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The map label for this gene is folD

Identifier: 160903189

GI number: 160903189

Start: 1923027

End: 1923848

Strand: Direct

Name: folD

Synonym: Pmob_1757

Alternate gene names: 160903189

Gene position: 1923027-1923848 (Clockwise)

Preceding gene: 160903188

Following gene: 160903190

Centisome position: 88.64

GC content: 34.06

Gene sequence:

>822_bases
ATGTTAATTGAAGTAGACAATATTATTGATGAAATAAAGGCAGAAATATCATCACTTAAAGAAAAAGTTCCTTATGAACC
CAAATTAGTAAGTTTAGTTGTTGAACCCGATGAATCTACCAAATCTTATCTTAACTCTCAAAAAAGAAATGCAAAAAAAT
TTGGAATCAACTTAGAAATTGTTGAAAGTAATGATTTGACTAACGATTTAAGAAAATATAATGAAGACGATGATACTGAT
GCAATCTTTATTGCAAGACCTTTAAAGAAAGGATACACTGAATTAGATATAGCAAAATATATCAATCCAGAAAAAGATGT
TGAAGGGGTAAGTTTACATAACATCGGTTCTATGTTTTACGAAAAAGAATTGTTTGTACCTTGTACAGCAGAAGCGGTGG
TGAAAATAATAGAAGATACAACTGACGTTAGAGGTAAAAATATCGTTATCCTTGGAAGAAGTACAACGGTAGGGAAACCC
GCTGCAATAATGCTTCAAAGACACGGAAGGGATGCCACTGTCACGGTCACACATACAAAAACTAAGAACTTAAAAGAGAT
AACCAAAGAAGCAGACATCTTGGTTGCAGCAATAGGTAAGGCTAATTTCGTTGATAGTACTTTTGTAAAAGAAGGAATGA
TCGTGATCGATGTGGGAATAAATGTAGTGGATGGAAAAATAGTGGGTGATGTAAATAAAGATGTCTCAGAAATATGCCAG
TTAACACCTGTACCCGGTGGTGTTGGAAGCGTCACAACAGCTATTCTAATGAGAAATGTTTTTAGAGCGGCTAACAATAA
AAAGGGAGATATGCAACTTTGA

Upstream 100 bases:

>100_bases
AAGGTTCCCAATGCAGTGAATATGGACATAGACAATGAAGGAAACATATCCGGATTGTCATGAGCACGGTGAATAAATTG
AATTTGGGGGGTATCACATT

Downstream 100 bases:

>100_bases
AGAATAATTTCAACGAAATTGTGGACAGAAAATCTACAGAGTCAGTAAAATGGAACGGTGTCAAAAGTCTTTATGGTAGA
GATGATGTTATCCCCATGTG

Product: tetrahydrofolate dehydrogenase/cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVESNDLTNDLRKYNEDDDTD
AIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKP
AAIMLQRHGRDATVTVTHTKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQ
LTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL

Sequences:

>Translated_273_residues
MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVESNDLTNDLRKYNEDDDTD
AIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKP
AAIMLQRHGRDATVTVTHTKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQ
LTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL
>Mature_273_residues
MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEIVESNDLTNDLRKYNEDDDTD
AIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKP
AAIMLQRHGRDATVTVTHTKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQ
LTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=281, Percent_Identity=35.9430604982206, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI94721354, Length=284, Percent_Identity=35.9154929577465, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI222136639, Length=274, Percent_Identity=33.5766423357664, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1786741, Length=248, Percent_Identity=34.2741935483871, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17568735, Length=285, Percent_Identity=35.4385964912281, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319558, Length=275, Percent_Identity=36.3636363636364, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321643, Length=285, Percent_Identity=32.6315789473684, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322933, Length=286, Percent_Identity=23.4265734265734, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24645718, Length=284, Percent_Identity=37.3239436619718, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17137370, Length=284, Percent_Identity=37.3239436619718, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI62472483, Length=284, Percent_Identity=37.3239436619718, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45551871, Length=284, Percent_Identity=37.3239436619718, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17136816, Length=283, Percent_Identity=31.095406360424, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136818, Length=283, Percent_Identity=31.095406360424, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PETMO (A9BIV9)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568770.1
- ProteinModelPortal:   A9BIV9
- SMR:   A9BIV9
- GeneID:   5757471
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1757
- HOGENOM:   HBG328751
- OMA:   VESLHAR
- ProtClustDB:   CLSK875961
- BioCyc:   PMOB403833:PMOB_1757-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30051; Mature: 30051

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEI
CEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHCCEEEE
VESNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFY
EECCCCHHHHHHCCCCCCCCEEEEEECHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
EKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTHTK
HCCEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECC
TKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQ
CCHHHHHHHHHCEEEEECCCCCCCCHHHHHCCEEEEEECCEEECCEEEECCCCCHHHHHH
LTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLIEVDNIIDEIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGINLEI
CEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHCCEEEE
VESNDLTNDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFY
EECCCCHHHHHHCCCCCCCCEEEEEECHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
EKELFVPCTAEAVVKIIEDTTDVRGKNIVILGRSTTVGKPAAIMLQRHGRDATVTVTHTK
HCCEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECC
TKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVVDGKIVGDVNKDVSEICQ
CCHHHHHHHHHCEEEEECCCCCCCCHHHHHCCEEEEEECCEEECCEEEECCCCCHHHHHH
LTPVPGGVGSVTTAILMRNVFRAANNKKGDMQL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA