Click here to switch to the map view.

The map label for this gene is fhs

Identifier: 160903188

GI number: 160903188

Start: 1921325

End: 1922989

Strand: Direct

Name: fhs

Synonym: Pmob_1756

Alternate gene names: 160903188

Gene position: 1921325-1922989 (Clockwise)

Preceding gene: 160903187

Following gene: 160903189

Centisome position: 88.56

GC content: 35.62

Gene sequence:

>1665_bases
ATGCTTTCTGATATCGAAATTGCAAGATCTGCAAAGCTAAAAAAAATTGATTTAATCGCAAACGAGCTGGATATTCCAGA
GGAGTACTACAATCTTTACGGAAAGAACATTGCCAAAGTTTCCCACAAATATTTGAATGAACTTAACTTCAAAAATGACG
GTAATTTAGTAATGGTAACTGCTATTACTCCAACGCCTGCTGGTGAAGGAAAAACTACAACAAGTATTTCACTATCCATG
GCTTTAAACAAAATCCACAAAAGGTCAATAGTAACTCTAAGAGAACCTTCTTTGGGTCCAGTAATGGGTATAAAAGGGGG
AGCAGCAGGTGGAGGCTACTCTCAAGTACTTCCTATGGAAGACATAAACTTACATTTCACAGGAGACATTCATGCCGTTA
CCTCAGCCCATAACCTAATATCAGCAATTTTAGATGATTACATAAAGTACAATAAATATGATATAGATTCAACCCAAGTC
TCTTGGCCTCGAACTATGGACATGAACGATAGGGCTTTGAGAGAAATAATAGTTGCGTTGGGTGGAAAGAAAAACGGTTA
TCCCAGACAAGACGGTTTTATAATCACCGCTGCTTCAGAAATAATGGCAATACTATGTTTGATAGAAAATTTGGAAGACT
TAAAGAAAAAATTATCTAATATAGTAGTTGCTAAAAATAAAAAGGGAGAACCAGTAACTGTAAAAGATTTAGAAATCACT
GGGGCTCTTTCTGTACTCTTAAAAGACGCAATTAATCCTAATTTAGTTCAAACAATTGAAAATACACCTGCCTTTGTTCA
TGGTGGGCCTTTTGCAAATATCGCTCATGGAACCAATTCTATTTTAGCAACAAAACTTGCCTTGAAGCTTTCTGATTACG
TTGTAACCGAAACAGGTTTTGGTTCTGATTTGGGAGGAGAAAAATTCTATGATTTTGTTTCTCCAACTTTTGGCTTAAAA
CCATCAGCTACGGTTTTGGTAGCTACAATACGGGCTTTAAAATACCATGGGGGACAAAACTTAAAGGATTTGAATACGCC
AAACCTTGAAAGTTTAGAAAAAGGATTGCCTAACTTACAGGTTCACGTTGAAAACCTAAAAAAGTACAATATTCCTGTGG
TTGTTTCTTTAAATAAATTTTACTCAGATACGGATGAAGAAATCAATATGGTAAAAGATTATTGTGATAAATTAGGTGTA
GAAGTAAGTGTCAACGAAGGATTTGAGAAAGGTTCAGAAGGTGCTATAGACTTAGCTGAAAAAGTGGTAAAAGTTAGTGA
ACAACAATCCGAATTGAAAAGTATTTACGATTTTAAAGATCCTTTAGAAGTGAAAATAGAAAAGTTAGCAAAAAATATCT
ATCGTGCTTCCAAGGTTGAATATTCTTCGGAGGCCTTATCAACAATTAAATTTTTGAAAAAATACGGATACGAAAATCTC
CCTGTAATTGTAGCAAAAACCCAGTATTCTATATCCGACGATCCTAAAAAACTTGGATTTCCAAAGGACTATACTTTCAC
AATACGAGATTTTGAACTTTCGGCGGGCGCAGGGTTCATTGTTGCATTGGCTGGAGATATATTGAGAATGCCTGGCCTTT
CAAAGGTTCCCAATGCAGTGAATATGGACATAGACAATGAAGGAAACATATCCGGATTGTCATGA

Upstream 100 bases:

>100_bases
TTATTTTAAAAGAAAATAGTTGTTTGTTTATGCATATATTGTATTATCAAATATCATAGAAGACTGTATTTCAAAATAAT
TAAAAAGGAGGAGTTTTACA

Downstream 100 bases:

>100_bases
GCACGGTGAATAAATTGAATTTGGGGGGTATCACATTATGTTAATTGAAGTAGACAATATTATTGATGAAATAAAGGCAG
AAATATCATCACTTAAAGAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MLSDIEIARSAKLKKIDLIANELDIPEEYYNLYGKNIAKVSHKYLNELNFKNDGNLVMVTAITPTPAGEGKTTTSISLSM
ALNKIHKRSIVTLREPSLGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVTSAHNLISAILDDYIKYNKYDIDSTQV
SWPRTMDMNDRALREIIVALGGKKNGYPRQDGFIITAASEIMAILCLIENLEDLKKKLSNIVVAKNKKGEPVTVKDLEIT
GALSVLLKDAINPNLVQTIENTPAFVHGGPFANIAHGTNSILATKLALKLSDYVVTETGFGSDLGGEKFYDFVSPTFGLK
PSATVLVATIRALKYHGGQNLKDLNTPNLESLEKGLPNLQVHVENLKKYNIPVVVSLNKFYSDTDEEINMVKDYCDKLGV
EVSVNEGFEKGSEGAIDLAEKVVKVSEQQSELKSIYDFKDPLEVKIEKLAKNIYRASKVEYSSEALSTIKFLKKYGYENL
PVIVAKTQYSISDDPKKLGFPKDYTFTIRDFELSAGAGFIVALAGDILRMPGLSKVPNAVNMDIDNEGNISGLS

Sequences:

>Translated_554_residues
MLSDIEIARSAKLKKIDLIANELDIPEEYYNLYGKNIAKVSHKYLNELNFKNDGNLVMVTAITPTPAGEGKTTTSISLSM
ALNKIHKRSIVTLREPSLGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVTSAHNLISAILDDYIKYNKYDIDSTQV
SWPRTMDMNDRALREIIVALGGKKNGYPRQDGFIITAASEIMAILCLIENLEDLKKKLSNIVVAKNKKGEPVTVKDLEIT
GALSVLLKDAINPNLVQTIENTPAFVHGGPFANIAHGTNSILATKLALKLSDYVVTETGFGSDLGGEKFYDFVSPTFGLK
PSATVLVATIRALKYHGGQNLKDLNTPNLESLEKGLPNLQVHVENLKKYNIPVVVSLNKFYSDTDEEINMVKDYCDKLGV
EVSVNEGFEKGSEGAIDLAEKVVKVSEQQSELKSIYDFKDPLEVKIEKLAKNIYRASKVEYSSEALSTIKFLKKYGYENL
PVIVAKTQYSISDDPKKLGFPKDYTFTIRDFELSAGAGFIVALAGDILRMPGLSKVPNAVNMDIDNEGNISGLS
>Mature_554_residues
MLSDIEIARSAKLKKIDLIANELDIPEEYYNLYGKNIAKVSHKYLNELNFKNDGNLVMVTAITPTPAGEGKTTTSISLSM
ALNKIHKRSIVTLREPSLGPVMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAVTSAHNLISAILDDYIKYNKYDIDSTQV
SWPRTMDMNDRALREIIVALGGKKNGYPRQDGFIITAASEIMAILCLIENLEDLKKKLSNIVVAKNKKGEPVTVKDLEIT
GALSVLLKDAINPNLVQTIENTPAFVHGGPFANIAHGTNSILATKLALKLSDYVVTETGFGSDLGGEKFYDFVSPTFGLK
PSATVLVATIRALKYHGGQNLKDLNTPNLESLEKGLPNLQVHVENLKKYNIPVVVSLNKFYSDTDEEINMVKDYCDKLGV
EVSVNEGFEKGSEGAIDLAEKVVKVSEQQSELKSIYDFKDPLEVKIEKLAKNIYRASKVEYSSEALSTIKFLKKYGYENL
PVIVAKTQYSISDDPKKLGFPKDYTFTIRDFELSAGAGFIVALAGDILRMPGLSKVPNAVNMDIDNEGNISGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=610, Percent_Identity=41.8032786885246, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI36796743, Length=610, Percent_Identity=41.3114754098361, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17568737, Length=612, Percent_Identity=41.8300653594771, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568739, Length=612, Percent_Identity=41.8300653594771, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321643, Length=624, Percent_Identity=39.5833333333333, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=38.9507154213037, Blast_Score=412, Evalue=1e-116,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=42.9497568881686, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=42.9497568881686, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=42.9497568881686, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=42.9497568881686, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_PETMO (A9BIV8)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568769.1
- ProteinModelPortal:   A9BIV8
- SMR:   A9BIV8
- GeneID:   5757754
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1756
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- ProtClustDB:   PRK13505
- BioCyc:   PMOB403833:PMOB_1756-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60679; Mature: 60679

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDIEIARSAKLKKIDLIANELDIPEEYYNLYGKNIAKVSHKYLNELNFKNDGNLVMVT
CCCCHHHHHCCCCEEEEHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEE
AITPTPAGEGKTTTSISLSMALNKIHKRSIVTLREPSLGPVMGIKGGAAGGGYSQVLPME
EECCCCCCCCCCEEEEEHHHHHHHHHHHCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
DINLHFTGDIHAVTSAHNLISAILDDYIKYNKYDIDSTQVSWPRTMDMNDRALREIIVAL
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GGKKNGYPRQDGFIITAASEIMAILCLIENLEDLKKKLSNIVVAKNKKGEPVTVKDLEIT
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEHH
GALSVLLKDAINPNLVQTIENTPAFVHGGPFANIAHGTNSILATKLALKLSDYVVTETGF
HHHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCC
GSDLGGEKFYDFVSPTFGLKPSATVLVATIRALKYHGGQNLKDLNTPNLESLEKGLPNLQ
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCEE
VHVENLKKYNIPVVVSLNKFYSDTDEEINMVKDYCDKLGVEVSVNEGFEKGSEGAIDLAE
EEEEHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHH
KVVKVSEQQSELKSIYDFKDPLEVKIEKLAKNIYRASKVEYSSEALSTIKFLKKYGYENL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PVIVAKTQYSISDDPKKLGFPKDYTFTIRDFELSAGAGFIVALAGDILRMPGLSKVPNAV
CEEEEEEEECCCCCHHHCCCCCCCEEEEEEEEECCCCCEEEEEHHHHHHCCCCCCCCCCE
NMDIDNEGNISGLS
EECCCCCCCCCCCC
>Mature Secondary Structure
MLSDIEIARSAKLKKIDLIANELDIPEEYYNLYGKNIAKVSHKYLNELNFKNDGNLVMVT
CCCCHHHHHCCCCEEEEHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEE
AITPTPAGEGKTTTSISLSMALNKIHKRSIVTLREPSLGPVMGIKGGAAGGGYSQVLPME
EECCCCCCCCCCEEEEEHHHHHHHHHHHCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
DINLHFTGDIHAVTSAHNLISAILDDYIKYNKYDIDSTQVSWPRTMDMNDRALREIIVAL
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GGKKNGYPRQDGFIITAASEIMAILCLIENLEDLKKKLSNIVVAKNKKGEPVTVKDLEIT
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEHH
GALSVLLKDAINPNLVQTIENTPAFVHGGPFANIAHGTNSILATKLALKLSDYVVTETGF
HHHHHHHHHCCCCHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCC
GSDLGGEKFYDFVSPTFGLKPSATVLVATIRALKYHGGQNLKDLNTPNLESLEKGLPNLQ
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCEE
VHVENLKKYNIPVVVSLNKFYSDTDEEINMVKDYCDKLGVEVSVNEGFEKGSEGAIDLAE
EEEEHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHH
KVVKVSEQQSELKSIYDFKDPLEVKIEKLAKNIYRASKVEYSSEALSTIKFLKKYGYENL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PVIVAKTQYSISDDPKKLGFPKDYTFTIRDFELSAGAGFIVALAGDILRMPGLSKVPNAV
CEEEEEEEECCCCCHHHCCCCCCCEEEEEEEEECCCCCEEEEEHHHHHHCCCCCCCCCCE
NMDIDNEGNISGLS
EECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA