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The map label for this gene is fabG [C]

Identifier: 161523991

GI number: 161523991

Start: 887715

End: 888530

Strand: Direct

Name: fabG [C]

Synonym: Bmul_0811

Alternate gene names: 161523991

Gene position: 887715-888530 (Clockwise)

Preceding gene: 161523990

Following gene: 161523992

Centisome position: 25.74

GC content: 65.2

Gene sequence:

>816_bases
ATGCCTACACTCGGAGCTTCTTCAACCGGAAAGGAGTCAACCGTGGCCACTCACACGCTCGCAGACAAGGTCGTCCTGAT
CGCAGGCGGCGCGAAAAACCTCGGCGGCCTGATCGCGCGGGACCTCGCGAGCCACGGCGCAAAGGCCGTGGCGATTCACT
ACAACAGCGCGGCGACGCGCGCGCAGGCCGACGAGACGGCCGCTGCGGTGCGCGCCGCCGGTGCGCAGGCCGACACGTTC
CAGGCCGACCTGACGACGGCCGCCGCGGTCGCGAAGCTGTTCGACGACGTGAAGCAGCGTTTCGGCAAGATCGACATCGC
GATCAACACGGTCGGCAAGGTGCTGAAGAAACCGATCGTCGAGATCGACGAGGCCGAATACGACGAGATGTTCGCGGTCA
ACAGCAAGTCGGCGTTCTTCTTCATCAAGGAAGCCGGCCGGCATCTCGAGGATCACGGCAAGCTCGTCACGCTCGTCACG
TCGCTGCTCGGCGCGTTCACGCCGTTCTATGCGGCGTACGAAGGATCGAAGGCGCCGGTCGAGCACTTCACGCGTGCGGC
CGCGAAGGAATACGGCGCGCGCGGGATCTCGGTGACGGCCGTCGGTCCGGGCCCGATGGATACGCCGTTCTTCTACCCGG
CCGAAGGCGCCGATGCGGTCGCGTATCACAAGACGGCGGCCGCGCTGTCGCCGTTCAGCAAGACGGGGCTGACCGACATC
GAGGACGTCGTGCCGTTCATCCGCCATCTCGTCACGGACGGCTGGTGGATCACGGGCCAGACGATCCTGATCAACGGCGG
CTATACGACTAAATAA

Upstream 100 bases:

>100_bases
GGTCACGCACCGTTCGGCGCCGCCGCCGGCTGCCGGCTGCGATTGGGCGGCTTTTCTGGATAATCCATCCAGCCGCGGCC
GGCTGACCGGCGCGGCGGGC

Downstream 100 bases:

>100_bases
GCGACGAAACAAGCGACGAAGTACGCGTCGGGCGCTGCGCGGCCGCGCCGTACTGGGCGGTTTGCGTGGACAATCGAGAG
GCGTGCGGGCATGCCCGTGC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPTLGASSTGKESTVATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAATRAQADETAAAVRAAGAQADTF
QADLTTAAAVAKLFDDVKQRFGKIDIAINTVGKVLKKPIVEIDEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVT
SLLGAFTPFYAAYEGSKAPVEHFTRAAAKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDI
EDVVPFIRHLVTDGWWITGQTILINGGYTTK

Sequences:

>Translated_271_residues
MPTLGASSTGKESTVATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAATRAQADETAAAVRAAGAQADTF
QADLTTAAAVAKLFDDVKQRFGKIDIAINTVGKVLKKPIVEIDEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVT
SLLGAFTPFYAAYEGSKAPVEHFTRAAAKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDI
EDVVPFIRHLVTDGWWITGQTILINGGYTTK
>Mature_270_residues
PTLGASSTGKESTVATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAATRAQADETAAAVRAAGAQADTFQ
ADLTTAAAVAKLFDDVKQRFGKIDIAINTVGKVLKKPIVEIDEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTS
LLGAFTPFYAAYEGSKAPVEHFTRAAAKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIE
DVVPFIRHLVTDGWWITGQTILINGGYTTK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=26.0377358490566, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=22.7611940298507, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=24.8, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789208, Length=266, Percent_Identity=27.4436090225564, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=26, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367365, Length=188, Percent_Identity=27.1276595744681, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=191, Percent_Identity=27.7486910994764, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=27.0408163265306, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=26.5917602996255, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789378, Length=203, Percent_Identity=27.0935960591133, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=27.4131274131274, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=26.0700389105058, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=28.735632183908, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=28.5171102661597, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.1954887218045, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=24.1106719367589, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=25.6603773584906, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=25.9398496240602, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=193, Percent_Identity=29.0155440414508, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=25.4752851711027, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=30.188679245283, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=30.3191489361702, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=29.0836653386454, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=26.2745098039216, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28505; Mature: 28374

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLGASSTGKESTVATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAATR
CCCCCCCCCCCCCHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHH
AQADETAAAVRAAGAQADTFQADLTTAAAVAKLFDDVKQRFGKIDIAINTVGKVLKKPIV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHH
EIDEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPV
HCCCCCCCCEEEECCCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCH
EHFTRAAAKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDI
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCH
EDVVPFIRHLVTDGWWITGQTILINGGYTTK
HHHHHHHHHHHCCCEEEECCEEEEECCCCCC
>Mature Secondary Structure 
PTLGASSTGKESTVATHTLADKVVLIAGGAKNLGGLIARDLASHGAKAVAIHYNSAATR
CCCCCCCCCCCCHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHH
AQADETAAAVRAAGAQADTFQADLTTAAAVAKLFDDVKQRFGKIDIAINTVGKVLKKPIV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHH
EIDEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPV
HCCCCCCCCEEEECCCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCH
EHFTRAAAKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDI
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCH
EDVVPFIRHLVTDGWWITGQTILINGGYTTK
HHHHHHHHHHHCCCEEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]