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The map label for this gene is mutY [H]

Identifier: 161523698

GI number: 161523698

Start: 567186

End: 568298

Strand: Direct

Name: mutY [H]

Synonym: Bmul_0518

Alternate gene names: 161523698

Gene position: 567186-568298 (Clockwise)

Preceding gene: 161523697

Following gene: 161523710

Centisome position: 16.45

GC content: 70.62

Gene sequence:

>1113_bases
TTGAAGCCGCCCCGCATCGCCCCCGCTCCTTTTCCCGTCACGCCGCTGCATCGCACGTTCGCGCCGCGCCTCATCGCGTG
GCAGCGCCAGCACGGCCGCCACGACTTGCCGTGGCAGAACACGCGCGATCCGTACCGGATCTGGCTGTCGGAAATCATGC
TGCAGCAGACGCAGGTGTCGACCGTCGTGCCGTATTACACGCGCTTTCTCGAACGCTATCCGGACGTCGCCGCGCTTGCG
GCCGCGCCGATCGACGACGTGATGGCGCTGTGGGCCGGCCTCGGCTATTACTCGCGTGCGCGCAACCTGCATCGCTGCGC
GCAGGTCGTCGTCGCCGAGCACGGCGGCGCGTTTCCCGCCACGCCCGATGCGCTCGCCGACCTGCCGGGCATCGGCCGCT
CGACGGCCGCGGCGATCGCATCGTTTGCCTACGGCGCACGCGCGACGATCCTCGACGGCAACGTGAAGCGCGTGCTCGCG
CGCGTATTCGGCATCGAAGGGTTTCCGGGCGAGAAGCGCGTCGAAAACGACATGTGGGCGCTCGCCGAATCGCTGTTGCC
CGACGCGGCGCATCCGGACGACGTGAGCGCCTACACGCAGGGATTGATGGATCTCGGCGCGACGCTCTGCGTGCGCGGCA
AGCCCGACTGCGCGCGTTGTCCGTTCGCGGGCGACTGCGTCGCGCAGGCAACCGGGCGGCAGCGCGAACTGCCGGCCGCG
CGGCCGAAAAAGGCCGTGCCGACGCGCAAGACCTGGATGCTCGTGCTGCGCGACGGCGACGCCGTGCTGCTCGAGCGGCG
TCCGCCGGCCGGCATCTGGGGCGGCTTGTGGAGTTTGCCGCAGGCCGACGGCGATGCCGAGCTCGCGGATCTCGCACGCC
GTTTCGGCGGCGGCGGCCCGGTGCCGCTCGCGCCGCTCACGCATACGTTTACGCATTTCCGGCTCGAGATCGAACCGCGG
CTCAGCGATGTCGCGAGCGAGGCCGCGGCCGTGCCGTTTGCGCAGGCGCAGGATGCCGATACTGCATGGGTGCCGCTGAG
CGCGCTCGATACCTATGGCGTGCCGGCGCCGGTGCGCAAGCTGCTCGACGCGCTGAGCGGGCCGCTGCTGTAA

Upstream 100 bases:

>100_bases
GTGTGCGGCACGCCGATCCGGCAGATCGTGCAGGGCCAGCGCTCGACTTACTTCTGTCCGACGTGCCAGCGTTGAACCTT
CCTTTTCCCGATTCCAAAAC

Downstream 100 bases:

>100_bases
CGAACGAAGCCGGGCTGTGCGCGGCCGCGCTCAGAGCCAGCCGTGCCGGTCGAGCACGTGGTGAACGGCATCGATGCGCG
CGCCCACATCGGGAAACTCC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKPPRIAPAPFPVTPLHRTFAPRLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYTRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALADLPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGIEGFPGEKRVENDMWALAESLLPDAAHPDDVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQATGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPAGIWGGLWSLPQADGDAELADLARRFGGGGPVPLAPLTHTFTHFRLEIEPR
LSDVASEAAAVPFAQAQDADTAWVPLSALDTYGVPAPVRKLLDALSGPLL

Sequences:

>Translated_370_residues
MKPPRIAPAPFPVTPLHRTFAPRLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYTRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALADLPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGIEGFPGEKRVENDMWALAESLLPDAAHPDDVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQATGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPAGIWGGLWSLPQADGDAELADLARRFGGGGPVPLAPLTHTFTHFRLEIEPR
LSDVASEAAAVPFAQAQDADTAWVPLSALDTYGVPAPVRKLLDALSGPLL
>Mature_370_residues
MKPPRIAPAPFPVTPLHRTFAPRLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYTRFLERYPDVAALA
AAPIDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALADLPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGIEGFPGEKRVENDMWALAESLLPDAAHPDDVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQATGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPAGIWGGLWSLPQADGDAELADLARRFGGGGPVPLAPLTHTFTHFRLEIEPR
LSDVASEAAAVPFAQAQDADTAWVPLSALDTYGVPAPVRKLLDALSGPLL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI115298648, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI115298654, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI115298652, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI115298650, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI6912520, Length=367, Percent_Identity=35.9673024523161, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=45.1149425287356, Blast_Score=318, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40137; Mature: 40137

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPRIAPAPFPVTPLHRTFAPRLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVVPYYTRFLERYPDVAALAAAPIDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPA
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPDALADLPGIGRSTAAAIASFAYGARATILDGNVKRVLARVFGIEGFPGEKRVENDMWA
CCHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAESLLPDAAHPDDVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQATGRQRELPAA
HHHHHCCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCC
RPKKAVPTRKTWMLVLRDGDAVLLERRPPAGIWGGLWSLPQADGDAELADLARRFGGGGP
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VPLAPLTHTFTHFRLEIEPRLSDVASEAAAVPFAQAQDADTAWVPLSALDTYGVPAPVRK
CCCCHHHHCEEEEEEEECCHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHCCCCCHHHHH
LLDALSGPLL
HHHHHCCCCC
>Mature Secondary Structure
MKPPRIAPAPFPVTPLHRTFAPRLIAWQRQHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVVPYYTRFLERYPDVAALAAAPIDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPA
HHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPDALADLPGIGRSTAAAIASFAYGARATILDGNVKRVLARVFGIEGFPGEKRVENDMWA
CCHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAESLLPDAAHPDDVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQATGRQRELPAA
HHHHHCCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCC
RPKKAVPTRKTWMLVLRDGDAVLLERRPPAGIWGGLWSLPQADGDAELADLARRFGGGGP
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VPLAPLTHTFTHFRLEIEPRLSDVASEAAAVPFAQAQDADTAWVPLSALDTYGVPAPVRK
CCCCHHHHCEEEEEEEECCHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHCCCCCHHHHH
LLDALSGPLL
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]