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The map label for this gene is gcvPB [H]

Identifier: 160903343

GI number: 160903343

Start: 2118819

End: 2120255

Strand: Direct

Name: gcvPB [H]

Synonym: Pmob_1914

Alternate gene names: 160903343

Gene position: 2118819-2120255 (Clockwise)

Preceding gene: 160903342

Following gene: 160903345

Centisome position: 97.66

GC content: 35.21

Gene sequence:

>1437_bases
ATGAAATTGATATTTGAAAAATCAGTTAGCGGGAGAACATCATATTCGCTTCCTAAATTGGATGTCAAAGAATCTCAGAT
AGATATACCAGAACATTTAGTTAGAAATGAAGCTCCGAATCTACCAGAACTTTACGAAGTTGATGTTGTTAGACATTACA
ATCAATTAGCCAGTCTAAACCATTCGGTTGATAGAGGTTTTTATCCTTTGGGTTCTTGTACAATGAAATACAATCCTTTT
CTGAATGAAGAGGCTGCATCTTTGAATGGATTCAAATTTATTCATCCCTATCAAGAGGAAAGTACAGTACAAGGTGCGTT
GGAATTGATGTATGAATTACAAGAATTTCTCAAAGAGATAACAGGGATGGATTATGTTACCCTGCAGCCTGCTGCTGGTG
CCCATGGGGAGCTTACAGGAATGCTTGTTATTAAGAAATATCTACAAGAAAATAATTTAGGTCATAAAAATGAAGTTATC
ATACCAGATTCCGCTCATGGTACGAATCCTGCATCTGCGGTAATGGCAGGGTTTGAAGTGGTTAAAGTTAATTCGAATAA
TGAGGGAAGAGTCGATTTAGATCATTTGAAATCTTTAGTGAATGAAAATACTGCCGCTATTATGCTCACAAACCCAAATA
CTTTGGGATTGTTTGAAAAAGATATTCTGAAGATATCTGATTTGATGCATAAAAACAATGCCTTGTTGTACTACGATGGG
GCGAATTTAAACGCAATAATGGGAAAAGTAAGACCTGGAGATAATGGTTTCGATGTTGTTCATCTAAATCTACACAAAAC
ATTTTCCACCCCTCATGGAATGGGGGGACCTGGGAGTGGTCCTATAGCGGTAAAGTCTTTTTTAAAAGAGTATTTGCCTA
AACCTATTGTGGGTATGAAAGAAAGTGGGGAATATTATTTTGATTATGATATCCCTAAAAGCATTGGTAAAGTACGTAGC
TTTTATGGTAATTTTTTAGTACTAATCAAAGCATACACTTACATATTATCAATGGGCAAAGAAGGTTTGAAGAAGGTAAG
TGAACTTGCAACTTTAAATGCGAATTATTTGAAAGAGAAGTTGTCGAAATTTTTAGACGTTGCTTATCCAGATGTCTGTA
AGCATGAGTTTGTAATAAAAGGGACTTCGTTGAAAGATTATGGTGTAAGCACACTGGATTTTGCAAAAAGGCTCTTAGAT
TATGGTATGCATCCTCCAACAGTTTATTTTCCTTTGATAGTGGATGAAGCAATGATGATCGAACCAACCGAAACTGAAAG
CAAAGAAACCTTGGATGAAGTTGCTTCTATATATGAGAAAATCTTAGAAGAAGCCAGAAAAGAACCAGATAAGTTAAAAG
AAGCTCCTTTGACTTTAACTATTAAAAGATTGGACGAAATAAAAGCCAATAAGGATTTAAAGGTAAAATTTGAGTAG

Upstream 100 bases:

>100_bases
ATTTTTATGAAGAAATGGGGAATAAGGTACTGTTTTGTGCAACAGAACTGACTAAAAAAAGAGATATCGACTTTTTATGT
TCTTTCTTGGAGGGATTATC

Downstream 100 bases:

>100_bases
GCGTTGATAAGTTGGGGATGAGAGTTGAAGGTATTTGTTATATTAAGTCAAAAAAACAGTGAGGCAAAAATATCGACTTA
CGCCTCACTGTTTTCTTGTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKLIFEKSVSGRTSYSLPKLDVKESQIDIPEHLVRNEAPNLPELYEVDVVRHYNQLASLNHSVDRGFYPLGSCTMKYNPF
LNEEAASLNGFKFIHPYQEESTVQGALELMYELQEFLKEITGMDYVTLQPAAGAHGELTGMLVIKKYLQENNLGHKNEVI
IPDSAHGTNPASAVMAGFEVVKVNSNNEGRVDLDHLKSLVNENTAAIMLTNPNTLGLFEKDILKISDLMHKNNALLYYDG
ANLNAIMGKVRPGDNGFDVVHLNLHKTFSTPHGMGGPGSGPIAVKSFLKEYLPKPIVGMKESGEYYFDYDIPKSIGKVRS
FYGNFLVLIKAYTYILSMGKEGLKKVSELATLNANYLKEKLSKFLDVAYPDVCKHEFVIKGTSLKDYGVSTLDFAKRLLD
YGMHPPTVYFPLIVDEAMMIEPTETESKETLDEVASIYEKILEEARKEPDKLKEAPLTLTIKRLDEIKANKDLKVKFE

Sequences:

>Translated_478_residues
MKLIFEKSVSGRTSYSLPKLDVKESQIDIPEHLVRNEAPNLPELYEVDVVRHYNQLASLNHSVDRGFYPLGSCTMKYNPF
LNEEAASLNGFKFIHPYQEESTVQGALELMYELQEFLKEITGMDYVTLQPAAGAHGELTGMLVIKKYLQENNLGHKNEVI
IPDSAHGTNPASAVMAGFEVVKVNSNNEGRVDLDHLKSLVNENTAAIMLTNPNTLGLFEKDILKISDLMHKNNALLYYDG
ANLNAIMGKVRPGDNGFDVVHLNLHKTFSTPHGMGGPGSGPIAVKSFLKEYLPKPIVGMKESGEYYFDYDIPKSIGKVRS
FYGNFLVLIKAYTYILSMGKEGLKKVSELATLNANYLKEKLSKFLDVAYPDVCKHEFVIKGTSLKDYGVSTLDFAKRLLD
YGMHPPTVYFPLIVDEAMMIEPTETESKETLDEVASIYEKILEEARKEPDKLKEAPLTLTIKRLDEIKANKDLKVKFE
>Mature_478_residues
MKLIFEKSVSGRTSYSLPKLDVKESQIDIPEHLVRNEAPNLPELYEVDVVRHYNQLASLNHSVDRGFYPLGSCTMKYNPF
LNEEAASLNGFKFIHPYQEESTVQGALELMYELQEFLKEITGMDYVTLQPAAGAHGELTGMLVIKKYLQENNLGHKNEVI
IPDSAHGTNPASAVMAGFEVVKVNSNNEGRVDLDHLKSLVNENTAAIMLTNPNTLGLFEKDILKISDLMHKNNALLYYDG
ANLNAIMGKVRPGDNGFDVVHLNLHKTFSTPHGMGGPGSGPIAVKSFLKEYLPKPIVGMKESGEYYFDYDIPKSIGKVRS
FYGNFLVLIKAYTYILSMGKEGLKKVSELATLNANYLKEKLSKFLDVAYPDVCKHEFVIKGTSLKDYGVSTLDFAKRLLD
YGMHPPTVYFPLIVDEAMMIEPTETESKETLDEVASIYEKILEEARKEPDKLKEAPLTLTIKRLDEIKANKDLKVKFE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=433, Percent_Identity=40.6466512702078, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1789269, Length=416, Percent_Identity=39.1826923076923, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17535605, Length=489, Percent_Identity=37.2188139059305, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI32564013, Length=385, Percent_Identity=41.038961038961, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=450, Percent_Identity=42.8888888888889, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24645648, Length=431, Percent_Identity=41.0672853828306, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53633; Mature: 53633

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIFEKSVSGRTSYSLPKLDVKESQIDIPEHLVRNEAPNLPELYEVDVVRHYNQLASLN
CCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
HSVDRGFYPLGSCTMKYNPFLNEEAASLNGFKFIHPYQEESTVQGALELMYELQEFLKEI
CHHHCCCCCCCCCEEEECCCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TGMDYVTLQPAAGAHGELTGMLVIKKYLQENNLGHKNEVIIPDSAHGTNPASAVMAGFEV
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCEEE
VKVNSNNEGRVDLDHLKSLVNENTAAIMLTNPNTLGLFEKDILKISDLMHKNNALLYYDG
EEECCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECC
ANLNAIMGKVRPGDNGFDVVHLNLHKTFSTPHGMGGPGSGPIAVKSFLKEYLPKPIVGMK
CCCEEHEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
ESGEYYFDYDIPKSIGKVRSFYGNFLVLIKAYTYILSMGKEGLKKVSELATLNANYLKEK
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHH
LSKFLDVAYPDVCKHEFVIKGTSLKDYGVSTLDFAKRLLDYGMHPPTVYFPLIVDEAMMI
HHHHHHCCCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHEEECCEEEE
EPTETESKETLDEVASIYEKILEEARKEPDKLKEAPLTLTIKRLDEIKANKDLKVKFE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKLIFEKSVSGRTSYSLPKLDVKESQIDIPEHLVRNEAPNLPELYEVDVVRHYNQLASLN
CCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
HSVDRGFYPLGSCTMKYNPFLNEEAASLNGFKFIHPYQEESTVQGALELMYELQEFLKEI
CHHHCCCCCCCCCEEEECCCCCCHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TGMDYVTLQPAAGAHGELTGMLVIKKYLQENNLGHKNEVIIPDSAHGTNPASAVMAGFEV
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCEEE
VKVNSNNEGRVDLDHLKSLVNENTAAIMLTNPNTLGLFEKDILKISDLMHKNNALLYYDG
EEECCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECC
ANLNAIMGKVRPGDNGFDVVHLNLHKTFSTPHGMGGPGSGPIAVKSFLKEYLPKPIVGMK
CCCEEHEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
ESGEYYFDYDIPKSIGKVRSFYGNFLVLIKAYTYILSMGKEGLKKVSELATLNANYLKEK
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHH
LSKFLDVAYPDVCKHEFVIKGTSLKDYGVSTLDFAKRLLDYGMHPPTVYFPLIVDEAMMI
HHHHHHCCCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHEEECCEEEE
EPTETESKETLDEVASIYEKILEEARKEPDKLKEAPLTLTIKRLDEIKANKDLKVKFE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA