Click here to switch to the map view.

The map label for this gene is fadE12 [H]

Identifier: 161524746

GI number: 161524746

Start: 1724311

End: 1725477

Strand: Reverse

Name: fadE12 [H]

Synonym: Bmul_1573

Alternate gene names: 161524746

Gene position: 1725477-1724311 (Counterclockwise)

Preceding gene: 161524747

Following gene: 161524745

Centisome position: 50.04

GC content: 67.61

Gene sequence:

>1167_bases
ATGCAGTTCGACCTGACCGACGATCAGCGCGCGATCGAGCGCGCGATCGACAAAATCTGCGCGCGCTTCGGCGACGACTA
CTGGCTTGAACGCGATCGCGCCGGCGGCTTCCCGCACGATTTTCACGCGGCGCTCGCGGAGGCCGGCTGGCTCGGCATCG
CGATGGATCCGGCCTACGGCGGCGCCGGCCTCGGGATGACGGAAGCGGCGCTGATGATGCGCGCGATCAGCGCGTCGGGC
GCGGGATTGTCGGGTGCGTCGGCCGTGCACATGAACATCTTCGGGCTGAATCCCGTGCAGGTGTTCGGCAGCGACGCGCA
GAAGGCGCGCTTCCTGCCGCCGCTGATCGCGGGCCGCGACAAGGCCTGCTTCGCGGTGACCGAGCCCGACGCCGGGCTCG
ACACCACGCATCTGACCACGCAGGCGCGTCGCGACGGCGATCATTACGTGCTGAGCGGCCGCAAGATCTGGATCTCGACC
GCACAGGTCGCGAACAAGATGCTGATCATCGCGCGCACGACGCCGCTCGAGCAGGTCGCGAAGCCGACCGACGGGCTCAG
CCTGTTCTATACCGATCTCGACCGTTCGCGCGTCGAAGTGCGCGAGATCGACAAGATGGGCCGCAAGGCGGTCGACTCGA
ACATGCTGTTCATCGACAACCTGCGCGTGCCGCGCGACGACCTGATCGGCGCCGAAGGCGAAGGCTTCCGCTATCTGCTG
CACGGGCTCAATCCCGAGCGCATCCTGATCGCGGCCGAAGCGATCGGCCTCGGGCAGGCGGCGCTGCGCCGCGCGACGCA
GTATGCGAACGAACGCGTGGTGTTCGGCCGGCCGATCGGGCAGAACCAGGCGATCCAGCATCCGCTCGCGCTCACGTGGA
TGCAGCTCGAGGCCGCGTGGCTGATGGTGATGAAGGCCGCGACGCGCTACGACGCGGGGCAGCCGTGCGGCGCGGAGGCC
AACGCCGCGAAATATCTCGGCGCGGAAGCCGCGTTCCATGCGTGCCAGACGGCGGTGGCGACGCACGGCGGGATGGGTTA
CGCGAAGGAATACCACGTCGAGCGCTACCTGCGCGAGTGTATGATTCCGAGGCTCGCGCCCGTGAGTCCGCAACTGATCC
TGTGCTACATCGCGGAGAAGGTGCTCGGGCTGCCGAAATCGTACTGA

Upstream 100 bases:

>100_bases
CTGTTCGCCGCCACCGTGCTGATGGTGTTCGCCGCGGTCGCGACGGGCGTGTTTCCGTTATGAGCGGCGCGGCCGTTCAC
GTTTTCCGGGAGAGCAGTCC

Downstream 100 bases:

>100_bases
TGCGCGGCGGCCGTCCGGCGCGCGTTTTCCCGTTCCGTTTCAAGCGCTCGTCATGGACGTCAAACTCGTTGCCCGCACGC
TCGACCTGTTCGAACTGTTC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQFDLTDDQRAIERAIDKICARFGDDYWLERDRAGGFPHDFHAALAEAGWLGIAMDPAYGGAGLGMTEAALMMRAISASG
AGLSGASAVHMNIFGLNPVQVFGSDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLEQVAKPTDGLSLFYTDLDRSRVEVREIDKMGRKAVDSNMLFIDNLRVPRDDLIGAEGEGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYANERVVFGRPIGQNQAIQHPLALTWMQLEAAWLMVMKAATRYDAGQPCGAEA
NAAKYLGAEAAFHACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Sequences:

>Translated_388_residues
MQFDLTDDQRAIERAIDKICARFGDDYWLERDRAGGFPHDFHAALAEAGWLGIAMDPAYGGAGLGMTEAALMMRAISASG
AGLSGASAVHMNIFGLNPVQVFGSDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLEQVAKPTDGLSLFYTDLDRSRVEVREIDKMGRKAVDSNMLFIDNLRVPRDDLIGAEGEGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYANERVVFGRPIGQNQAIQHPLALTWMQLEAAWLMVMKAATRYDAGQPCGAEA
NAAKYLGAEAAFHACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY
>Mature_388_residues
MQFDLTDDQRAIERAIDKICARFGDDYWLERDRAGGFPHDFHAALAEAGWLGIAMDPAYGGAGLGMTEAALMMRAISASG
AGLSGASAVHMNIFGLNPVQVFGSDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTPLEQVAKPTDGLSLFYTDLDRSRVEVREIDKMGRKAVDSNMLFIDNLRVPRDDLIGAEGEGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYANERVVFGRPIGQNQAIQHPLALTWMQLEAAWLMVMKAATRYDAGQPCGAEA
NAAKYLGAEAAFHACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=29.8941798941799, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4557233, Length=349, Percent_Identity=33.810888252149, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=28.1501340482574, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=28.1501340482574, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI226958412, Length=359, Percent_Identity=28.6908077994429, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=28.4615384615385, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI226958414, Length=323, Percent_Identity=29.4117647058824, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=327, Percent_Identity=29.3577981651376, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI76496475, Length=343, Percent_Identity=29.7376093294461, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557235, Length=343, Percent_Identity=29.7376093294461, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=25.7617728531856, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=25.7617728531856, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38505218, Length=294, Percent_Identity=26.8707482993197, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI211971008, Length=326, Percent_Identity=25.4601226993865, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI48976061, Length=326, Percent_Identity=25.4601226993865, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=27.906976744186, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.4611398963731, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87082384, Length=304, Percent_Identity=26.9736842105263, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081702, Length=306, Percent_Identity=23.8562091503268, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=30.749354005168, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=385, Percent_Identity=30.3896103896104, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=392, Percent_Identity=29.3367346938776, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=29.5039164490862, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=336, Percent_Identity=29.7619047619048, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17508101, Length=336, Percent_Identity=31.25, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17538396, Length=362, Percent_Identity=28.7292817679558, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=31.4487632508834, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=319, Percent_Identity=29.7805642633229, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=352, Percent_Identity=26.4204545454545, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17505929, Length=352, Percent_Identity=28.4090909090909, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=29.2372881355932, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=333, Percent_Identity=27.6276276276276, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=25.4847645429363, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=228, Percent_Identity=31.140350877193, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=27.9835390946502, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=262, Percent_Identity=29.0076335877863, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=161, Percent_Identity=27.9503105590062, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=32.6315789473684, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21356377, Length=359, Percent_Identity=32.033426183844, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=30.3763440860215, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=30.0261096605744, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=29.1105121293801, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21355753, Length=333, Percent_Identity=28.5285285285285, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI19920834, Length=296, Percent_Identity=28.3783783783784, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42380; Mature: 42380

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDLTDDQRAIERAIDKICARFGDDYWLERDRAGGFPHDFHAALAEAGWLGIAMDPAYG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRAISASGAGLSGASAVHMNIFGLNPVQVFGSDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTPLEQVA
CEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCHHHHC
KPTDGLSLFYTDLDRSRVEVREIDKMGRKAVDSNMLFIDNLRVPRDDLIGAEGEGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYANERVVFGRPIGQNQAIQHPLALTWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHCCCEEEEECCCCCCCHHCCCHHHHHHHHHHHH
LMVMKAATRYDAGQPCGAEANAAKYLGAEAAFHACQTAVATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFDLTDDQRAIERAIDKICARFGDDYWLERDRAGGFPHDFHAALAEAGWLGIAMDPAYG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRAISASGAGLSGASAVHMNIFGLNPVQVFGSDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTPLEQVA
CEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCHHHHC
KPTDGLSLFYTDLDRSRVEVREIDKMGRKAVDSNMLFIDNLRVPRDDLIGAEGEGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYANERVVFGRPIGQNQAIQHPLALTWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHCCCEEEEECCCCCCCHHCCCHHHHHHHHHHHH
LMVMKAATRYDAGQPCGAEANAAKYLGAEAAFHACQTAVATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]