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The map label for this gene is acsA [H]

Identifier: 161524261

GI number: 161524261

Start: 1183350

End: 1185332

Strand: Direct

Name: acsA [H]

Synonym: Bmul_1085

Alternate gene names: 161524261

Gene position: 1183350-1185332 (Clockwise)

Preceding gene: 161524251

Following gene: 161524262

Centisome position: 34.32

GC content: 66.92

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTTCACGAAAGCCGCCAGTTTGCGCCTCCCGCGGCGCTCGAGAAGGCGGCGACCATTTC
CGGCATGGAGGCCTATCGCGCACTGGCCGCCGAGGCCGAGCGCGATTACGAAGGGTTCTGGGCGCGCCTCGCGCGCGAGG
GCCTCGCGTGGCACAAGCCGTTTACGAAGGTGCTCGACGAGTCCGATGCGCCGTTCTACAAGTGGTTCGACGACGGCGAA
CTGAATGCGTCGTACAACTGTCTCGACCGCCACGTCGAAGCCGGCAACGGCGAGCGCGTCGCGGTGATCTTCGAGGCCGA
CGACGGCACCGTCACGCGCGTCACCTATGCCGACCTGCTCGCGCGCGTCTCGCGCTTCGCCAATGCGCTGAAGAAACGCG
GCATCGGCAAGGGCGACCGCGTCGTCATCTACATGCCGATGTCGATCGAAGGCATCGTCGCGATGCAGGCCTGCGCGCGC
ATCGGCGCGACGCACTCGGTCGTGTTCGGCGGCTTCTCCGCGAAATCGCTGAACGAGCGGCTCGTCGACGTCGGTGCAGT
CGCGCTGATCACGGCCGACGAGCAGGTGCGCGGCGGCAAGACGCTGCCGCTGAAGAACATCGCCGACGAAGCGATCGCGA
TGGGCGGCTGCGACGCGGTGAAGAGCGTGATCGTCTATCGCCGCACGGGCGGCAAGATCGACTGGCATGCCGATCGCGAC
CTGTGGATGCACGAACTGGCCGACGGCGAATCCGACACCTGCGCGCCCGAATGGGTCGGCGCCGAGCATCCGCTGTTCAT
CCTCTACACGTCCGGTTCGACCGGCAAGCCGAAGGGCGTGCAGCACAGCACGGGCGGCTACCTGCTGTGGGCCGCGCAGA
CGATGAAGTGGACCTTCGACTGGAAGCCCACCGACGTGTTCTGGTGCACGGCGGACATCGGCTGGGTCACGGGCCACACC
TACATCACCTACGGTCCGCTCGCATGCGGCGGCACGCAGGTCGTGTTCGAAGGCGTGCCGACGTATCCCGATGCGGGCCG
CTTCTGGAAGATGATCGGCGATCACAAGGTCAGCGTGTTCTATACGGCGCCGACCGCGATCCGCTCGCTGATCAAGGCCG
CCGAAGCCGACGAAAAAGTGCATCCGAAGAGTTACGACCTGTCGAGCCTGCGCATCATCGGCACGGTCGGCGAGCCGATC
AATCCGGAAGCATGGATGTGGTACCACAAGCACGTCGGCCAGGAGCGCTGCCCGATCGTCGACACGTGGTGGCAGACGGA
AACCGGCGGCCACATGATCACGCCGCTGCCGGGCGCGACGCCGACGGTGCCCGGTTCATGCACGCTGCCGCTGCCGGGCA
TCATGGCCGCGGTCGTCGACGAGACGGGCCAGGACGTGCCGAACGGTCAGGGCGGCATTCTGGTCGTCAAGCGGCCGTGG
CCGTCGATGATCCGCACGATCTGGGGCGACCCGGAGCGCTTCAAGAAGAGCTACTACCCCGAGGAACTCGGCGGCACGCT
GTATCTGGCCGGCGACGGCACCGTGCGCGACAAGGACACCGGCTACTTCACGATCATGGGCCGCATCGACGACGTGCTGA
ACGTGTCCGGTCACCGGCTCGGCACGATGGAGATCGAGTCGGCGCTCGTCGCGCACGAGCTCGTGGCCGAAGCTGCGGTG
GTCGGCCGCCCCGACGACACGACGGGCGAAGCGGTGGTCGCGTTCGTCGTGCTCAAGCGCGCGCGGCCCGAAGGCGAAGA
AGCCGCGGCGCTCGCGAAGGCGCTGCGCGACTGGGTCGGCAAGCAGATCGGCCCGATCGCGAAGCCGAAGGACATCCGTT
TCGGCGACAACCTGCCGAAGACGCGCTCGGGCAAGATCATGCGGCGCCTGCTGCGCTCGCTCGCGAAGGGCGAGGCGATC
ACGCAGGACACGTCCACGCTCGAGAATCCGGCGATTCTCGAGCAGCTGACCGAAGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGGTGAGTGGGAGACAGCGGCGCCGAGGCGCCGGCCAAGACGCGGCGCGCACGATCGCGCCGCCATGCAGAGGATTCA
TGTTCACCAAGGGGTAGTCG

Downstream 100 bases:

>100_bases
TCGTCCCCGTCGCGCGCGTTGCGCGCATGAGCCCCTGCGCGGCCGTCCGGATTGTCCGCGCGGGGGCTTTTTGTCAAACA
ACGGCATGACCGTTCCGACC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLHESRQFAPPAALEKAATISGMEAYRALAAEAERDYEGFWARLAREGLAWHKPFTKVLDESDAPFYKWFDDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYMPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGAVALITADEQVRGGKTLPLKNIADEAIAMGGCDAVKSVIVYRRTGGKIDWHADRD
LWMHELADGESDTCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVSVFYTAPTAIRSLIKAAEADEKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PSMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVAHELVAEAAV
VGRPDDTTGEAVVAFVVLKRARPEGEEAAALAKALRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLTEAR

Sequences:

>Translated_660_residues
MSAIESVLHESRQFAPPAALEKAATISGMEAYRALAAEAERDYEGFWARLAREGLAWHKPFTKVLDESDAPFYKWFDDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYMPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGAVALITADEQVRGGKTLPLKNIADEAIAMGGCDAVKSVIVYRRTGGKIDWHADRD
LWMHELADGESDTCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVSVFYTAPTAIRSLIKAAEADEKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PSMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVAHELVAEAAV
VGRPDDTTGEAVVAFVVLKRARPEGEEAAALAKALRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLTEAR
>Mature_659_residues
SAIESVLHESRQFAPPAALEKAATISGMEAYRALAAEAERDYEGFWARLAREGLAWHKPFTKVLDESDAPFYKWFDDGEL
NASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYMPMSIEGIVAMQACARI
GATHSVVFGGFSAKSLNERLVDVGAVALITADEQVRGGKTLPLKNIADEAIAMGGCDAVKSVIVYRRTGGKIDWHADRDL
WMHELADGESDTCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWVTGHTY
ITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVSVFYTAPTAIRSLIKAAEADEKVHPKSYDLSSLRIIGTVGEPIN
PEAWMWYHKHVGQERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWP
SMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVAHELVAEAAVV
GRPDDTTGEAVVAFVVLKRARPEGEEAAALAKALRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAIT
QDTSTLENPAILEQLTEAR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=684, Percent_Identity=47.5146198830409, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI253970489, Length=695, Percent_Identity=46.7625899280576, Blast_Score=603, Evalue=1e-172,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=46.6772151898734, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI13375727, Length=640, Percent_Identity=38.125, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=29.1353383458647, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI122937307, Length=533, Percent_Identity=29.0806754221388, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI31982927, Length=653, Percent_Identity=26.646248085758, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=29.4559099437148, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI58082049, Length=524, Percent_Identity=28.0534351145038, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI115511026, Length=596, Percent_Identity=26.6778523489933, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI157311624, Length=507, Percent_Identity=27.6134122287968, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI157311622, Length=507, Percent_Identity=27.6134122287968, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI187761345, Length=397, Percent_Identity=27.7078085642317, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=397, Percent_Identity=27.7078085642317, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=324, Percent_Identity=25.3086419753086, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790505, Length=636, Percent_Identity=51.7295597484277, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=624, Percent_Identity=39.4230769230769, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=26.3620386643234, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI145693145, Length=538, Percent_Identity=24.1635687732342, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786810, Length=560, Percent_Identity=21.7857142857143, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=666, Percent_Identity=44.2942942942943, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71982997, Length=666, Percent_Identity=44.2942942942943, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17569507, Length=673, Percent_Identity=24.0713224368499, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=543, Percent_Identity=25.0460405156538, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=419, Percent_Identity=25.2983293556086, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=575, Percent_Identity=24.3478260869565, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=575, Percent_Identity=24.3478260869565, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=575, Percent_Identity=24.3478260869565, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=652, Percent_Identity=47.6993865030675, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319264, Length=668, Percent_Identity=46.1077844311377, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319699, Length=554, Percent_Identity=23.1046931407942, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667955, Length=675, Percent_Identity=47.1111111111111, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=50.711743772242, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24667959, Length=531, Percent_Identity=49.9058380414313, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21355225, Length=663, Percent_Identity=35.4449472096531, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=24.1904761904762, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24581924, Length=551, Percent_Identity=24.6823956442831, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72148; Mature: 72017

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLHESRQFAPPAALEKAATISGMEAYRALAAEAERDYEGFWARLAREGLAWHKP
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHCCC
FTKVLDESDAPFYKWFDDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYMPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGAVALITADEQVRGGKTLPLKNIADEAIAMGGCDAVKSVIVYRRTGGKIDWHADRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHEEEEECCCCEEEEECCCH
LWMHELADGESDTCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVSVF
CCCCEEEEEECCCCEEECCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADEKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGQERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PSMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVAHELVAEAAVVGRPDDTTGEAVVAFVVLKRARPEGEEAAALAKALRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLTEAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVLHESRQFAPPAALEKAATISGMEAYRALAAEAERDYEGFWARLAREGLAWHKP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHCCC
FTKVLDESDAPFYKWFDDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYMPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGAVALITADEQVRGGKTLPLKNIADEAIAMGGCDAVKSVIVYRRTGGKIDWHADRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHEEEEECCCCEEEEECCCH
LWMHELADGESDTCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVSVF
CCCCEEEEEECCCCEEECCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADEKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGQERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PSMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVAHELVAEAAVVGRPDDTTGEAVVAFVVLKRARPEGEEAAALAKALRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLTEAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA