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The map label for this gene is uppS [H]

Identifier: 161524434

GI number: 161524434

Start: 1390031

End: 1390813

Strand: Direct

Name: uppS [H]

Synonym: Bmul_1261

Alternate gene names: 161524434

Gene position: 1390031-1390813 (Clockwise)

Preceding gene: 161524433

Following gene: 161524435

Centisome position: 40.31

GC content: 67.56

Gene sequence:

>783_bases
ATGACCTATACCAGCTCTACCGTTCGCGTGCCTGACGTCGGCGTCGTGCCGCGTCATATCGCGATCATCATGGACGGCAA
CGGCCGTTGGGCGACCGAACGCCGCTTGCCGCGCGTCGCCGGGCATACGCGCGGCGTCGACGCCGTGCGGGCCGTGGTCG
AAGGCTGCGCGCGCGCGGGCGTCGAATATCTGACGCTGTTCGCGTTCAGCTCGGAAAACTGGCGGCGCCCGTCCGACGAA
GTGTCGTTCCTCATGCGGCTGTTCATCACCGCGCTCGAGCGCGAGATCGGCAAGCTGCATGCGAACGGCATCCGGCTGCG
CGTGGTCGGCGATCTCGAGCGCTTCGAGCCGCGCATCCGCGAACTGATCCGCCGCGCCGAGACCAAGACGGCGCGCAACA
CGCGTCTCACGCTGACGATCGCCGCGAACTACGGCGGCCGTTGGGACATCCTGCAGGCGACGAAGAAGCTCGTCGAGCAG
GCCGCGCGCGAGGGCCGCGAGGTCGAAGTGACCGAGGAGTCCTTTGCGCCGCACCTGGCGATGGCGTACGCGCCGGAGCC
CGATTTGTTCATCCGCACGGGCGGCGAGCAGCGCGTCAGCAACTTCCTGCTGTGGCAGCTCGCCTACGCCGAGTTCTATT
TCACGAACAAATACTGGCCGGATTTCGACGGCGCGGCGCTTGCCGAAGCGCTCGCGTCGTATACCGAGCGCGAGCGCCGC
TTCGGCCGCACCAGCGCGCAGCTCGAGCCGCAGTCGCAGAACGCCGACTCCCTTTCATGCTGA

Upstream 100 bases:

>100_bases
GAAATCGACAAGCTCGTGCAGACCAAGGAAGCCGAGATCATGACGGTCTGACGACCGTCGTCGCGCGCCGCCTCCTTCCC
GCATCCCTGTCTCAACGGCC

Downstream 100 bases:

>100_bases
AAACCCGTGTGATCACGGCGATCGCGATGCTGGCAGTGCTGCTGCCGGTGACGCTGTACGCGCCGCTTGCCGCGTTCGGC
GCGCTGATCGCCGTCGTGCT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPSDE
VSFLMRLFITALEREIGKLHANGIRLRVVGDLERFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQ
AAREGREVEVTEESFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTNKYWPDFDGAALAEALASYTERERR
FGRTSAQLEPQSQNADSLSC

Sequences:

>Translated_260_residues
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPSDE
VSFLMRLFITALEREIGKLHANGIRLRVVGDLERFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQ
AAREGREVEVTEESFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTNKYWPDFDGAALAEALASYTERERR
FGRTSAQLEPQSQNADSLSC
>Mature_259_residues
TYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPSDEV
SFLMRLFITALEREIGKLHANGIRLRVVGDLERFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQA
AREGREVEVTEESFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTNKYWPDFDGAALAEALASYTERERRF
GRTSAQLEPQSQNADSLSC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=32.9004329004329, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=32.9004329004329, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1786371, Length=248, Percent_Identity=50.8064516129032, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=32.4561403508772, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=34.5291479820628, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=239, Percent_Identity=35.9832635983264, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=33.7662337662338, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29500; Mature: 29369

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAG
CCCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPSDEVSFLMRLFITALEREIGKLHANGIRLRVVGDLERFEPRIR
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQAAREGREVEVTEESFAPHLA
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCEE
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTNKYWPDFDGAALAEALASYTERERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQNADSLSC
HCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAG
CCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPSDEVSFLMRLFITALEREIGKLHANGIRLRVVGDLERFEPRIR
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQAAREGREVEVTEESFAPHLA
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCEE
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTNKYWPDFDGAALAEALASYTERERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQNADSLSC
HCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]