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The map label for this gene is gcvT [H]

Identifier: 160903341

GI number: 160903341

Start: 2116085

End: 2117410

Strand: Direct

Name: gcvT [H]

Synonym: Pmob_1912

Alternate gene names: 160903341

Gene position: 2116085-2117410 (Clockwise)

Preceding gene: 160903340

Following gene: 160903342

Centisome position: 97.54

GC content: 34.62

Gene sequence:

>1326_bases
ATGCTGAAAAAACTAAAAGATTACTGCAATTATTCACAGAGCCAGATTTTGAAACAAATTTTGGAAGAAAACGGTATACA
AGTATTTTTAAAATCTCCCATTGGAATAGGTGGAGAATATTTCGGTGAAGGAGCAATTTACGATTTATATGTTGAGGATA
AAGATTTTGAAAGCGCGATAGTTATAATTGAAGAATTGGAGAAGGGAGGAATTACTTTGTCTGAACTAAAAAAGACTCCG
CTTTATGAAAGACATATAGAACTTGGAGCGAAGTTGGGAGAATTTGCAGGTTGGGAGCTTCCGTTATGGTATTCTTCTAT
TATTGATGAGCATAACGCAGTAAGAAATTGTATTGGAGTTTTTGATGTATCTCATATGGGTGAATTATTTGTGCAAGGGA
AAGATGCTCAGAAATTTGTAAATTACCTTATTACAAATAATGTGGAAAAGATACCCATTGGTAAAATAGTGTACTCTCCT
ATGTGTAACGAGGATGGTGGAATTTTAGATGATCTTCTCGCTTATAAATTAGACGAAGAAAAGATCTTGTTGGTAGTCAA
CGCATCTAATACTCAAAAAGATTTTGATTGGGTAAGAAAGCAATCTTCTTCTTTTAATGTTGAGGTTATTAACAAGAGTG
ATGAATATTGCCAAATAGCTTTCCAAGGTCCTAAATCCCAGGATCAACTGCAAAAATATCTTAAAGATATTGATCTGGAT
AGTATAGAATATTATTCCTTCAAAATTCTAGGATTGGAAGGAGAAGAAGTAATATTATCAAGGACCGGATACACAGGTGA
AGATGGTTTTGAGTTGTACCTGTCTCCAGCGATCGCTGTTAAAGTTTGGGATAGACTTATACAACTTGCTAAAGAGGTTG
ATGGGAAACCATGTGGTTTAGGAAGCAGGGATACTTTGAGATTCGAGCCTAAAATGCTCCTTTATGGCAACGATATGGAT
GAAAATACTACTCCTTTGGAGGCAGGTCTAAGTTGGACTGTTGATTTTAATAAAGAATTTATTGGTAAGGAAGCTTTGCT
GAAACAAAAAGAAGAAGGAATCAAAAGAAAATTAGTTGGTATGGAAGTACACGACAAGATGCCCGTGAGACATGGGTATG
AAATTTTCAAAGATAATGAAAATATAGGGTTTGTGACAAGTGGTGTAAAGTCTCCTACTTTGGGGAAAAATTTAGCCTTA
GGCTATGTAAGTAAAGAATTTTCAAAATTAGAAACCATTGTGAGTATAAAAGCAAGGGAAAAGTTATTAGAAGCTGAGGT
CGTGAAAACTCCGTTTTATAAAGGAAGTGTAAAAAGCACAAAGTAA

Upstream 100 bases:

>100_bases
TTTAAACTCTTCTAATTAAAAATACTTCGACTTTCTAACTTTTTCAAAGAGTGATATAATTAAGGTTGAATAGTATCTTC
TCTCTGAGAGGTGTGAGACA

Downstream 100 bases:

>100_bases
AAATACGGGCAAAGGGGCGCTATATCAACTTTTATAAGAATAATAAAAAGAGGTGAGATGTTATAATGAATGATTTTCCA
TATTTACCCCATACCCAAAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MLKKLKDYCNYSQSQILKQILEENGIQVFLKSPIGIGGEYFGEGAIYDLYVEDKDFESAIVIIEELEKGGITLSELKKTP
LYERHIELGAKLGEFAGWELPLWYSSIIDEHNAVRNCIGVFDVSHMGELFVQGKDAQKFVNYLITNNVEKIPIGKIVYSP
MCNEDGGILDDLLAYKLDEEKILLVVNASNTQKDFDWVRKQSSSFNVEVINKSDEYCQIAFQGPKSQDQLQKYLKDIDLD
SIEYYSFKILGLEGEEVILSRTGYTGEDGFELYLSPAIAVKVWDRLIQLAKEVDGKPCGLGSRDTLRFEPKMLLYGNDMD
ENTTPLEAGLSWTVDFNKEFIGKEALLKQKEEGIKRKLVGMEVHDKMPVRHGYEIFKDNENIGFVTSGVKSPTLGKNLAL
GYVSKEFSKLETIVSIKAREKLLEAEVVKTPFYKGSVKSTK

Sequences:

