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The map label for this gene is purE [H]

Identifier: 160903384

GI number: 160903384

Start: 2164628

End: 2165047

Strand: Direct

Name: purE [H]

Synonym: Pmob_1955

Alternate gene names: 160903384

Gene position: 2164628-2165047 (Clockwise)

Preceding gene: 160903383

Following gene: 160903385

Centisome position: 99.77

GC content: 38.81

Gene sequence:

>420_bases
TTGAGTAAGAAAGTCCTTTTGATATCTGGAAGTCAATCAGATGAGATTTTTGTAAAAACTGCCATTGACCTCTTTGAAGA
ATGGAAGATAAGTTACGACTATAAGGTGTTTAGTGCTCACAGAAATTTGAAAGAGCTAACAAAATTTATCGAAGAACTTC
CAAGTAACGAATATTGTGTCATAATAGCTGTTGCCGGCCTTTCTGCTGCCTTACCTGGTGTAATCGCTTCATTAACTAAT
CTCCCCGTTGTTGGTGTCCCCAGAGATGTAGGTCCTTTAAATGGAATAGATGCATTACTTTCTATGGTACAGATGCCTAG
TGGGGTTCCTGTTGCAACCATGGGCATTGGAAGTAGTGGTATGAAAAATGCAGCATACTTTGCAAAAAGGTTGACAGAAG
GTGAAAAAGATGGAAGATAA

Upstream 100 bases:

>100_bases
AGTAAGAGGGGTCTGAGATATTGTATATCAACATCCTACCTCTCTACTGTATGAGAGGTAGGATTTTTTATTTCAACATT
TTAAAAAAGGAGAGATAACT

Downstream 100 bases:

>100_bases
GAAAAATTTTGAGCTTTTATACGAAGGGAAAGCCAAAAAAGTATACAAGTTCGATGAGAAGAAATTGTTGATAGAATTCA
AAGATGATGTGACAGCATTC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSKKVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCVIIAVAGLSAALPGVIASLTN
LPVVGVPRDVGPLNGIDALLSMVQMPSGVPVATMGIGSSGMKNAAYFAKRLTEGEKDGR

Sequences:

>Translated_139_residues
MSKKVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCVIIAVAGLSAALPGVIASLTN
LPVVGVPRDVGPLNGIDALLSMVQMPSGVPVATMGIGSSGMKNAAYFAKRLTEGEKDGR
>Mature_138_residues
SKKVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCVIIAVAGLSAALPGVIASLTNL
PVVGVPRDVGPLNGIDALLSMVQMPSGVPVATMGIGSSGMKNAAYFAKRLTEGEKDGR

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=44.1441441441441, Blast_Score=93, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=125, Percent_Identity=40, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 14935; Mature: 14803

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCV
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEE
IIAVAGLSAALPGVIASLTNLPVVGVPRDVGPLNGIDALLSMVQMPSGVPVATMGIGSSG
EEEECCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCC
MKNAAYFAKRLTEGEKDGR
CHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKKVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCV
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHCCCCCEEE
IIAVAGLSAALPGVIASLTNLPVVGVPRDVGPLNGIDALLSMVQMPSGVPVATMGIGSSG
EEEECCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCC
MKNAAYFAKRLTEGEKDGR
CHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]