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The map label for this gene is gcvPA [H]

Identifier: 160903342

GI number: 160903342

Start: 2117476

End: 2118822

Strand: Direct

Name: gcvPA [H]

Synonym: Pmob_1913

Alternate gene names: 160903342

Gene position: 2117476-2118822 (Clockwise)

Preceding gene: 160903341

Following gene: 160903343

Centisome position: 97.6

GC content: 34.89

Gene sequence:

>1347_bases
ATGAATGATTTTCCATATTTACCCCATACCCAAAAAGACATAGAAGAAATGTTCTCTTTTTTGGGAATAAAAGATATAGA
TGAACTTTATCGAGATATTCCAGCACTGTTCAAAGGTGAGTTGAATATCCCATCGGGTTTGAGTGAATTAGAAGTTAAAG
AAAGGCTAACCGATTTATCGCAAATGAATAAAAATATGGAAGAATACGGGATTTTTAGAGGTGCGGGAATTTACAATCAT
TATATTCCTTCTGTGATATATCCTTTAGCTTCAAATAGGAATTTTTTAACTGCATATACGCCTTACCAGGCTGAAGTTTC
TCAGGGTACCCTCCAAATACTCTATGAGTATCAAACTCAAATTTGCAATCTTACGGGGATGGAAGTTTCTAATTCATCTA
TGTACGATGGTGCTTCAGCTTTAGCTGAGGCTATTTTAATGGCAAAAAGAATTAATGGTAAAAATCATGTTTTGATGTCT
AAAACGGTTCATCCCGAGTATCAAGAAGTATCAAAAACCTATGTTGAAGTGCAAGGGATGAATATAGAGCAAATAGGCTA
TTTATCTGAAACGGGTCAATTAGATCTAGATGAATTAACTTCTAAAATCACCCAAGAAACATCTTGTGTTGTAGTTTCAT
ATCCAAACTTTTTTGGTGTAATAGAAGATTTGAAAGCGATAAGAGAAAAGGTTCCTAGCGATGTTATTTTCATTGTAGTT
ACCTATCCAATCTCTTTAGGGTTGTTAGAAACTCCTGGAAAATTTGGGGTGGATATAGTAGTAGGAGAAGGTCAATCTTT
AGGAAATACACCTTCATTTGGGGGACCGGGTTTGGGAATCTTCGCTTCCAAAAAAAAGTACATCCGAAAGATGCCTGGCA
GAATTATCGGTGAAACCGTGGATCAAGATGGTAAAAGAGGATTTTGCATGATTTTGCAGACAAGGGAACAACATATAAGA
AGAGAGAAGGCTACTTCTAATATATGTTCAAATCATGCATTCAATGCTCTTTTGGCTTCTTTGTATATGAATGTGATGGG
AAAGCAAGGGATAAGAGAAGTTTCTCTTCAGAATTATCATAAAGCCCATTATCTAGCAAAAAAATTGGTAGAGACTGAAA
AGTTTAAACCTGTATTTGACGGACCATTTTTTAACGAGTTTGTATTAGAAAGCAAAATTGATCCTGATCTTCTCAACGAA
AAACTGTTGGAGCAACATTATTTTGGACCTTTGATACTGAAGAATTTTTATGAAGAAATGGGGAATAAGGTACTGTTTTG
TGCAACAGAACTGACTAAAAAAAGAGATATCGACTTTTTATGTTCTTTCTTGGAGGGATTATCATGA

Upstream 100 bases:

>100_bases
CGTTTTATAAAGGAAGTGTAAAAAGCACAAAGTAAAAATACGGGCAAAGGGGCGCTATATCAACTTTTATAAGAATAATA
AAAAGAGGTGAGATGTTATA

Downstream 100 bases:

>100_bases
AATTGATATTTGAAAAATCAGTTAGCGGGAGAACATCATATTCGCTTCCTAAATTGGATGTCAAAGAATCTCAGATAGAT
ATACCAGAACATTTAGTTAG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNDFPYLPHTQKDIEEMFSFLGIKDIDELYRDIPALFKGELNIPSGLSELEVKERLTDLSQMNKNMEEYGIFRGAGIYNH
YIPSVIYPLASNRNFLTAYTPYQAEVSQGTLQILYEYQTQICNLTGMEVSNSSMYDGASALAEAILMAKRINGKNHVLMS
KTVHPEYQEVSKTYVEVQGMNIEQIGYLSETGQLDLDELTSKITQETSCVVVSYPNFFGVIEDLKAIREKVPSDVIFIVV
TYPISLGLLETPGKFGVDIVVGEGQSLGNTPSFGGPGLGIFASKKKYIRKMPGRIIGETVDQDGKRGFCMILQTREQHIR
REKATSNICSNHAFNALLASLYMNVMGKQGIREVSLQNYHKAHYLAKKLVETEKFKPVFDGPFFNEFVLESKIDPDLLNE
KLLEQHYFGPLILKNFYEEMGNKVLFCATELTKKRDIDFLCSFLEGLS

Sequences:

>Translated_448_residues
MNDFPYLPHTQKDIEEMFSFLGIKDIDELYRDIPALFKGELNIPSGLSELEVKERLTDLSQMNKNMEEYGIFRGAGIYNH
YIPSVIYPLASNRNFLTAYTPYQAEVSQGTLQILYEYQTQICNLTGMEVSNSSMYDGASALAEAILMAKRINGKNHVLMS
KTVHPEYQEVSKTYVEVQGMNIEQIGYLSETGQLDLDELTSKITQETSCVVVSYPNFFGVIEDLKAIREKVPSDVIFIVV
TYPISLGLLETPGKFGVDIVVGEGQSLGNTPSFGGPGLGIFASKKKYIRKMPGRIIGETVDQDGKRGFCMILQTREQHIR
REKATSNICSNHAFNALLASLYMNVMGKQGIREVSLQNYHKAHYLAKKLVETEKFKPVFDGPFFNEFVLESKIDPDLLNE
KLLEQHYFGPLILKNFYEEMGNKVLFCATELTKKRDIDFLCSFLEGLS
>Mature_448_residues
MNDFPYLPHTQKDIEEMFSFLGIKDIDELYRDIPALFKGELNIPSGLSELEVKERLTDLSQMNKNMEEYGIFRGAGIYNH
YIPSVIYPLASNRNFLTAYTPYQAEVSQGTLQILYEYQTQICNLTGMEVSNSSMYDGASALAEAILMAKRINGKNHVLMS
KTVHPEYQEVSKTYVEVQGMNIEQIGYLSETGQLDLDELTSKITQETSCVVVSYPNFFGVIEDLKAIREKVPSDVIFIVV
TYPISLGLLETPGKFGVDIVVGEGQSLGNTPSFGGPGLGIFASKKKYIRKMPGRIIGETVDQDGKRGFCMILQTREQHIR
REKATSNICSNHAFNALLASLYMNVMGKQGIREVSLQNYHKAHYLAKKLVETEKFKPVFDGPFFNEFVLESKIDPDLLNE
KLLEQHYFGPLILKNFYEEMGNKVLFCATELTKKRDIDFLCSFLEGLS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=363, Percent_Identity=34.435261707989, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1789269, Length=365, Percent_Identity=34.2465753424658, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=365, Percent_Identity=35.0684931506849, Blast_Score=195, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6323843, Length=417, Percent_Identity=30.6954436450839, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24645648, Length=368, Percent_Identity=36.1413043478261, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 50644; Mature: 50644

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFPYLPHTQKDIEEMFSFLGIKDIDELYRDIPALFKGELNIPSGLSELEVKERLTDLS
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QMNKNMEEYGIFRGAGIYNHYIPSVIYPLASNRNFLTAYTPYQAEVSQGTLQILYEYQTQ
HHHCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
ICNLTGMEVSNSSMYDGASALAEAILMAKRINGKNHVLMSKTVHPEYQEVSKTYVEVQGM
HHCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHEECC
NIEQIGYLSETGQLDLDELTSKITQETSCVVVSYPNFFGVIEDLKAIREKVPSDVIFIVV
CHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEE
TYPISLGLLETPGKFGVDIVVGEGQSLGNTPSFGGPGLGIFASKKKYIRKMPGRIIGETV
ECCCEECEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
DQDGKRGFCMILQTREQHIRREKATSNICSNHAFNALLASLYMNVMGKQGIREVSLQNYH
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAHYLAKKLVETEKFKPVFDGPFFNEFVLESKIDPDLLNEKLLEQHYFGPLILKNFYEEM
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GNKVLFCATELTKKRDIDFLCSFLEGLS
CCEEEEEEHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MNDFPYLPHTQKDIEEMFSFLGIKDIDELYRDIPALFKGELNIPSGLSELEVKERLTDLS
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QMNKNMEEYGIFRGAGIYNHYIPSVIYPLASNRNFLTAYTPYQAEVSQGTLQILYEYQTQ
HHHCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
ICNLTGMEVSNSSMYDGASALAEAILMAKRINGKNHVLMSKTVHPEYQEVSKTYVEVQGM
HHCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHEECC
NIEQIGYLSETGQLDLDELTSKITQETSCVVVSYPNFFGVIEDLKAIREKVPSDVIFIVV
CHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEE
TYPISLGLLETPGKFGVDIVVGEGQSLGNTPSFGGPGLGIFASKKKYIRKMPGRIIGETV
ECCCEECEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
DQDGKRGFCMILQTREQHIRREKATSNICSNHAFNALLASLYMNVMGKQGIREVSLQNYH
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAHYLAKKLVETEKFKPVFDGPFFNEFVLESKIDPDLLNEKLLEQHYFGPLILKNFYEEM
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GNKVLFCATELTKKRDIDFLCSFLEGLS
CCEEEEEEHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]