>Translated_441_residues
MLKKLKDYCNYSQSQILKQILEENGIQVFLKSPIGIGGEYFGEGAIYDLYVEDKDFESAIVIIEELEKGGITLSELKKTP
LYERHIELGAKLGEFAGWELPLWYSSIIDEHNAVRNCIGVFDVSHMGELFVQGKDAQKFVNYLITNNVEKIPIGKIVYSP
MCNEDGGILDDLLAYKLDEEKILLVVNASNTQKDFDWVRKQSSSFNVEVINKSDEYCQIAFQGPKSQDQLQKYLKDIDLD
SIEYYSFKILGLEGEEVILSRTGYTGEDGFELYLSPAIAVKVWDRLIQLAKEVDGKPCGLGSRDTLRFEPKMLLYGNDMD
ENTTPLEAGLSWTVDFNKEFIGKEALLKQKEEGIKRKLVGMEVHDKMPVRHGYEIFKDNENIGFVTSGVKSPTLGKNLAL
GYVSKEFSKLETIVSIKAREKLLEAEVVKTPFYKGSVKSTK
>Mature_441_residues
MLKKLKDYCNYSQSQILKQILEENGIQVFLKSPIGIGGEYFGEGAIYDLYVEDKDFESAIVIIEELEKGGITLSELKKTP
LYERHIELGAKLGEFAGWELPLWYSSIIDEHNAVRNCIGVFDVSHMGELFVQGKDAQKFVNYLITNNVEKIPIGKIVYSP
MCNEDGGILDDLLAYKLDEEKILLVVNASNTQKDFDWVRKQSSSFNVEVINKSDEYCQIAFQGPKSQDQLQKYLKDIDLD
SIEYYSFKILGLEGEEVILSRTGYTGEDGFELYLSPAIAVKVWDRLIQLAKEVDGKPCGLGSRDTLRFEPKMLLYGNDMD
ENTTPLEAGLSWTVDFNKEFIGKEALLKQKEEGIKRKLVGMEVHDKMPVRHGYEIFKDNENIGFVTSGVKSPTLGKNLAL
GYVSKEFSKLETIVSIKAREKLLEAEVVKTPFYKGSVKSTK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=373, Percent_Identity=35.656836461126, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=35.195530726257, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI257796254, Length=366, Percent_Identity=31.6939890710383, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=34.0694006309148, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI24797151, Length=377, Percent_Identity=27.3209549071618, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI197927446, Length=410, Percent_Identity=24.1463414634146, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI21361378, Length=410, Percent_Identity=24.1463414634146, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI194306651, Length=394, Percent_Identity=24.3654822335025, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=38.8586956521739, Blast_Score=258, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=37.3333333333333, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32563613, Length=381, Percent_Identity=28.3464566929134, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71994045, Length=378, Percent_Identity=26.4550264550265, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=378, Percent_Identity=26.4550264550265, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=33.6760925449871, Blast_Score=183, Evalue=6e-47,
Organism=Drosophila melanogaster, GI20129441, Length=379, Percent_Identity=36.4116094986807, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI28571104, Length=385, Percent_Identity=29.3506493506493, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20130091, Length=404, Percent_Identity=24.5049504950495, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 49900; Mature: 49900

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKLKDYCNYSQSQILKQILEENGIQVFLKSPIGIGGEYFGEGAIYDLYVEDKDFESAI
CCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCEEEEEECCCCCCHHE
VIIEELEKGGITLSELKKTPLYERHIELGAKLGEFAGWELPLWYSSIIDEHNAVRNCIGV
EEEEHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FDVSHMGELFVQGKDAQKFVNYLITNNVEKIPIGKIVYSPMCNEDGGILDDLLAYKLDEE
HCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCC
KILLVVNASNTQKDFDWVRKQSSSFNVEVINKSDEYCQIAFQGPKSQDQLQKYLKDIDLD
EEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
SIEYYSFKILGLEGEEVILSRTGYTGEDGFELYLSPAIAVKVWDRLIQLAKEVDGKPCGL
CEEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCC
GSRDTLRFEPKMLLYGNDMDENTTPLEAGLSWTVDFNKEFIGKEALLKQKEEGIKRKLVG
CCCCCEEECCEEEEECCCCCCCCCCHHCCCEEEEECCHHHHCHHHHHHHHHHHHHHHHCC
MEVHDKMPVRHGYEIFKDNENIGFVTSGVKSPTLGKNLALGYVSKEFSKLETIVSIKARE
CCHHCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
KLLEAEVVKTPFYKGSVKSTK
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLKKLKDYCNYSQSQILKQILEENGIQVFLKSPIGIGGEYFGEGAIYDLYVEDKDFESAI
CCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCEEEEEECCCCCCHHE
VIIEELEKGGITLSELKKTPLYERHIELGAKLGEFAGWELPLWYSSIIDEHNAVRNCIGV
EEEEHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FDVSHMGELFVQGKDAQKFVNYLITNNVEKIPIGKIVYSPMCNEDGGILDDLLAYKLDEE
HCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCC
KILLVVNASNTQKDFDWVRKQSSSFNVEVINKSDEYCQIAFQGPKSQDQLQKYLKDIDLD
EEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
SIEYYSFKILGLEGEEVILSRTGYTGEDGFELYLSPAIAVKVWDRLIQLAKEVDGKPCGL
CEEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCC
GSRDTLRFEPKMLLYGNDMDENTTPLEAGLSWTVDFNKEFIGKEALLKQKEEGIKRKLVG
CCCCCEEECCEEEEECCCCCCCCCCHHCCCEEEEECCHHHHCHHHHHHHHHHHHHHHHCC
MEVHDKMPVRHGYEIFKDNENIGFVTSGVKSPTLGKNLALGYVSKEFSKLETIVSIKARE
CCHHCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
KLLEAEVVKTPFYKGSVKSTK
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA