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The map label for this gene is guaB [H]

Identifier: 160903333

GI number: 160903333

Start: 2109333

End: 2110784

Strand: Direct

Name: guaB [H]

Synonym: Pmob_1904

Alternate gene names: 160903333

Gene position: 2109333-2110784 (Clockwise)

Preceding gene: 160903332

Following gene: 160903334

Centisome position: 97.22

GC content: 37.6

Gene sequence:

>1452_bases
ATGGAAGAGTATCTAACTTTTGATGATGTGTTACTACTACCGCAGTATAGCGAAGTTGTACCGAGCAGGGTTGATACTAC
ATCTTGTTTAGTAAAAAATATCCATTTAAAGATCCCTTTTCTTTCTGCAGCTATGGATACTGTGACTGAATCCCAAATGG
CAAAAGCTATGGCAAGAGAAGGTGCCGTTGGTGTTATTCATAAAAATATGTCGATTGAACAGCAAGCCTATGAGGTTTCA
AAGGTAAAAAAGACAGAGAACGGGATTATATACGATCCCATAACAATTACGCCCGATACAACCGTTAAAGAAGCTGAAAA
GATCATGAGAGAGTACAGAATTGGTGGATTACCAGTTGTGGATGATGATAAAGTTCTTTTGGGTATATTGACCAACAGAG
ATATTAGGTTTGAACAAAATATGGAAAAGAAAGCTAAAGAATTGATGACTCCCTACCAAAATTTAGTTGTAGCTGGTTCA
CATATTTCTTTGGAAGAGGCAAAAGAGATACTTCATCAAAATAAAATAGAGAAATTGCCTATAGTAGATGATAAAAGACA
TATAAAGGGTTTGATAACGATAAAAGATATTACTTCCGTAATCGAAAACCCAAACGCAACACGAGATGATAAAGGGCGTT
TAGTTGTTGGAGCTGCTGTTGGTGTTTCAGAGGGTTTACAAAGAACGCAAGAATTAGTTGATGCAGGAGTCGATTTTGTA
GTTTTAGATTCAGCCCATGGACATTCCAAAAATATTATTGAGACATTAAAAAAGATAAAAGAAAGATTCCCGGAACTCCC
TGTAATTGCTGGAAATATAGCTACTGCTGAAGCTGCCAAGATGTTAATAGAAAGCGGAGCAGATGCAGTAAAAGTTGGAA
TTGGGCCAGGTTCTATTTGTACCACCAGAGTTATTTCCGGTGTTGGGGTACCACAGTTAAGTGCAATTATGAAAGTTTCA
GAAGAAGCGAATAAATACAATATCCCTGTTATTGCAGATGGTGGGATAAGATATTCTGGAGATATCGTCAAAGCTTTAGC
TGCAGGAGCCTCTACCGTGATGATGGGAAGTATTTTTGCAGGTACTGAAGAGGCACCGGGTGAAACGATAATTTATCAAG
GTAGGAAGTTTAAAACATACAGAGGCATGGGTTCGATAGCAGCTATGGAAAAAGGGAGCAAAGATAGATATTTCCAAGAA
AGTACACCAAATGAGAAACTTGTGCCAGAGGGTGTTGAAGCTATGGTAGCATACAAAGGTGAGGTAAAAGATGTTATAAT
ACAATTAGTTGGAGGAGTCAAAGCTGGAATGGGGTATGTTGGGGCAAAAGATATCAAGGAATTACAGCAAAAGGCTAAAT
TTATAAAAATTACAACCGCAAGTATAACAGAAAGTCATCCACATGATGTAAAGATTACACGTGAAGCTCCGAATTATTTC
TTTTCATCTTAG

Upstream 100 bases:

>100_bases
AATTAAATAATTTTAAATGGGTTACAGGGCAGGGCCCCGGCTAAGGGGCGCTAAAAACGTTTTTTTACGATAATATTCAC
CACGGCAAGGAGGCAGAGAA

Downstream 100 bases:

>100_bases
TTATTGATTTATGACGTATAATAGGCTGATCTTTCACCTACTTAAAGGGGTGGGCTGGCAGGGTCAAGGGATAAAAATTC
TTTTATCCTTATGGGTGGGG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MEEYLTFDDVLLLPQYSEVVPSRVDTTSCLVKNIHLKIPFLSAAMDTVTESQMAKAMAREGAVGVIHKNMSIEQQAYEVS
KVKKTENGIIYDPITITPDTTVKEAEKIMREYRIGGLPVVDDDKVLLGILTNRDIRFEQNMEKKAKELMTPYQNLVVAGS
HISLEEAKEILHQNKIEKLPIVDDKRHIKGLITIKDITSVIENPNATRDDKGRLVVGAAVGVSEGLQRTQELVDAGVDFV
VLDSAHGHSKNIIETLKKIKERFPELPVIAGNIATAEAAKMLIESGADAVKVGIGPGSICTTRVISGVGVPQLSAIMKVS
EEANKYNIPVIADGGIRYSGDIVKALAAGASTVMMGSIFAGTEEAPGETIIYQGRKFKTYRGMGSIAAMEKGSKDRYFQE
STPNEKLVPEGVEAMVAYKGEVKDVIIQLVGGVKAGMGYVGAKDIKELQQKAKFIKITTASITESHPHDVKITREAPNYF
FSS

Sequences:

>Translated_483_residues
MEEYLTFDDVLLLPQYSEVVPSRVDTTSCLVKNIHLKIPFLSAAMDTVTESQMAKAMAREGAVGVIHKNMSIEQQAYEVS
KVKKTENGIIYDPITITPDTTVKEAEKIMREYRIGGLPVVDDDKVLLGILTNRDIRFEQNMEKKAKELMTPYQNLVVAGS
HISLEEAKEILHQNKIEKLPIVDDKRHIKGLITIKDITSVIENPNATRDDKGRLVVGAAVGVSEGLQRTQELVDAGVDFV
VLDSAHGHSKNIIETLKKIKERFPELPVIAGNIATAEAAKMLIESGADAVKVGIGPGSICTTRVISGVGVPQLSAIMKVS
EEANKYNIPVIADGGIRYSGDIVKALAAGASTVMMGSIFAGTEEAPGETIIYQGRKFKTYRGMGSIAAMEKGSKDRYFQE
STPNEKLVPEGVEAMVAYKGEVKDVIIQLVGGVKAGMGYVGAKDIKELQQKAKFIKITTASITESHPHDVKITREAPNYF
FSS
>Mature_483_residues
MEEYLTFDDVLLLPQYSEVVPSRVDTTSCLVKNIHLKIPFLSAAMDTVTESQMAKAMAREGAVGVIHKNMSIEQQAYEVS
KVKKTENGIIYDPITITPDTTVKEAEKIMREYRIGGLPVVDDDKVLLGILTNRDIRFEQNMEKKAKELMTPYQNLVVAGS
HISLEEAKEILHQNKIEKLPIVDDKRHIKGLITIKDITSVIENPNATRDDKGRLVVGAAVGVSEGLQRTQELVDAGVDFV
VLDSAHGHSKNIIETLKKIKERFPELPVIAGNIATAEAAKMLIESGADAVKVGIGPGSICTTRVISGVGVPQLSAIMKVS
EEANKYNIPVIADGGIRYSGDIVKALAAGASTVMMGSIFAGTEEAPGETIIYQGRKFKTYRGMGSIAAMEKGSKDRYFQE
STPNEKLVPEGVEAMVAYKGEVKDVIIQLVGGVKAGMGYVGAKDIKELQQKAKFIKITTASITESHPHDVKITREAPNYF
FSS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=42.7974947807933, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI217035146, Length=477, Percent_Identity=41.9287211740042, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI156616279, Length=477, Percent_Identity=41.9287211740042, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI34328930, Length=477, Percent_Identity=41.9287211740042, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI34328928, Length=477, Percent_Identity=41.9287211740042, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI217035152, Length=481, Percent_Identity=41.3721413721414, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI217035148, Length=477, Percent_Identity=41.0901467505241, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035150, Length=477, Percent_Identity=39.2033542976939, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI156104880, Length=222, Percent_Identity=42.3423423423423, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI50541954, Length=259, Percent_Identity=38.2239382239382, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI50541952, Length=259, Percent_Identity=38.2239382239382, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI50541948, Length=259, Percent_Identity=38.2239382239382, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI50541956, Length=259, Percent_Identity=38.2239382239382, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=50.3080082135524, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1786293, Length=234, Percent_Identity=36.7521367521368, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=497, Percent_Identity=36.4185110663984, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=38.5714285714286, Blast_Score=264, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17560440, Length=220, Percent_Identity=40.9090909090909, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322012, Length=482, Percent_Identity=40.0414937759336, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=41.5217391304348, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=41.0788381742739, Blast_Score=325, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.6449704142012, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=41.8032786885246, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=41.5800415800416, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=41.5800415800416, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.7233560090703, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52606; Mature: 52606

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEYLTFDDVLLLPQYSEVVPSRVDTTSCLVKNIHLKIPFLSAAMDTVTESQMAKAMARE
CCCCCCCCCEEECCCHHHHCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHC
GAVGVIHKNMSIEQQAYEVSKVKKTENGIIYDPITITPDTTVKEAEKIMREYRIGGLPVV
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCEEECCCCCHHHHHHHHHHHCCCCCCEE
DDDKVLLGILTNRDIRFEQNMEKKAKELMTPYQNLVVAGSHISLEEAKEILHQNKIEKLP
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHCCCCCCC
IVDDKRHIKGLITIKDITSVIENPNATRDDKGRLVVGAAVGVSEGLQRTQELVDAGVDFV
CCCCCHHHEEEEEHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEE
VLDSAHGHSKNIIETLKKIKERFPELPVIAGNIATAEAAKMLIESGADAVKVGIGPGSIC
EEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRVISGVGVPQLSAIMKVSEEANKYNIPVIADGGIRYSGDIVKALAAGASTVMMGSIFA
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEECHHHHHHHHCCCHHHHHHHHCC
GTEEAPGETIIYQGRKFKTYRGMGSIAAMEKGSKDRYFQESTPNEKLVPEGVEAMVAYKG
CCCCCCCCEEEECCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
EVKDVIIQLVGGVKAGMGYVGAKDIKELQQKAKFIKITTASITESHPHDVKITREAPNYF
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCCCC
FSS
CCC
>Mature Secondary Structure
MEEYLTFDDVLLLPQYSEVVPSRVDTTSCLVKNIHLKIPFLSAAMDTVTESQMAKAMARE
CCCCCCCCCEEECCCHHHHCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHC
GAVGVIHKNMSIEQQAYEVSKVKKTENGIIYDPITITPDTTVKEAEKIMREYRIGGLPVV
CCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCEEECCCCCHHHHHHHHHHHCCCCCCEE
DDDKVLLGILTNRDIRFEQNMEKKAKELMTPYQNLVVAGSHISLEEAKEILHQNKIEKLP
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHCCCCCCC
IVDDKRHIKGLITIKDITSVIENPNATRDDKGRLVVGAAVGVSEGLQRTQELVDAGVDFV
CCCCCHHHEEEEEHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEE
VLDSAHGHSKNIIETLKKIKERFPELPVIAGNIATAEAAKMLIESGADAVKVGIGPGSIC
EEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRVISGVGVPQLSAIMKVSEEANKYNIPVIADGGIRYSGDIVKALAAGASTVMMGSIFA
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEECHHHHHHHHCCCHHHHHHHHCC
GTEEAPGETIIYQGRKFKTYRGMGSIAAMEKGSKDRYFQESTPNEKLVPEGVEAMVAYKG
CCCCCCCCEEEECCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
EVKDVIIQLVGGVKAGMGYVGAKDIKELQQKAKFIKITTASITESHPHDVKITREAPNYF
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCCCC
FSS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]