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The map label for this gene is clpA [H]

Identifier: 161523957

GI number: 161523957

Start: 852748

End: 855048

Strand: Direct

Name: clpA [H]

Synonym: Bmul_0777

Alternate gene names: 161523957

Gene position: 852748-855048 (Clockwise)

Preceding gene: 161523956

Following gene: 161523958

Centisome position: 24.73

GC content: 64.06

Gene sequence:

>2301_bases
ATGATTGCCCAGGAATTGGAAGTCAGCCTGCACATGGCGTTCATGGAAGCACGCCAGGCGCGCCATGAGTTCATTACGGT
CGAGCACCTGCTGCTCGCCCTGCTGGATAATCCGACGGCAGCCGAGGTGTTGCGCGCATGCGCGGCCAACATCGAGGATC
TGCGTCAGAACCTGCGCAATTTCATCCACGACAACACGCCTACCGTCCCCGGTACCGACGACGTCGATACCCAGCCGACG
CTCGGCTTTCAGCGCGTGATTCAGCGCGCGATCATGCACGTCCAGTCGACGTCGAACGGCAAGAAGGAAGTGACCGGCGC
GAACGTGCTGGTCGCGATCTTCGGCGAGAAGGACTCGCATGCCGTCTACTACCTGCAGCAGCAGGGCGTCACGCGTCTCG
ACGTCGTGAATTTCATCTCGCACGGCATCGCGAAGACGAACAGCGGCGAGGCCGCGAAGTCGGGCGATCCGAGCGCGGAA
AGCGACGACGCGAACGCGCAGAAGGAAACGCCGCTCGCGCAGTTCACGCAGAACCTGAACCAGATGGCGAAGGACGGCCG
CATCGATCCGCTGATCGGGCGCGAGCCCGAGGTCGAGCGCGTCGTGCAGGTGCTGTGCCGCCGTCGCAAGAACAATCCGC
TGCTCGTCGGCGAGGCCGGCGTCGGCAAGACCGCGATCGCGGAAGGGCTCGCGTACCGCATCACGCGCGGCGAAGTGCCC
GACATCCTCGCGAATGCGCAGGTCTACTCGCTCGACATGGGCGCGCTGCTCGCGGGCACCAAGTATCGCGGCGATTTCGA
GCAACGTCTGAAGACGGTGCTGAAGGAACTGAAGGAGCGGCCGCACGCGATTCTCTTCATCGACGAGATCCACACGCTGA
TCGGCGCGGGCGCCGCGTCGGGCGGCACGCTCGATGCGTCGAACCTGCTGAAGCCGGCGCTGTCGTCGGGCACGCTCAAG
TGCATCGGCGCGACGACGTTCACCGAATATCGCGGGATCTTCGAGAAGGATGCGGCGCTGTCGCGGCGCTTCCAGAAGGT
CGACGTGACGGAGCCGACCGTCGAGCAGACGGTCGCGATCCTGCGCGGGCTGAAGTCGCGCTTCGAGGAGCATCACGGCG
TCAAGTATTCGTCGGGCGCGTTGTCGGCCGCCGCCGAACTGTCGGCGCGCTTCATCACCGACCGTCATCTGCCCGACAAG
GCGATCGACGTGATCGACGAAGCCGGTGCCGCGCAGCGCATCCTGCCGAAGTCGAAGCAGAAGAAGACGATCGGCAAGAG
CGAGATCGAGGAAATCATTTCGAAGATCGCGCGCGTGCCGGCGCAAAGCGTGTCGCAGGACGATCGCAGCAAGCTGCAGA
CGCTCGATCGCGATCTGAAGAGCGTCGTGTTTGGCCAGGATCCGGCGATCGATGCGCTCGCGGCGTCGATCAAGATGGCA
CGCGCGGGCCTCGGCAAGATGGACAAGCCGATCGGTGCGTTCCTGTTCTCGGGCCCGACGGGCGTCGGCAAGACCGAGGT
CGCGCGTCAGCTCGCGTTCACGCTCGGCATCGAGCTGATCCGCTTCGACATGTCCGAATACATGGAGCGCCATGCGGTGA
GCCGGCTGATCGGCGCGCCGCCGGGCTACGTCGGATTCGATCAGGGCGGTCTGCTGACCGAAGCCGTCACGAAGAAGCCG
CACTGCGTGCTGCTGCTCGACGAAATCGAGAAGGCGCATCCGGACATCTTCAACGTGCTGCTGCAGGTGATGGACCACGG
CACGCTGACGGACAACAACGGCCGCAAGGCGGATTTCCGCAACGTCATCATCATCATGACGACGAACGCGGGCGCCGAGT
CGATGCAGAAGGCGACGATCGGCTTCACGACGCGTCGCGAGACCGGCGACGAGATGGCCGACATCAAGCGCCTGTTCACG
CCGGAGTTCCGCAACCGTCTCGACGCGATCATCAGCTTCCGTGCGCTCGATGAGGAAATCATCATGCGCGTGGTCGACAA
GTTCCTGATCCAGCTCGAGGAACAGCTGCACGAGAAGAAGGTCGACGCGCTGTTCACCGACGCGCTGCGCAAGCATCTGG
CGAAGCACGGCTTCGATCCGCTGATGGGTGCGCGGCCGATGCAGCGCCTGATCCAGGACACGATCCGTCGTGCGCTCGCC
GACGAGCTGCTGTTCGGCAAGCTGGTGAACGGCGGCCGCGTGACGGTCGACGTCGACGAAAACGACAAGGTGCAGCTCTC
GTTCGACAAGCTGCCGAATCCGCCGCACAAGCCGAACGAAGAGACGGTCGAAGTCGAATAA

Upstream 100 bases:

>100_bases
GTGGGGTCTATACGCGGGACATCGCGTCGACCAAAGTTGAGCAAGTCGTTACCCATGCGCGGCAGGCCGGGCATCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
GCGATAATTGCGGGTTCATCCGAACGGCGCGGGAAGTTCTCCGCGCCGTTTCGTTTTATCCGGCGCCGGCGGCGCGTTCG
TAGGGCAGGGGAGTGGCAAC

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNSGEAAKSGDPSAE
SDDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPAQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDAIISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGRVTVDVDENDKVQLSFDKLPNPPHKPNEETVEVE

Sequences:

>Translated_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNSGEAAKSGDPSAE
SDDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPAQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDAIISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGRVTVDVDENDKVQLSFDKLPNPPHKPNEETVEVE
>Mature_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTNSGEAAKSGDPSAE
SDDANAQKETPLAQFTQNLNQMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRILPKSKQKKTIGKSEIEEIISKIARVPAQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDAIISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGRVTVDVDENDKVQLSFDKLPNPPHKPNEETVEVE

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=29.2168674698795, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1787109, Length=759, Percent_Identity=61.133069828722, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=401, Percent_Identity=45.1371571072319, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=259, Percent_Identity=55.984555984556, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=300, Percent_Identity=47, Blast_Score=264, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84385; Mature: 84385

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTNSGEAAKSGDPSAESDDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPAQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFTPEFRNRLDAIISFRALDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGRVTVDVDENDKVQLSFDKLPNPPHKPNEETVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTNSGEAAKSGDPSAESDDANAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGREPEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPAQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFTPEFRNRLDAIISFRALDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGRVTVDVDENDKVQLSFDKLPNPPHKPNEETVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]