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The map label for this gene is ygeZ [C]

Identifier: 160903165

GI number: 160903165

Start: 1894565

End: 1895920

Strand: Direct

Name: ygeZ [C]

Synonym: Pmob_1730

Alternate gene names: 160903165

Gene position: 1894565-1895920 (Clockwise)

Preceding gene: 160903164

Following gene: 160903166

Centisome position: 87.33

GC content: 32.82

Gene sequence:

>1356_bases
GTGTTAATCAAAAACGGTATCGTAGTTACTGCCACAAAAACTGAAAAAAAAGACATTAGAATATTGGACGAAAAGATAAA
ACAAATAGAATCTAACTTAACTCCTTTTATGGATGAAGAGGTAATAGATGCAAGCGGAAAGTATGTTTTCCCTGGAATTA
TAGATAGTCATACTCATTTTAGTTTGCACGCTAGAGGTACAACCAGTATAGATGACTTCTACTGGGGAGGGCGATCAGCT
GCTTTAGGTGGAGTAACTACACACATAGATTTTGCTGATATGGAAGCTACGTCTTTGATGAAAGGATTAGAAAATAGATT
AGAAGAAACTAGAGATTCCGTGATTGATTTTCATTTTCATATAGTTATTAACAACAACTTCAACCCACTTAAGCAAAATC
ATCAGCTTAGAGAGATTAGAGATTTTGGAATATCTAGTTTAAAAGCATTCACTACCTACAAAAATATATATATGCTGTCT
TCTGACAAATGGGAACCTTTATTTAAGGCAGCTGGAGATAATGACTTAATAGTAGCTGTTCATGCTGAAGATAATGAAAT
TATCGAAAAAAATATTGTGAAATTCCAAAAAGAAAATAAATTAGATGCTCAATATCATCCAGATATTAGACCAAGTGAAG
CTGAGCAAAAGGCAGTTAAAAAAATTTGTGAGATTGCTCATAAAACTAATGCTTCGCTATACATAGTACATCTTTCATCT
GAAAAAGGTTATCAGGTAGTTAAAGAGTATAAAAATCTAAAAAATTTTAAATTGTATGTTGAAACCACACCTCACTATCT
CTTATTAACAAGAGAATTATTAAAAGGTCCTAAAGCCAGTTTTTATTTTATGACTCCTCCATTGAGAGAAAGTCAAGATA
ACGAAGCTTTGTGGGAAGGAATTCAAAAAGGCTTGATAGACGTAATTGCCACAGACCACTGCGCTTACAATGCAGAGCAA
AAATCAATGGGTAAAAATTCATTGGATATATTTCCTGGTATTCCTGGAGTGGAAACACTTCTTGCTTTGACATATACATA
TGGGGTAAATAAAGGTTTAATTTCTATAAACAGGTTGGTTGAACTCCTTTCCACTAATCCAGCAAAAATTTTCAAACTGT
ATCCACAAAAAGGAACAATAGCTATAGATTCTGACGCTGATTTAGTTATTTTCGATCCAAATTTAAAGGAAGTATTAAAT
AGTTCTAACACTCATTCGAAGGCAGCATACACTCCTTTTGAAGGATTTGAAGTGGAAGGACTTCCCATAACAACCATTTT
AAGAGGAAAAGTAATCGTAAAAGATAGAAATTTCCTAGGAGAAAAAGGTTTTGGAAGGTTTATAAAAGCTATATAA

Upstream 100 bases:

>100_bases
ACGAAAAAACATGGAAAAGTGAATTGGTGAAGGCCGCTGCAATGTATGCATGCATACCTAAGTTGTATACTCAAAAATAC
TTGTAAAAGGAAGGATTACG

Downstream 100 bases:

>100_bases
TTATATTGGAGGAGATAAGATGAATACACTTTTTAGGGGAAAGGATTTTATAACTACACAAGAATGGAGTAAAGAAGAAT
TAGAAACTGTTTTTGAATTA

Product: dihydropyrimidinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLIKNGIVVTATKTEKKDIRILDEKIKQIESNLTPFMDEEVIDASGKYVFPGIIDSHTHFSLHARGTTSIDDFYWGGRSA
ALGGVTTHIDFADMEATSLMKGLENRLEETRDSVIDFHFHIVINNNFNPLKQNHQLREIRDFGISSLKAFTTYKNIYMLS
SDKWEPLFKAAGDNDLIVAVHAEDNEIIEKNIVKFQKENKLDAQYHPDIRPSEAEQKAVKKICEIAHKTNASLYIVHLSS
EKGYQVVKEYKNLKNFKLYVETTPHYLLLTRELLKGPKASFYFMTPPLRESQDNEALWEGIQKGLIDVIATDHCAYNAEQ
KSMGKNSLDIFPGIPGVETLLALTYTYGVNKGLISINRLVELLSTNPAKIFKLYPQKGTIAIDSDADLVIFDPNLKEVLN
SSNTHSKAAYTPFEGFEVEGLPITTILRGKVIVKDRNFLGEKGFGRFIKAI

Sequences:

>Translated_451_residues
MLIKNGIVVTATKTEKKDIRILDEKIKQIESNLTPFMDEEVIDASGKYVFPGIIDSHTHFSLHARGTTSIDDFYWGGRSA
ALGGVTTHIDFADMEATSLMKGLENRLEETRDSVIDFHFHIVINNNFNPLKQNHQLREIRDFGISSLKAFTTYKNIYMLS
SDKWEPLFKAAGDNDLIVAVHAEDNEIIEKNIVKFQKENKLDAQYHPDIRPSEAEQKAVKKICEIAHKTNASLYIVHLSS
EKGYQVVKEYKNLKNFKLYVETTPHYLLLTRELLKGPKASFYFMTPPLRESQDNEALWEGIQKGLIDVIATDHCAYNAEQ
KSMGKNSLDIFPGIPGVETLLALTYTYGVNKGLISINRLVELLSTNPAKIFKLYPQKGTIAIDSDADLVIFDPNLKEVLN
SSNTHSKAAYTPFEGFEVEGLPITTILRGKVIVKDRNFLGEKGFGRFIKAI
>Mature_451_residues
MLIKNGIVVTATKTEKKDIRILDEKIKQIESNLTPFMDEEVIDASGKYVFPGIIDSHTHFSLHARGTTSIDDFYWGGRSA
ALGGVTTHIDFADMEATSLMKGLENRLEETRDSVIDFHFHIVINNNFNPLKQNHQLREIRDFGISSLKAFTTYKNIYMLS
SDKWEPLFKAAGDNDLIVAVHAEDNEIIEKNIVKFQKENKLDAQYHPDIRPSEAEQKAVKKICEIAHKTNASLYIVHLSS
EKGYQVVKEYKNLKNFKLYVETTPHYLLLTRELLKGPKASFYFMTPPLRESQDNEALWEGIQKGLIDVIATDHCAYNAEQ
KSMGKNSLDIFPGIPGVETLLALTYTYGVNKGLISINRLVELLSTNPAKIFKLYPQKGTIAIDSDADLVIFDPNLKEVLN
SSNTHSKAAYTPFEGFEVEGLPITTILRGKVIVKDRNFLGEKGFGRFIKAI

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=32.1739130434783, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4503375, Length=464, Percent_Identity=31.8965517241379, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4503051, Length=456, Percent_Identity=30.4824561403509, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI62422571, Length=456, Percent_Identity=30.4824561403509, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4503377, Length=460, Percent_Identity=30.6521739130435, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI19923821, Length=455, Percent_Identity=30.5494505494506, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI190194363, Length=460, Percent_Identity=27.6086956521739, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI18105007, Length=241, Percent_Identity=32.3651452282158, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=36.2255965292842, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=28.1531531531532, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=30.4347826086957, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71989490, Length=461, Percent_Identity=29.9349240780911, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI86575075, Length=440, Percent_Identity=25.6818181818182, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI193204318, Length=456, Percent_Identity=26.5350877192982, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322218, Length=448, Percent_Identity=26.7857142857143, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17137462, Length=454, Percent_Identity=31.9383259911894, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI221377917, Length=456, Percent_Identity=31.7982456140351, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24644287, Length=295, Percent_Identity=29.4915254237288, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642586, Length=409, Percent_Identity=26.6503667481663, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644289, Length=231, Percent_Identity=31.6017316017316, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859883, Length=286, Percent_Identity=26.9230769230769, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 50923; Mature: 50923

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKNGIVVTATKTEKKDIRILDEKIKQIESNLTPFMDEEVIDASGKYVFPGIIDSHTHF
CEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEECCEECCCCEE
SLHARGTTSIDDFYWGGRSAALGGVTTHIDFADMEATSLMKGLENRLEETRDSVIDFHFH
EEEECCCCCCHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
IVINNNFNPLKQNHQLREIRDFGISSLKAFTTYKNIYMLSSDKWEPLFKAAGDNDLIVAV
EEEECCCCCCHHCCHHHHHHHCCHHHHHHHEEEEEEEEEECCCCCHHHHCCCCCCEEEEE
HAEDNEIIEKNIVKFQKENKLDAQYHPDIRPSEAEQKAVKKICEIAHKTNASLYIVHLSS
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
EKGYQVVKEYKNLKNFKLYVETTPHYLLLTRELLKGPKASFYFMTPPLRESQDNEALWEG
CCCHHHHHHHCCCCCEEEEEECCCCCEEEEHHHHCCCCCEEEEECCCCCCCCCCHHHHHH
IQKGLIDVIATDHCAYNAEQKSMGKNSLDIFPGIPGVETLLALTYTYGVNKGLISINRLV
HHHHHHHHHCCCCCCCCCHHHHCCCCCCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ELLSTNPAKIFKLYPQKGTIAIDSDADLVIFDPNLKEVLNSSNTHSKAAYTPFEGFEVEG
HHHCCCCCCEEEEECCCCCEEECCCCCEEEECCCHHHHHCCCCCCCCEEECCCCCEEECC
LPITTILRGKVIVKDRNFLGEKGFGRFIKAI
CEEEEEEECEEEEECCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MLIKNGIVVTATKTEKKDIRILDEKIKQIESNLTPFMDEEVIDASGKYVFPGIIDSHTHF
CEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEECCEECCCCEE
SLHARGTTSIDDFYWGGRSAALGGVTTHIDFADMEATSLMKGLENRLEETRDSVIDFHFH
EEEECCCCCCHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
IVINNNFNPLKQNHQLREIRDFGISSLKAFTTYKNIYMLSSDKWEPLFKAAGDNDLIVAV
EEEECCCCCCHHCCHHHHHHHCCHHHHHHHEEEEEEEEEECCCCCHHHHCCCCCCEEEEE
HAEDNEIIEKNIVKFQKENKLDAQYHPDIRPSEAEQKAVKKICEIAHKTNASLYIVHLSS
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
EKGYQVVKEYKNLKNFKLYVETTPHYLLLTRELLKGPKASFYFMTPPLRESQDNEALWEG
CCCHHHHHHHCCCCCEEEEEECCCCCEEEEHHHHCCCCCEEEEECCCCCCCCCCHHHHHH
IQKGLIDVIATDHCAYNAEQKSMGKNSLDIFPGIPGVETLLALTYTYGVNKGLISINRLV
HHHHHHHHHCCCCCCCCCHHHHCCCCCCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ELLSTNPAKIFKLYPQKGTIAIDSDADLVIFDPNLKEVLNSSNTHSKAAYTPFEGFEVEG
HHHCCCCCCEEEEECCCCCEEECCCCCEEEECCCHHHHHCCCCCCCCEEECCCCCEEECC
LPITTILRGKVIVKDRNFLGEKGFGRFIKAI
CEEEEEEECEEEEECCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]