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The map label for this gene is tdh [H]

Identifier: 160902991

GI number: 160902991

Start: 1681350

End: 1682402

Strand: Direct

Name: tdh [H]

Synonym: Pmob_1548

Alternate gene names: 160902991

Gene position: 1681350-1682402 (Clockwise)

Preceding gene: 160902990

Following gene: 160902992

Centisome position: 77.5

GC content: 36.18

Gene sequence:

>1053_bases
ATGAAGGCTATTGTAAAAGCCAAACCAGGAAAAGGGTTAACCCTAATGGAAGTAGAAGAACCAACTTTACAGTTTTCACA
CGATGTAAAGATTAAAATTTTAAAAGTATCGGTATGTGGGACTGATGTACATATTTACGAATGGAATGATTGGGCAAAAG
ACCGAATTAAGCAATTCCCACAAATCGATGGCCATGAATTTGTTGGAAGGGTAATCGAAGTTGGAAATGAAGTTAAAAGC
GTTAAACCTGGAGATTTAGTTGTTTCAGACAGTCATATACCTTGTGGTTATTGTCATCAGTGTAGAACAGGAAATATGCA
TGTATGCCAGAATTTAAAGATCTTAGGAGTAGATAGAGATGGCGTTTTTTCTGAATACGCCGTTCTACCAGATACAGTTT
TGATAAAAATCGACGAAAGTATACCTTTAAAATATGCATCTGTGATGGAACCTTTGGGAAATGCGATTTTTACAACAACT
GCAGCCGATCTTAGAGGTAAAGTAGTTTTAATTGCCGGAGCGGGACCTATTGGCGCTATGGCGATAGAAATTGCCAAATT
ATCCGGAGCAGCTTTCATTATAGTAAGTGAACCTTCTGATTACAGGATCAATATGGCAAAATCTTTAGGGGCTGATTTAG
TTATAAATCCGAAGGAGAAGTCTGTAGTTGAAGAAGTATTAAAAATAACCTCTGGATTGGGAGCAGATGTCTTTCTTGAA
ATGTCAGGAAATGAAAACGCTTTGAATGATGGTATAAAATCATTAAAAAGCACAGGAGTGGCATCTATCTTAGGGGTTTA
TCCTGAAAGCAAGATAAAGTTTGAAATGAATACCGCAGTTTTTAAAAATCTTACTATTCACACGATTACTGGAAGAAAGA
TGTTTGAAACGTGGTATATGGCTATAAACTGGCTGAAATATCATAAATTGGATTTAAGTAAAGTCGTTACGCATGAATTT
GACTTTGAAAATTTTGAAGAAGCTTTCGAATTGATGGCCAGTGGGAAAAGCGGTAAGATAGTTTTAAACGTTACAAAAGA
GGAGGAGGTTTGA

Upstream 100 bases:

>100_bases
GTCTATTTTTGCCTATAAACTACTCTCCTGAGGTTTGAAAAAAATTTCATAGTGAGTTACTATATATAATAGTAGTTATC
TTTTAAAGGAGAGTGAAAAA

Downstream 100 bases:

>100_bases
TTATGGATTTTTATGAACAATTGAGAGAAGAGTTGAAAAAGCTCGAAGACTCTGGTTTACTTATCACCATAAGAACACTT
GAAAGTGCACAAGGCGCTTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKAIVKAKPGKGLTLMEVEEPTLQFSHDVKIKILKVSVCGTDVHIYEWNDWAKDRIKQFPQIDGHEFVGRVIEVGNEVKS
VKPGDLVVSDSHIPCGYCHQCRTGNMHVCQNLKILGVDRDGVFSEYAVLPDTVLIKIDESIPLKYASVMEPLGNAIFTTT
AADLRGKVVLIAGAGPIGAMAIEIAKLSGAAFIIVSEPSDYRINMAKSLGADLVINPKEKSVVEEVLKITSGLGADVFLE
MSGNENALNDGIKSLKSTGVASILGVYPESKIKFEMNTAVFKNLTIHTITGRKMFETWYMAINWLKYHKLDLSKVVTHEF
DFENFEEAFELMASGKSGKIVLNVTKEEEV

Sequences:

>Translated_350_residues
MKAIVKAKPGKGLTLMEVEEPTLQFSHDVKIKILKVSVCGTDVHIYEWNDWAKDRIKQFPQIDGHEFVGRVIEVGNEVKS
VKPGDLVVSDSHIPCGYCHQCRTGNMHVCQNLKILGVDRDGVFSEYAVLPDTVLIKIDESIPLKYASVMEPLGNAIFTTT
AADLRGKVVLIAGAGPIGAMAIEIAKLSGAAFIIVSEPSDYRINMAKSLGADLVINPKEKSVVEEVLKITSGLGADVFLE
MSGNENALNDGIKSLKSTGVASILGVYPESKIKFEMNTAVFKNLTIHTITGRKMFETWYMAINWLKYHKLDLSKVVTHEF
DFENFEEAFELMASGKSGKIVLNVTKEEEV
>Mature_350_residues
MKAIVKAKPGKGLTLMEVEEPTLQFSHDVKIKILKVSVCGTDVHIYEWNDWAKDRIKQFPQIDGHEFVGRVIEVGNEVKS
VKPGDLVVSDSHIPCGYCHQCRTGNMHVCQNLKILGVDRDGVFSEYAVLPDTVLIKIDESIPLKYASVMEPLGNAIFTTT
AADLRGKVVLIAGAGPIGAMAIEIAKLSGAAFIIVSEPSDYRINMAKSLGADLVINPKEKSVVEEVLKITSGLGADVFLE
MSGNENALNDGIKSLKSTGVASILGVYPESKIKFEMNTAVFKNLTIHTITGRKMFETWYMAINWLKYHKLDLSKVVTHEF
DFENFEEAFELMASGKSGKIVLNVTKEEEV

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=28.7878787878788, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=29.3296089385475, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI156523966, Length=384, Percent_Identity=27.8645833333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501939, Length=378, Percent_Identity=28.042328042328, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=28.3018867924528, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=29.3650793650794, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=27.7628032345013, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI262073058, Length=358, Percent_Identity=27.0949720670391, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI71743840, Length=358, Percent_Identity=27.0949720670391, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=39.8255813953488, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=31.0850439882698, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=27.9279279279279, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=28.3783783783784, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790718, Length=328, Percent_Identity=26.5243902439024, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87082125, Length=366, Percent_Identity=30.327868852459, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI226510992, Length=302, Percent_Identity=26.158940397351, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=25.748502994012, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786825, Length=385, Percent_Identity=25.1948051948052, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=28.4574468085106, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081918, Length=245, Percent_Identity=28.9795918367347, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786518, Length=263, Percent_Identity=27.3764258555133, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787572, Length=202, Percent_Identity=27.7227722772277, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=309, Percent_Identity=29.7734627831715, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562878, Length=325, Percent_Identity=26.7692307692308, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=28.6111111111111, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=28.4530386740331, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=27.9883381924198, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=298, Percent_Identity=25.503355704698, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=246, Percent_Identity=29.6747967479675, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=273, Percent_Identity=24.1758241758242, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=27.217125382263, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=27.217125382263, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=29.1666666666667, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=29.6195652173913, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319257, Length=302, Percent_Identity=29.4701986754967, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=27.34375, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=266, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=265, Percent_Identity=27.1698113207547, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=291, Percent_Identity=26.1168384879725, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=276, Percent_Identity=25.7246376811594, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=227, Percent_Identity=28.1938325991189, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=26.7477203647416, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137530, Length=336, Percent_Identity=26.7857142857143, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=28.5318559556787, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550770, Length=333, Percent_Identity=23.4234234234234, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221457811, Length=333, Percent_Identity=23.4234234234234, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551930, Length=333, Percent_Identity=23.4234234234234, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38522; Mature: 38522

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVKAKPGKGLTLMEVEEPTLQFSHDVKIKILKVSVCGTDVHIYEWNDWAKDRIKQFP
CCCEEECCCCCCEEEEEECCCCEEECCCEEEEEEEEEEECCEEEEEECCCHHHHHHHHCC
QIDGHEFVGRVIEVGNEVKSVKPGDLVVSDSHIPCGYCHQCRTGNMHVCQNLKILGVDRD
CCCCHHHHHHHHHCCCHHCCCCCCCEEEECCCCCCCHHHCCCCCCEEEECCEEEEEECCC
GVFSEYAVLPDTVLIKIDESIPLKYASVMEPLGNAIFTTTAADLRGKVVLIAGAGPIGAM
CCCCCCEECCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEHHCCCCCEEEEECCCCCCCE
AIEIAKLSGAAFIIVSEPSDYRINMAKSLGADLVINPKEKSVVEEVLKITSGLGADVFLE
EEEEEEECCEEEEEEECCCCCEEEEHHHCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEE
MSGNENALNDGIKSLKSTGVASILGVYPESKIKFEMNTAVFKNLTIHTITGRKMFETWYM
ECCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECHHHHCCEEEEEECCCHHHHHHHH
AINWLKYHKLDLSKVVTHEFDFENFEEAFELMASGKSGKIVLNVTKEEEV
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKAIVKAKPGKGLTLMEVEEPTLQFSHDVKIKILKVSVCGTDVHIYEWNDWAKDRIKQFP
CCCEEECCCCCCEEEEEECCCCEEECCCEEEEEEEEEEECCEEEEEECCCHHHHHHHHCC
QIDGHEFVGRVIEVGNEVKSVKPGDLVVSDSHIPCGYCHQCRTGNMHVCQNLKILGVDRD
CCCCHHHHHHHHHCCCHHCCCCCCCEEEECCCCCCCHHHCCCCCCEEEECCEEEEEECCC
GVFSEYAVLPDTVLIKIDESIPLKYASVMEPLGNAIFTTTAADLRGKVVLIAGAGPIGAM
CCCCCCEECCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEHHCCCCCEEEEECCCCCCCE
AIEIAKLSGAAFIIVSEPSDYRINMAKSLGADLVINPKEKSVVEEVLKITSGLGADVFLE
EEEEEEECCEEEEEEECCCCCEEEEHHHCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEE
MSGNENALNDGIKSLKSTGVASILGVYPESKIKFEMNTAVFKNLTIHTITGRKMFETWYM
ECCCCCHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECHHHHCCEEEEEECCCHHHHHHHH
AINWLKYHKLDLSKVVTHEFDFENFEEAFELMASGKSGKIVLNVTKEEEV
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]