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The map label for this gene is kbl [C]

Identifier: 160902992

GI number: 160902992

Start: 1682405

End: 1683586

Strand: Direct

Name: kbl [C]

Synonym: Pmob_1549

Alternate gene names: 160902992

Gene position: 1682405-1683586 (Clockwise)

Preceding gene: 160902991

Following gene: 160902993

Centisome position: 77.55

GC content: 35.53

Gene sequence:

>1182_bases
ATGGATTTTTATGAACAATTGAGAGAAGAGTTGAAAAAGCTCGAAGACTCTGGTTTACTTATCACCATAAGAACACTTGA
AAGTGCACAAGGCGCTTGGATCAATATCAATGGTAAAAAGGTTTTAAATATGTGTTCTAACAATTATTTGGGTTTGGCAA
ACAACGAAAGGCTTAAAGAAGCTGCTATTAATGCGATTAAAAACTGGGGTGTAGGTCCAGGTGCAGTTAGAACAATAGCT
GGGACTATGAAGATTCACGAAGAATTAGAAAAAAAGCTAGCGGAATTTAAAAAAGTAGAGGCAACTCTCGTTGTTCAATC
TGGGTTCAACGCAAATCAAGCAGTTATTCCTACTATAACAAACGAAGAAGATGGCATTTTATCAGATGAACTTAACCACG
CTAGCATAATAGACGGTGTTAGATTATCAAAGGCAAAAAGATATATTTGGAAACATAAAGATTTAAACTCCTTGGAAGAG
CAACTGGTTAAGGCTCAAAGGGATAATTGTAGAAGAAAATTAATTATAACTGACGGTGTTTTTAGTATGGATGGAGATAT
TGCGCCTCTACCAGGAATTGTAGAATTAGCCAAAAAATATGATGCTTTAGTAATGGTGGATGATGCACATGGGGAAGGAG
TACTAGGAGAAAACGGTAGAGGAATAGCGGATCATTTCAATTTGACAGAGGAAGTGGATATAGAAATTGGAACTTTATCG
AAAGCTTTTGGAGTGGTAGGCGGATTTATAGCAGGTAAAAAAGTATTAATTGATTATTTGAAGCAACAAGCAAGGCCCTT
TCTATTCTCTAGTTCTTTATCTCCAGCAGAAACGGCTGCCGCTTTAGAAGCAACAAAAATACTTTATGAATCTGACGATT
TAGTGAAAAAGCTGTGGGATAATGCAAAATATTTTCAAAGTAAGATAAAAGAAATGGGCTATGATATCGGAGGCACTGAA
ACTCCTATAACCCCTGTGATGATATATGATGAAAAGAAAACAAAAGAATTTAGCTCAAAACTATATGAAGAAGGAATTTT
TGCGTCTAGTATAGTTTATCCCACCGTTCCAAAAGGTAAAGCCAGGATAAGGGTAATGATAAGCGCATTACACAGTAAAG
AAGACTTAGACTTTGCTTTAAGCAAATTTGAAAAAATAGGTAAAAGTCTTGGTACTCTATAA

Upstream 100 bases:

>100_bases
AATTTGACTTTGAAAATTTTGAAGAAGCTTTCGAATTGATGGCCAGTGGGAAAAGCGGTAAGATAGTTTTAAACGTTACA
AAAGAGGAGGAGGTTTGATT

Downstream 100 bases:

>100_bases
ATAAATTGTTGTGTAATTTTTAATTTTTATGATATAATAAATAAGAAAATGTTTTTTGTAATTTCAATAATTTTAAATTT
AGAAATTAGATTTAAAGTAA

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDFYEQLREELKKLEDSGLLITIRTLESAQGAWININGKKVLNMCSNNYLGLANNERLKEAAINAIKNWGVGPGAVRTIA
GTMKIHEELEKKLAEFKKVEATLVVQSGFNANQAVIPTITNEEDGILSDELNHASIIDGVRLSKAKRYIWKHKDLNSLEE
QLVKAQRDNCRRKLIITDGVFSMDGDIAPLPGIVELAKKYDALVMVDDAHGEGVLGENGRGIADHFNLTEEVDIEIGTLS
KAFGVVGGFIAGKKVLIDYLKQQARPFLFSSSLSPAETAAALEATKILYESDDLVKKLWDNAKYFQSKIKEMGYDIGGTE
TPITPVMIYDEKKTKEFSSKLYEEGIFASSIVYPTVPKGKARIRVMISALHSKEDLDFALSKFEKIGKSLGTL

Sequences:

>Translated_393_residues
MDFYEQLREELKKLEDSGLLITIRTLESAQGAWININGKKVLNMCSNNYLGLANNERLKEAAINAIKNWGVGPGAVRTIA
GTMKIHEELEKKLAEFKKVEATLVVQSGFNANQAVIPTITNEEDGILSDELNHASIIDGVRLSKAKRYIWKHKDLNSLEE
QLVKAQRDNCRRKLIITDGVFSMDGDIAPLPGIVELAKKYDALVMVDDAHGEGVLGENGRGIADHFNLTEEVDIEIGTLS
KAFGVVGGFIAGKKVLIDYLKQQARPFLFSSSLSPAETAAALEATKILYESDDLVKKLWDNAKYFQSKIKEMGYDIGGTE
TPITPVMIYDEKKTKEFSSKLYEEGIFASSIVYPTVPKGKARIRVMISALHSKEDLDFALSKFEKIGKSLGTL
>Mature_393_residues
MDFYEQLREELKKLEDSGLLITIRTLESAQGAWININGKKVLNMCSNNYLGLANNERLKEAAINAIKNWGVGPGAVRTIA
GTMKIHEELEKKLAEFKKVEATLVVQSGFNANQAVIPTITNEEDGILSDELNHASIIDGVRLSKAKRYIWKHKDLNSLEE
QLVKAQRDNCRRKLIITDGVFSMDGDIAPLPGIVELAKKYDALVMVDDAHGEGVLGENGRGIADHFNLTEEVDIEIGTLS
KAFGVVGGFIAGKKVLIDYLKQQARPFLFSSSLSPAETAAALEATKILYESDDLVKKLWDNAKYFQSKIKEMGYDIGGTE
TPITPVMIYDEKKTKEFSSKLYEEGIFASSIVYPTVPKGKARIRVMISALHSKEDLDFALSKFEKIGKSLGTL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=41.7948717948718, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=39.1826923076923, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=38.3152173913043, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI119220554, Length=371, Percent_Identity=36.6576819407008, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4502025, Length=361, Percent_Identity=34.3490304709141, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI40316939, Length=361, Percent_Identity=34.3490304709141, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=33.0459770114943, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=33.0459770114943, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=33.0459770114943, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI5454084, Length=379, Percent_Identity=27.1767810026385, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=44.9238578680203, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=34.0845070422535, Blast_Score=205, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=41.4572864321608, Blast_Score=317, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=32.1621621621622, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=32.1428571428571, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=31.9559228650138, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=31.7073170731707, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=31.7073170731707, Blast_Score=160, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=31.1475409836066, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6320438, Length=376, Percent_Identity=32.1808510638298, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=33.2089552238806, Blast_Score=159, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24662918, Length=392, Percent_Identity=44.8979591836735, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=35.4107648725212, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24653280, Length=397, Percent_Identity=26.448362720403, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24653276, Length=397, Percent_Identity=26.448362720403, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24653278, Length=397, Percent_Identity=26.448362720403, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_PETMO (A9BGL0)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568573.1
- ProteinModelPortal:   A9BGL0
- SMR:   A9BGL0
- GeneID:   5758146
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1549
- HOGENOM:   HBG649839
- OMA:   LSRAKII
- ProtClustDB:   CLSK976000
- BioCyc:   PMOB403833:PMOB_1549-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR13693:SF15
- TIGRFAMs:   TIGR00858
- TIGRFAMs:   TIGR01825

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 43506; Mature: 43506

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 133-133 BINDING 182-182 BINDING 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFYEQLREELKKLEDSGLLITIRTLESAQGAWININGKKVLNMCSNNYLGLANNERLKE
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECHHHHHHHHCCCCEECCCCHHHHH
AAINAIKNWGVGPGAVRTIAGTMKIHEELEKKLAEFKKVEATLVVQSGFNANQAVIPTIT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEC
NEEDGILSDELNHASIIDGVRLSKAKRYIWKHKDLNSLEEQLVKAQRDNCRRKLIITDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCE
FSMDGDIAPLPGIVELAKKYDALVMVDDAHGEGVLGENGRGIADHFNLTEEVDIEIGTLS
EECCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEEEHHH
KAFGVVGGFIAGKKVLIDYLKQQARPFLFSSSLSPAETAAALEATKILYESDDLVKKLWD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHC
NAKYFQSKIKEMGYDIGGTETPITPVMIYDEKKTKEFSSKLYEEGIFASSIVYPTVPKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEECCCCCCCC
ARIRVMISALHSKEDLDFALSKFEKIGKSLGTL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFYEQLREELKKLEDSGLLITIRTLESAQGAWININGKKVLNMCSNNYLGLANNERLKE
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEECHHHHHHHHCCCCEECCCCHHHHH
AAINAIKNWGVGPGAVRTIAGTMKIHEELEKKLAEFKKVEATLVVQSGFNANQAVIPTIT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEC
NEEDGILSDELNHASIIDGVRLSKAKRYIWKHKDLNSLEEQLVKAQRDNCRRKLIITDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCE
FSMDGDIAPLPGIVELAKKYDALVMVDDAHGEGVLGENGRGIADHFNLTEEVDIEIGTLS
EECCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEEEHHH
KAFGVVGGFIAGKKVLIDYLKQQARPFLFSSSLSPAETAAALEATKILYESDDLVKKLWD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHC
NAKYFQSKIKEMGYDIGGTETPITPVMIYDEKKTKEFSSKLYEEGIFASSIVYPTVPKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEECCCCCCCC
ARIRVMISALHSKEDLDFALSKFEKIGKSLGTL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA