALD
CCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHHH
TAQLQANYFECWQGIRKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA