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The map label for this gene is hemF [H]

Identifier: 161524158

GI number: 161524158

Start: 1075858

End: 1076781

Strand: Reverse

Name: hemF [H]

Synonym: Bmul_0982

Alternate gene names: 161524158

Gene position: 1076781-1075858 (Counterclockwise)

Preceding gene: 161524159

Following gene: 161524157

Centisome position: 31.22

GC content: 68.4

Gene sequence:

>924_bases
ATGACCGATTCGACCTACGACGTGGCGCGCGTGCGCACGTATCTCCAGGGCCTGCAGACACGCATCGCCGATGCGCTCGG
CGCGCTCGACGGCACGCCGCTTGCGACCGACATCTGGCAGCGCGGCCCCGCCGAGCGTCTGCGCGGCGGCGGCTGCACGC
GGATCCTCGAAGGCGGCCGCGTATTCGAACGCGCGGGGATCGGCTTCTCCGACGTGGCCGGCGACGCGTTGCCGCCGTCC
GCGAGCGCCGCGCGGCCGCAGCTCGCGGGGCGCGGCTTCGAGGCGCTCGGCGTGTCGCTGGTGCTGCATCCGCGCAACCC
GTACTGCCCGACCGTGCACATGAACGTGCGGATGCTGATCGCGACGAAGCCCGGCGAAGCGCCGATCTTCTGGTTCGGCG
GCGGCATGGATCTGACACCGGTTTACGGCTTCGAGGACGACGCGCGGCACTTCCATCGCACCTGCAAGGACGCACTCGAT
CCGTTCGGCGCCGAGCTGTATCCGCGCTTCAAGAAGTGGTGCGACGAGTATTTCTTCCTCAAACACCGCAACGAGATGCG
CGGCGTCGGCGGGATCTTCTTCGACGATTTCTCCGAGCCCGGCTTCGAACGTTCGTTTGAAATGATGCAGAGCGTCGGCG
ACGCCTTCCTGCCCGCCTATCTGCCGATCGTCGAGCGCCGCGCGGCGCTGCCGTACGGCGAGCGCGAGCGCGATTTCCAG
GCGTACCGCCGCGGCCGCTACGTCGAATTCAACCTCGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAAAGCGGCGGCCG
GACCGAGTCGATCCTGATGTCGATGCCGCCCGTCGCGAACTGGCGCTACAACTGGCAGCCCGAGCCCGGCTCGCCGGAAG
CGCGCCTGTATAGCGACTTCATCGTGCCGCGCGACTGGGTCTGA

Upstream 100 bases:

>100_bases
CGCCGCGCGGTGCGTCGTGCCGGCTGCCGCGGTTCGCTAGAATGCGCGGCAGAAGCCTTTTTTACGGCCCCCGCCGCGCG
CGGGGGCGTTCAGTTCAGAC

Downstream 100 bases:

>100_bases
GCCCGTCGCACTGCCCCGCCCAACAAGAGGACGCGTTTTCTGGACACCACCGCCCGCCCCGCCCCGCTGCCGCGCCGTAT
CGGCCTGCTGGGCGGCACGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDIWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYGFEDDARHFHRTCKDALD
PFGAELYPRFKKWCDEYFFLKHRNEMRGVGGIFFDDFSEPGFERSFEMMQSVGDAFLPAYLPIVERRAALPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWV

Sequences:

>Translated_307_residues
MTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDIWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYGFEDDARHFHRTCKDALD
PFGAELYPRFKKWCDEYFFLKHRNEMRGVGGIFFDDFSEPGFERSFEMMQSVGDAFLPAYLPIVERRAALPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWV
>Mature_306_residues
TDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDIWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPSA
SAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPIFWFGGGMDLTPVYGFEDDARHFHRTCKDALDP
FGAELYPRFKKWCDEYFFLKHRNEMRGVGGIFFDDFSEPGFERSFEMMQSVGDAFLPAYLPIVERRAALPYGERERDFQA
YRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=45.364238410596, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=63.1229235880399, Blast_Score=396, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320249, Length=319, Percent_Identity=44.8275862068966, Blast_Score=276, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17864388, Length=312, Percent_Identity=46.7948717948718, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34615; Mature: 34483

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDIWQRGPAERLRGGGCTRILEGGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPIFWFGGGMDLTPVYGFEDDARHFHRTCKDALDPFGAELYPRFKKWCDEYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KHRNEMRGVGGIFFDDFSEPGFERSFEMMQSVGDAFLPAYLPIVERRAALPYGERERDFQ
HHCCHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCHHHHHHH
IVPRDWV
CCCCCCC
>Mature Secondary Structure 
TDSTYDVARVRTYLQGLQTRIADALGALDGTPLATDIWQRGPAERLRGGGCTRILEGGR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPIFWFGGGMDLTPVYGFEDDARHFHRTCKDALDPFGAELYPRFKKWCDEYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KHRNEMRGVGGIFFDDFSEPGFERSFEMMQSVGDAFLPAYLPIVERRAALPYGERERDFQ
HHCCHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCHHHHHHH
IVPRDWV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA