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The map label for this gene is yciC [H]

Identifier: 161523245

GI number: 161523245

Start: 68733

End: 70034

Strand: Direct

Name: yciC [H]

Synonym: Bmul_0065

Alternate gene names: 161523245

Gene position: 68733-70034 (Clockwise)

Preceding gene: 161523244

Following gene: 161523247

Centisome position: 1.99

GC content: 67.2

Gene sequence:

>1302_bases
ATGAAACAGCCGTTGCCCGTCACCGTGCTGTCCGGCTTCCTCGGCGCCGGCAAGACCACGCTGCTCAACCATATCCTCGC
GAACCGCGCGGGCCTGAAGGTCGCCGTGATCGTCAACGACCTCGCGGCGGTCAACATCGACGCGTCGATCGTGCGCGACG
CGCAGGCGCTGTCGCATGTCGAGGAACGGCTCGTCGAGATGTCGAACGGCTGTATCTGCTGCACGCTGCGCGACGATCTG
CTCGTCGAGATCCGCCAGCTCGCGGCGGAAGGCCGCTTCGACGCGATCGTGATCGAATCGACCGGTATCGCGGAGCCGAT
GCCGATCGCCGAGACCTTCACGTTCGTCGACGACGACGGCACGTCGCTCGGCGACACCGCACGGCTCGACACGCTCGTCA
CGGTCGTCGACGCATTCAATTTCCTGCGCGACTACGGCTCGGACGACGCACTCGCAACGCGCGGCATCGCCGCCTCCGAA
GACGACGATCGCACGCTCGTCGAGCTGCTGATCGAGCAGATCGAATTCTGCGACGTGCTCGTGATCAACAAGGCCGACCT
CGTCAGCGCGGACGAACTCGCGCGGCTGCAACACATTCTCGCGCGGCTCAATCCGCGCGCGCATCAGGTCGTGTCGACGT
TCGGCAACGTGCCGCTCGACGCGGTGCTGAACACCGGCCGCTTCGATTTCGACGAAGCGGCGAACGCGCCCGGCTGGCTC
GCGTCGCTCGATCGCGATCATGCGTACTGCGACGATCCCGACTGCGACGCGCATCATCATGCGCACGTGCACGGCGAAGC
GGATGAATTCGGCATTGCGAATTTCGTTTACCGCGCGCGCCGGCCGTTTCATCCGGCGCGGCTCTGGGCGCTGCTCCATC
AACAGTGGCCGGGCGTGCTGCGCAGCAAGGGCTTCTTCTGGCTCGCGACGCGCAACGACATCGCGGGCTCGCTGTCGCAG
GCGGGCGGCGTGTGCCGGCACGGCCCGGCCGGGCTCTGGTGGGCCGCGCAGGATCGCGCGGAATGGCCGGACGACGACGA
ACTGCTCGCCGAAATTCGCACTGAATGGGAAGGCGATTTCGACGACCGCTCGATCGGCGATCGCCGTCAGGAACTCGTGC
TGATCGGCATCGCGCTCGACGCCGACGCGTGGCGCGCGAAGCTCGACGCCTGCCTGCTGACCGATGCGGAATTCGCGCTC
GGCGCGGCCGGATGGGCCGCGTTCGACGACCCGTTCCCTGCATGGGACGTCGACGCGCACGACGACGAAGACCCGGGCGA
CGCGCAGATCGTGCGCCCGTAA

Upstream 100 bases:

>100_bases
GGGCTTACGCTGCGGCTTCGCGCGCGCGAACGGCCCGGCCGCTCGTGCCGCGCAGCGGCGCCGCGGCCGCTTTTTCACTT
TTCCGTTGGTGCGTACCGCA

Downstream 100 bases:

>100_bases
CAGCGATCGACGAACCGTAAAATCTTGTAAAGGTGTGACGGACTGTGGCAAAAATGCCGCGCGCACCCAACAAAAAACCC
GCCGAAAGGCGGGTTTTTTT

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASIVRDAQALSHVEERLVEMSNGCICCTLRDDL
LVEIRQLAAEGRFDAIVIESTGIAEPMPIAETFTFVDDDGTSLGDTARLDTLVTVVDAFNFLRDYGSDDALATRGIAASE
DDDRTLVELLIEQIEFCDVLVINKADLVSADELARLQHILARLNPRAHQVVSTFGNVPLDAVLNTGRFDFDEAANAPGWL
ASLDRDHAYCDDPDCDAHHHAHVHGEADEFGIANFVYRARRPFHPARLWALLHQQWPGVLRSKGFFWLATRNDIAGSLSQ
AGGVCRHGPAGLWWAAQDRAEWPDDDELLAEIRTEWEGDFDDRSIGDRRQELVLIGIALDADAWRAKLDACLLTDAEFAL
GAAGWAAFDDPFPAWDVDAHDDEDPGDAQIVRP

Sequences:

>Translated_433_residues
MKQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASIVRDAQALSHVEERLVEMSNGCICCTLRDDL
LVEIRQLAAEGRFDAIVIESTGIAEPMPIAETFTFVDDDGTSLGDTARLDTLVTVVDAFNFLRDYGSDDALATRGIAASE
DDDRTLVELLIEQIEFCDVLVINKADLVSADELARLQHILARLNPRAHQVVSTFGNVPLDAVLNTGRFDFDEAANAPGWL
ASLDRDHAYCDDPDCDAHHHAHVHGEADEFGIANFVYRARRPFHPARLWALLHQQWPGVLRSKGFFWLATRNDIAGSLSQ
AGGVCRHGPAGLWWAAQDRAEWPDDDELLAEIRTEWEGDFDDRSIGDRRQELVLIGIALDADAWRAKLDACLLTDAEFAL
GAAGWAAFDDPFPAWDVDAHDDEDPGDAQIVRP
>Mature_433_residues
MKQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASIVRDAQALSHVEERLVEMSNGCICCTLRDDL
LVEIRQLAAEGRFDAIVIESTGIAEPMPIAETFTFVDDDGTSLGDTARLDTLVTVVDAFNFLRDYGSDDALATRGIAASE
DDDRTLVELLIEQIEFCDVLVINKADLVSADELARLQHILARLNPRAHQVVSTFGNVPLDAVLNTGRFDFDEAANAPGWL
ASLDRDHAYCDDPDCDAHHHAHVHGEADEFGIANFVYRARRPFHPARLWALLHQQWPGVLRSKGFFWLATRNDIAGSLSQ
AGGVCRHGPAGLWWAAQDRAEWPDDDELLAEIRTEWEGDFDDRSIGDRRQELVLIGIALDADAWRAKLDACLLTDAEFAL
GAAGWAAFDDPFPAWDVDAHDDEDPGDAQIVRP

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI146231952, Length=229, Percent_Identity=32.7510917030568, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33469141, Length=229, Percent_Identity=33.1877729257642, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148727351, Length=229, Percent_Identity=32.3144104803493, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI126722884, Length=229, Percent_Identity=32.3144104803493, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223941779, Length=204, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223941776, Length=219, Percent_Identity=31.9634703196347, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI119120938, Length=143, Percent_Identity=38.4615384615385, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI87082430, Length=234, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788499, Length=109, Percent_Identity=35.7798165137615, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324356, Length=237, Percent_Identity=28.2700421940928, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 47485; Mature: 47485

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASIVRDAQALSHV
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHHHHHHHH
EERLVEMSNGCICCTLRDDLLVEIRQLAAEGRFDAIVIESTGIAEPMPIAETFTFVDDDG
HHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHEEEEECCCC
TSLGDTARLDTLVTVVDAFNFLRDYGSDDALATRGIAASEDDDRTLVELLIEQIEFCDVL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEE
VINKADLVSADELARLQHILARLNPRAHQVVSTFGNVPLDAVLNTGRFDFDEAANAPGWL
EECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCCCCHH
ASLDRDHAYCDDPDCDAHHHAHVHGEADEFGIANFVYRARRPFHPARLWALLHQQWPGVL
HHCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHH
RSKGFFWLATRNDIAGSLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLAEIRTEWEGDF
HCCCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCC
DDRSIGDRRQELVLIGIALDADAWRAKLDACLLTDAEFALGAAGWAAFDDPFPAWDVDAH
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHHEECCCHHHHCCCCCCCCCCCCCCCCCCCC
DDEDPGDAQIVRP
CCCCCCCCEEECC
>Mature Secondary Structure
MKQPLPVTVLSGFLGAGKTTLLNHILANRAGLKVAVIVNDLAAVNIDASIVRDAQALSHV
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHHHHHHHH
EERLVEMSNGCICCTLRDDLLVEIRQLAAEGRFDAIVIESTGIAEPMPIAETFTFVDDDG
HHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHEEEEECCCC
TSLGDTARLDTLVTVVDAFNFLRDYGSDDALATRGIAASEDDDRTLVELLIEQIEFCDVL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEE
VINKADLVSADELARLQHILARLNPRAHQVVSTFGNVPLDAVLNTGRFDFDEAANAPGWL
EECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCCCCHH
ASLDRDHAYCDDPDCDAHHHAHVHGEADEFGIANFVYRARRPFHPARLWALLHQQWPGVL
HHCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHH
RSKGFFWLATRNDIAGSLSQAGGVCRHGPAGLWWAAQDRAEWPDDDELLAEIRTEWEGDF
HCCCEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCC
DDRSIGDRRQELVLIGIALDADAWRAKLDACLLTDAEFALGAAGWAAFDDPFPAWDVDAH
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHHEECCCHHHHCCCCCCCCCCCCCCCCCCCC
DDEDPGDAQIVRP
CCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]