Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 161523697

GI number: 161523697

Start: 566333

End: 567160

Strand: Direct

Name: mutM [H]

Synonym: Bmul_0517

Alternate gene names: 161523697

Gene position: 566333-567160 (Clockwise)

Preceding gene: 161523689

Following gene: 161523698

Centisome position: 16.42

GC content: 70.29

Gene sequence:

>828_bases
ATGCCAGAGTTGCCAGAAGTCGAAGTCACGCGGCGGGGCATTGCGCCCTTTGTCGCGGGCCGCCGCGTCGAGCGTGTCGA
CGTCCGCACCGCGATGCTGCGCTGGCCCGTGCCGGCCGGGCTCGCGGAGCAATTGCGCGCGCGCGAGGTGCTCGCCGTCG
AGCGTCGCGGCAAGTATCTGCTGTTCGAGGTCGATGCGGGCTGGTTCATCGTCCATCTCGGCATGACGGGCACGCTGCGC
GTGCTGCCCGCAGGCGGCGTGCCCGTCGCCGCGAAGCACGATCACATCGACTGGATCTTCGACGAATTCGTGCTGCGCTT
TCGCGATCCGCGCCGGTTCGGCGCCGTGCTGTGGCATTCGCGCGAAGCGGGCGACGTGCATGCGCATCCGCTGCTCGCCA
GCCTCGGCGTCGAGCCGTTTTCGCCGGCATTCGACGGCGCGCTGCTGCATCGGCGCACGCGCGGCCGCACGGTGTCCGTC
AAGCAGGCGCTGCTCGCGGGCGACATCGTGGTCGGCGTCGGCAACATCTACGCGTCGGAGAGCCTGTTTCGCGCAGGCAT
CCGGCCGACGACGGCCGCCGGCAAGGTATCGCTGCCGCGCTACGAGCGGCTCGCCGAAGCGGTGCGCGCGACGCTCGCGG
ACGCGATCGACCGCGGCGGCAGCACGCTGCGCGATTTCGTCGGCAGCAACGGCGAGAGCGGCTACTTCCAGCTCGACTGC
TTCGTCTACGATCGCGCGGGCGAGCCGTGCCGCGTGTGCGGCACGCCGATCCGGCAGATCGTGCAGGGCCAGCGCTCGAC
TTACTTCTGTCCGACGTGCCAGCGTTGA

Upstream 100 bases:

>100_bases
GGGCAGGGTCATGGAAATCCGTTCGATGTTTCAACCGATTGTATCGCGCTCGCTACAATACACGCACGATCGTGATCATC
CAGCTTCAGACCCGCAAAAC

Downstream 100 bases:

>100_bases
ACCTTCCTTTTCCCGATTCCAAAACTTGAAGCCGCCCCGCATCGCCCCCGCTCCTTTTCCCGTCACGCCGCTGCATCGCA
CGTTCGCGCCGCGCCTCATC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLR
VLPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHSREAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSV
KQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDC
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR

Sequences:

>Translated_275_residues
MPELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLR
VLPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHSREAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSV
KQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDC
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR
>Mature_274_residues
PELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLRV
LPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHSREAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSVK
QALLAGDIVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDCF
VYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=276, Percent_Identity=48.1884057971014, Blast_Score=261, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30404; Mature: 30273

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYL
CCCCCCCHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEE
LFEVDAGWFIVHLGMTGTLRVLPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHS
EEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEC
REAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSVKQALLAGDIVVGVGNIYASE
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCEEEECCCHHHHH
SLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDC
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEE
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR
EEEECCCCCHHHCCHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVEVTRRGIAPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYL
CCCCCCHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEE
LFEVDAGWFIVHLGMTGTLRVLPAGGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHS
EEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHEEEC
REAGDVHAHPLLASLGVEPFSPAFDGALLHRRTRGRTVSVKQALLAGDIVVGVGNIYASE
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEHHHHHHHHCCEEEECCCHHHHH
SLFRAGIRPTTAAGKVSLPRYERLAEAVRATLADAIDRGGSTLRDFVGSNGESGYFQLDC
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEE
FVYDRAGEPCRVCGTPIRQIVQGQRSTYFCPTCQR
EEEECCCCCHHHCCHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA