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The map label for this gene is cusR [H]

Identifier: 161525507

GI number: 161525507

Start: 2546328

End: 2547011

Strand: Reverse

Name: cusR [H]

Synonym: Bmul_2337

Alternate gene names: 161525507

Gene position: 2547011-2546328 (Counterclockwise)

Preceding gene: 161525531

Following gene: 161525506

Centisome position: 73.86

GC content: 65.2

Gene sequence:

>684_bases
ATGAAACTGTTGGTGATCGAGGACGAGAACAAGACAGCGGACTACGTGCGCCAGGGCCTCATGGAAGCGGGGTTCGTGGT
GGACCTGGCACGCAATGGCCTGGACGGCCATCACCAGGCCATGAGCGAGACCTACGATCTGGTCATCCTCGACGTCATGC
TGCCGGACGTGGATGGCTGGCGCATCGTTCAATCGCTGCGCGAGGCGGGCAAGCAGGTCCCGGTGCTGTTCCTGACCGCG
CGCGGCGGCGTGGATGACCGCGTGAAGGGCCTGGAACTGGGCGCCGACGACTACCTGGTCAAGCCTTTCGCGTTCTCCGA
GTTGCTCGCGCGCGTGCGCACGCTGCTGCGCCGCGGCAGCGCGCCCAACCACCCCGACCGCATCCAGATCGCCGATCTGC
TGCTCGACCTGCCGCGGCGGCGCGCGACCCGGGCAGGACAGCGCATCAACCTAACCAGCAAGGAGTTCGCCTTGCTCGAA
CTGCTGGCGCGGCGCCAGGGCGAGGTGTTGCCGCGCTCATTGATCGCCTCGCAGGTCTGGGACATGAATTTCGACAGCGA
CAGCAACGTGATCGACGTTGCCATTCGCCGGCTGCGCGCGAAGATCGACGATGCCTTCGATCCCAAGCTCATCCATACGG
TACGGGGCATGGGCTATACGCTGGATGCCCCGGATGCCGACTAA

Upstream 100 bases:

>100_bases
GTTGGTGGAAGATTCACCCGAGTACATTGATTCAGAAGTCAGTCGTGCAGGGTGAGCAAGCAGCTGCGCGAGCGTTCATG
GCGTGAGCCAGGGAAAAGCG

Downstream 100 bases:

>100_bases
GGCCCTGCGCATCCGTCGCCCGGCATCGCTCGCGCTGCGGGTCACGGCCCTGGTCGGCATTGCGACGACGCTGGTGTTCC
TGGCCTTCAGTTGGCTCATC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKLLVIEDENKTADYVRQGLMEAGFVVDLARNGLDGHHQAMSETYDLVILDVMLPDVDGWRIVQSLREAGKQVPVLFLTA
RGGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSAPNHPDRIQIADLLLDLPRRRATRAGQRINLTSKEFALLE
LLARRQGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDAFDPKLIHTVRGMGYTLDAPDAD

Sequences:

>Translated_227_residues
MKLLVIEDENKTADYVRQGLMEAGFVVDLARNGLDGHHQAMSETYDLVILDVMLPDVDGWRIVQSLREAGKQVPVLFLTA
RGGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSAPNHPDRIQIADLLLDLPRRRATRAGQRINLTSKEFALLE
LLARRQGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDAFDPKLIHTVRGMGYTLDAPDAD
>Mature_227_residues
MKLLVIEDENKTADYVRQGLMEAGFVVDLARNGLDGHHQAMSETYDLVILDVMLPDVDGWRIVQSLREAGKQVPVLFLTA
RGGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSAPNHPDRIQIADLLLDLPRRRATRAGQRINLTSKEFALLE
LLARRQGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDAFDPKLIHTVRGMGYTLDAPDAD

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=68.5840707964602, Blast_Score=323, Evalue=7e-90,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=56.5022421524664, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=44.3946188340807, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=36.3636363636364, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=40, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=35.6223175965665, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.0909090909091, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.8181818181818, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=33.1858407079646, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25470; Mature: 25470

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVIEDENKTADYVRQGLMEAGFVVDLARNGLDGHHQAMSETYDLVILDVMLPDVDGW
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCCHH
RIVQSLREAGKQVPVLFLTARGGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGS
HHHHHHHHCCCCCCEEEEEECCCCCHHHCCEEECCCCCEECHHHHHHHHHHHHHHHHCCC
APNHPDRIQIADLLLDLPRRRATRAGQRINLTSKEFALLELLARRQGEVLPRSLIASQVW
CCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDAFDPKLIHTVRGMGYTLDAPDAD
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MKLLVIEDENKTADYVRQGLMEAGFVVDLARNGLDGHHQAMSETYDLVILDVMLPDVDGW
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCCHH
RIVQSLREAGKQVPVLFLTARGGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGS
HHHHHHHHCCCCCCEEEEEECCCCCHHHCCEEECCCCCEECHHHHHHHHHHHHHHHHCCC
APNHPDRIQIADLLLDLPRRRATRAGQRINLTSKEFALLELLARRQGEVLPRSLIASQVW
CCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDAFDPKLIHTVRGMGYTLDAPDAD
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]