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The map label for this gene is lpxB [H]

Identifier: 161524443

GI number: 161524443

Start: 1399699

End: 1400868

Strand: Direct

Name: lpxB [H]

Synonym: Bmul_1270

Alternate gene names: 161524443

Gene position: 1399699-1400868 (Clockwise)

Preceding gene: 161524442

Following gene: 161524444

Centisome position: 40.59

GC content: 69.74

Gene sequence:

>1170_bases
ATGCCGCTGCCGACCACTCAGCTCCGGCTCGCGATGGTGGCGGGCGAACCGTCCGGCGATCTGCTCGCGGCGTCGCTGCT
CGGCGGATTGCGCGAGCGGCTGCCCGCGCCGACCCACTATTACGGGATCGGCGGCGCGCGGATGATCGCGCAGGGCTTCG
ACTCGCACTGGCAGATGGACAAGCTGACGGTGCGCGGCTACGTCGAGGCGCTCGGCCAGATTCCGGAGATCCTGCGCATA
CGCGGCGAGTTGAAGCGCCAGCTGCTCGCGGAGCGGCCCGACGCGTTCATCGGCGTCGACGCGCCCGACTTCAATTTCAA
CGTCGAACAGGCGGCGCGCGACGCGGGCATTCCGTCGATCCACTTCGTCTGTCCGTCGATCTGGGCGTGGCGCGGCGGGC
GGATCAAGAAGATCGCGAAGTCCGTCGACCACATGCTCTGCCTGTTCCCGTTCGAGCCGGCGATTCTCGACAAGGCGGGC
GTCGCATCGACGTACGTCGGCCATCCGCTCGCCGACGAGATTCCGCTCGAACCCGACACGCACGGCGCGCGCATCGCGCT
CGGCCTGCCGGCCGACGGCCCCGTGATCGCGGTGCTGCCCGGCAGCCGCCGCTCGGAGATCGCGCTGATCGGCCCGACCT
TCTTCGCGGCGATGGCGCTGATGCAGCAGCGCGAGCCGGGCCTGCGCTTCGTGATGCCGGCGGCGACGCCCGCGCTGCGC
GAGTTGCTGCAGCCACTCGTCGACGCGCATCCGCAGCTTGCGCTGACGATCACCGACGGCCGCTCGCAGGTCGCGATGAC
GGCCGCCGACGCGATTCTCGTGAAGAGCGGCACCGTCACGCTCGAAGCCGCGCTGCTGAAAAAGCCGATGGTGATCTCGT
ACAAGGTGCCCTGGCTGACGGGGCAGATCATGCGCCGGCAGGGCTATCTGCCGTACGTGGGGCTGCCGAACATTCTCGCC
GGCCGCTTCGTCGTGCCCGAGCTGCTGCAGCATTTCGCGACGCCCGAGGCGCTCGCCGACGCGACGCTCACGCAGCTGCG
CGACGACGCGAATCGCCGCACGCTGACCGAAGTGTTCACGGAGATGCACCTGTCGCTGCGGCAGAATACCGCCGCGAAGG
CGGCCGAGGCCGTCGCGCGCGTGCTCGACCAGCGCAAGAGGCGCGCATGA

Upstream 100 bases:

>100_bases
GCTGCGCGAGCTCGCCCAGGCGGGCGGCGACGGCGATGCACCGGTCAATGCGCTCGTCGCGTTCATCGACGCGTCGCAGC
GCGGCATCATCCGCTAAGCG

Downstream 100 bases:

>100_bases
CGGCGGGCCGCATCACGTTCGCCGATATGCAGGCGGGCTTCGATTTCAACCGCCCGGACGAGATCGTCTGCGGCGTCGAC
GAAGCGGGGCGCGGGCCGCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPLPTTQLRLAMVAGEPSGDLLAASLLGGLRERLPAPTHYYGIGGARMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRI
RGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAG
VASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGLRFVMPAATPALR
ELLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFTEMHLSLRQNTAAKAAEAVARVLDQRKRRA

Sequences:

>Translated_389_residues
MPLPTTQLRLAMVAGEPSGDLLAASLLGGLRERLPAPTHYYGIGGARMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRI
RGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAG
VASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGLRFVMPAATPALR
ELLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFTEMHLSLRQNTAAKAAEAVARVLDQRKRRA
>Mature_388_residues
PLPTTQLRLAMVAGEPSGDLLAASLLGGLRERLPAPTHYYGIGGARMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRIR
GELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGV
ASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGLRFVMPAATPALRE
LLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAG
RFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFTEMHLSLRQNTAAKAAEAVARVLDQRKRRA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=372, Percent_Identity=40.0537634408602, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42379; Mature: 42248

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTTQLRLAMVAGEPSGDLLAASLLGGLRERLPAPTHYYGIGGARMIAQGFDSHWQMD
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCHH
KLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEEECCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGLRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHLSLRQNTAAKAAEAVARVLDQRKRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLPTTQLRLAMVAGEPSGDLLAASLLGGLRERLPAPTHYYGIGGARMIAQGFDSHWQMD
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCHH
KLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEEECCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGLRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ELLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHLSLRQNTAAKAAEAVARVLDQRKRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA