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The map label for this gene is cusS [H]

Identifier: 161525506

GI number: 161525506

Start: 2544917

End: 2546338

Strand: Reverse

Name: cusS [H]

Synonym: Bmul_2336

Alternate gene names: 161525506

Gene position: 2546338-2544917 (Counterclockwise)

Preceding gene: 161525507

Following gene: 161525495

Centisome position: 73.84

GC content: 63.01

Gene sequence:

>1422_bases
ATGCCGACTAAGGCCCTGCGCATCCGTCGCCCGGCATCGCTCGCGCTGCGGGTCACGGCCCTGGTCGGCATTGCGACGAC
GCTGGTGTTCCTGGCCTTCAGTTGGCTCATCGTCCGCTCGCTGGAGCACCACTTCGCCGAGCAGGATGCCGGGGAACTCC
GGGCTGTGGCCGATGCCGTCGTCAAGCCGCTGCGCGACCCAGGTACGAGCACCGACGATGCGCTGCTGCGCCGCCGGCTC
GCCGGCGCAGTCACGGGCCATCACGGGGTGTTCTATTACGTCGCCGACGCCGCAGGAACCACGGTATATGCGGGCGAAGG
CCCCGCACTGTCGTCCCTCGTCGCAAGCAAACGTCCCGCCGAGGCGATCAATGCCCGCGAGCTGGCGAGCTGGCAGGAGC
AAGGGAAGTCCTATCGTGGCGCGGTGCTTCGCGTGCAGGGCGACCCAAGCCGGAACATACGCCCCTATACCGTCGCCGTT
GCGATGGACATCGATTTCCATCTCGCGTTTCTCGAAGACTTCAAGCGCATGCTGTGGTTGGCCACATGCGTTGTGCTGTG
CATTGCGCTGCTGGTCGCCTGGCTGGCCGTCCAATGGGGGCACCGGCCCATTCGCAAGGTCAATGCCCGGATTCGCGCGA
TCCGCTCATCGCAATTGAACGTGCGTTTGAATCCCCGGGAAGTACCGCTCGAACTGGAGGAGCTTGTCGCCTCGTTCAAC
GACATGCTCGCGCGCATCGAGGACGGCTTCGTGCAGTTGGCGAATTTTTCAGCCGACATCGCGCACGAGCTGCGCACCCC
AGTCACCAACCTGACCACGCAGACGGAGGTGGCCCTCGGTCAGTCCCGTTCCGCCGAAGAGTATCGGGAAGTGCTGTATT
CCAACCTGGAGGAGTTCGGGCGCATGAGCCGGATGATCGGGGACATGCTGTTTCTCGCGCAGACGGAGAACGATCCGCAC
AATCTCCATCGGGTGGAGATGGACCTGGGCGATACGATCAAGGGGCTCTTCGACTACTTCGAGGCTTTCGCGGAGGATTG
CAATGTGACCCTTTGTTTGCAGGGGCGGATCAAGCCAATAAGGGCCGATCGGGAGATGCTGCGGCGTGCCTTGAGCAACC
TGCTATCCAATGCCATCCGCCACACCCCGCGCGGCGCTGCCGTCACAGTGCGGCTGGGTCAGGATCAAGGACGCACCACT
GTGAGCGTCGAGAATCCCGGCAGCAAGATCGCTGATGAGGATCTGCCCAGGCTGTTCGATCGCTTCTACCGTGTCGATCC
GTCGCGGCAACGCAAGGGAGAAGGCGCTGGGTTGGGACTCGCCATCGTCAAGTCGATCGTCGAGGCACATGGCGGTGATG
TGCATGTGGCATCGGATGACACGGTAACGCGGTTCGATATTCTCCTGCCGCCAAACGACTGA

Upstream 100 bases:

>100_bases
GACGTTGCCATTCGCCGGCTGCGCGCGAAGATCGACGATGCCTTCGATCCCAAGCTCATCCATACGGTACGGGGCATGGG
CTATACGCTGGATGCCCCGG

Downstream 100 bases:

>100_bases
CGCACTGGCTTATGGGCGAGTGTCGGACCAAGGCCGCCCAGAAAACTCAGCATCCCGAGACCGGCGGCGCCGATGTCCGG
TTCCGAGACGCATAGGCCAT

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MPTKALRIRRPASLALRVTALVGIATTLVFLAFSWLIVRSLEHHFAEQDAGELRAVADAVVKPLRDPGTSTDDALLRRRL
AGAVTGHHGVFYYVADAAGTTVYAGEGPALSSLVASKRPAEAINARELASWQEQGKSYRGAVLRVQGDPSRNIRPYTVAV
AMDIDFHLAFLEDFKRMLWLATCVVLCIALLVAWLAVQWGHRPIRKVNARIRAIRSSQLNVRLNPREVPLELEELVASFN
DMLARIEDGFVQLANFSADIAHELRTPVTNLTTQTEVALGQSRSAEEYREVLYSNLEEFGRMSRMIGDMLFLAQTENDPH
NLHRVEMDLGDTIKGLFDYFEAFAEDCNVTLCLQGRIKPIRADREMLRRALSNLLSNAIRHTPRGAAVTVRLGQDQGRTT
VSVENPGSKIADEDLPRLFDRFYRVDPSRQRKGEGAGLGLAIVKSIVEAHGGDVHVASDDTVTRFDILLPPND

Sequences:

>Translated_473_residues
MPTKALRIRRPASLALRVTALVGIATTLVFLAFSWLIVRSLEHHFAEQDAGELRAVADAVVKPLRDPGTSTDDALLRRRL
AGAVTGHHGVFYYVADAAGTTVYAGEGPALSSLVASKRPAEAINARELASWQEQGKSYRGAVLRVQGDPSRNIRPYTVAV
AMDIDFHLAFLEDFKRMLWLATCVVLCIALLVAWLAVQWGHRPIRKVNARIRAIRSSQLNVRLNPREVPLELEELVASFN
DMLARIEDGFVQLANFSADIAHELRTPVTNLTTQTEVALGQSRSAEEYREVLYSNLEEFGRMSRMIGDMLFLAQTENDPH
NLHRVEMDLGDTIKGLFDYFEAFAEDCNVTLCLQGRIKPIRADREMLRRALSNLLSNAIRHTPRGAAVTVRLGQDQGRTT
VSVENPGSKIADEDLPRLFDRFYRVDPSRQRKGEGAGLGLAIVKSIVEAHGGDVHVASDDTVTRFDILLPPND
>Mature_472_residues
PTKALRIRRPASLALRVTALVGIATTLVFLAFSWLIVRSLEHHFAEQDAGELRAVADAVVKPLRDPGTSTDDALLRRRLA
GAVTGHHGVFYYVADAAGTTVYAGEGPALSSLVASKRPAEAINARELASWQEQGKSYRGAVLRVQGDPSRNIRPYTVAVA
MDIDFHLAFLEDFKRMLWLATCVVLCIALLVAWLAVQWGHRPIRKVNARIRAIRSSQLNVRLNPREVPLELEELVASFND
MLARIEDGFVQLANFSADIAHELRTPVTNLTTQTEVALGQSRSAEEYREVLYSNLEEFGRMSRMIGDMLFLAQTENDPHN
LHRVEMDLGDTIKGLFDYFEAFAEDCNVTLCLQGRIKPIRADREMLRRALSNLLSNAIRHTPRGAAVTVRLGQDQGRTTV
SVENPGSKIADEDLPRLFDRFYRVDPSRQRKGEGAGLGLAIVKSIVEAHGGDVHVASDDTVTRFDILLPPND

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=479, Percent_Identity=45.9290187891441, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788279, Length=317, Percent_Identity=31.5457413249211, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=33.9449541284404, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=28.4046692607004, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787894, Length=292, Percent_Identity=29.1095890410959, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=31.4487632508834, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=31.1594202898551, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790551, Length=272, Percent_Identity=27.2058823529412, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=26.2222222222222, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=26.5822784810127, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=25.8741258741259, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=26.4227642276423, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789149, Length=364, Percent_Identity=23.9010989010989, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=284, Percent_Identity=26.7605633802817, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=28.125, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=25.6, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=24.2105263157895, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52480; Mature: 52348

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKALRIRRPASLALRVTALVGIATTLVFLAFSWLIVRSLEHHFAEQDAGELRAVADAV
CCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VKPLRDPGTSTDDALLRRRLAGAVTGHHGVFYYVADAAGTTVYAGEGPALSSLVASKRPA
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCHHHHHHHCCCCH
EAINARELASWQEQGKSYRGAVLRVQGDPSRNIRPYTVAVAMDIDFHLAFLEDFKRMLWL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
ATCVVLCIALLVAWLAVQWGHRPIRKVNARIRAIRSSQLNVRLNPREVPLELEELVASFN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
DMLARIEDGFVQLANFSADIAHELRTPVTNLTTQTEVALGQSRSAEEYREVLYSNLEEFG
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
RMSRMIGDMLFLAQTENDPHNLHRVEMDLGDTIKGLFDYFEAFAEDCNVTLCLQGRIKPI
HHHHHHHHHHHEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
RADREMLRRALSNLLSNAIRHTPRGAAVTVRLGQDQGRTTVSVENPGSKIADEDLPRLFD
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
RFYRVDPSRQRKGEGAGLGLAIVKSIVEAHGGDVHVASDDTVTRFDILLPPND
HHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCC
>Mature Secondary Structure 
PTKALRIRRPASLALRVTALVGIATTLVFLAFSWLIVRSLEHHFAEQDAGELRAVADAV
CCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VKPLRDPGTSTDDALLRRRLAGAVTGHHGVFYYVADAAGTTVYAGEGPALSSLVASKRPA
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCHHHHHHHCCCCH
EAINARELASWQEQGKSYRGAVLRVQGDPSRNIRPYTVAVAMDIDFHLAFLEDFKRMLWL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
ATCVVLCIALLVAWLAVQWGHRPIRKVNARIRAIRSSQLNVRLNPREVPLELEELVASFN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
DMLARIEDGFVQLANFSADIAHELRTPVTNLTTQTEVALGQSRSAEEYREVLYSNLEEFG
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
RMSRMIGDMLFLAQTENDPHNLHRVEMDLGDTIKGLFDYFEAFAEDCNVTLCLQGRIKPI
HHHHHHHHHHHEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
RADREMLRRALSNLLSNAIRHTPRGAAVTVRLGQDQGRTTVSVENPGSKIADEDLPRLFD
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHH
RFYRVDPSRQRKGEGAGLGLAIVKSIVEAHGGDVHVASDDTVTRFDILLPPND
HHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]