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The map label for this gene is dnaX [H]

Identifier: 160902859

GI number: 160902859

Start: 1519375

End: 1520778

Strand: Direct

Name: dnaX [H]

Synonym: Pmob_1414

Alternate gene names: 160902859

Gene position: 1519375-1520778 (Clockwise)

Preceding gene: 160902858

Following gene: 160902860

Centisome position: 70.03

GC content: 33.97

Gene sequence:

>1404_bases
GTGAACAATAATTTATATAGAAAATACAGACCAAAAGATTTTGATGAAATTTTAGGACAACCTCATGTAGTAAAATACTT
TAAAAACGCTTTGAACAAGCAAGAAGTTTCTCATGCTTATATTTTTTCGGGTCCGCGGGGCACCGGGAAAACCACTACCG
CCAGAATACTTGCCAAGGTATTAAATTGTAAGGATCCTCAAGGGTACAATCCTTGCAACAAATGCGAGAACTGTGTTTCT
ATAAACAATAACAGTTTTTTGGATGTAATTGAAATGGATGCGGCTTCGAATAGAGGAATAGACGAAATTAGAAACATCAG
GGACTCCTCCAATTACAGGCCAGTCTATGGGAAATACAAAGTATATATAATCGATGAATTTCATATGTTGACAAGAGAAG
CATTCAACGCGCTATTAAAAACGTTAGAAGAACCACCTTCACATGTTATTTTTATTTTAGCAACCACAAATTTGGAAAAA
GTCCCTGATACCATCATTTCTAGGGCTCAAATTATAAACTTCAAAAATTTAGGTCAGAATGAAATAGTAGAAGGATTGAA
AAATATAGCAAGCTCTGAAGGAATAGAATATGAGTTAGACGCCCTAGAAATCATTGCTAAAAGGGCAAAAGGTGGGATGA
GAGATGCCATATCGATGTTGGAACAAGTAGAAAAATTTGGAGAGAAGAAGATCACTCACCAAGACACCCTCGATATACTA
GGTTTGTTCGATGAAAATTTTATTGTTCAATTCATAGAAAATGTCTACAATTCAAAAATCGATGAATTTTTGGCGCAATC
TGAAGATCTTTTCAATTTAGGGAAAGATCCAGAAATTCTTTTGGAGCAATCCATAGAATATATTTTTGATTCACTAATTA
ACGAGAAAAGAAGTAACTTAATTCACTTAATGGGGACATTCAACGATATACTTAAAGATTTAAAATACAGTGAAAATAAA
AGGTTGATTTTCGATGTGGAGATCTTAGATTTCATGCATAAAAATTCAACTACGTCCTCAACTATATCTTATGATAAAGA
AACAACTCCAAAAAGAAAACAAGTAGCCACAGAATCCGTTCCCAAAGAAACTCAACACCCAATTATGAAGAAGATTCTTG
ATTACTTCAGCGATCCACACGAGAAGAAGTCCAACATGGCTATATACTTCGCTATGCTATTTTCGAATCCGGAAATTGAA
AACAATAAAATACATTTCAAATTCTCCTCAAACCAAAAGTTAGAATATGAAATCCTAAAAAAGTATGTAGATGAATTAAA
GGTGAATATATTTTTGCTGATCGATGGATCATACGAAATCACTTTTTCTCTCGAAGGTGGCGAGGTGGAAAGTCTGACCC
AACAAAAAGAAAAAGCCAATTTGAGAGAAAAGAAACTGTTCTGA

Upstream 100 bases:

>100_bases
TCATATTTGAGGTATTAGAGGATAACAAAGAAGATGTGTTATCACTAATAAAAAACAAGGTGTACAAATTAAATCTTGTC
GGCAATTCGGAGGGAACTTT

Downstream 100 bases:

>100_bases
GGGAATTACATGCTTAATATAATCTCTGCAATGGGTGTTGAAGCACGAGCGATAATAAAATATTTAAATTTAAAAAAAAC
AACAGATAGACCTTTTGAGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNNNLYRKYRPKDFDEILGQPHVVKYFKNALNKQEVSHAYIFSGPRGTGKTTTARILAKVLNCKDPQGYNPCNKCENCVS
INNNSFLDVIEMDAASNRGIDEIRNIRDSSNYRPVYGKYKVYIIDEFHMLTREAFNALLKTLEEPPSHVIFILATTNLEK
VPDTIISRAQIINFKNLGQNEIVEGLKNIASSEGIEYELDALEIIAKRAKGGMRDAISMLEQVEKFGEKKITHQDTLDIL
GLFDENFIVQFIENVYNSKIDEFLAQSEDLFNLGKDPEILLEQSIEYIFDSLINEKRSNLIHLMGTFNDILKDLKYSENK
RLIFDVEILDFMHKNSTTSSTISYDKETTPKRKQVATESVPKETQHPIMKKILDYFSDPHEKKSNMAIYFAMLFSNPEIE
NNKIHFKFSSNQKLEYEILKKYVDELKVNIFLLIDGSYEITFSLEGGEVESLTQQKEKANLREKKLF

Sequences:

>Translated_467_residues
MNNNLYRKYRPKDFDEILGQPHVVKYFKNALNKQEVSHAYIFSGPRGTGKTTTARILAKVLNCKDPQGYNPCNKCENCVS
INNNSFLDVIEMDAASNRGIDEIRNIRDSSNYRPVYGKYKVYIIDEFHMLTREAFNALLKTLEEPPSHVIFILATTNLEK
VPDTIISRAQIINFKNLGQNEIVEGLKNIASSEGIEYELDALEIIAKRAKGGMRDAISMLEQVEKFGEKKITHQDTLDIL
GLFDENFIVQFIENVYNSKIDEFLAQSEDLFNLGKDPEILLEQSIEYIFDSLINEKRSNLIHLMGTFNDILKDLKYSENK
RLIFDVEILDFMHKNSTTSSTISYDKETTPKRKQVATESVPKETQHPIMKKILDYFSDPHEKKSNMAIYFAMLFSNPEIE
NNKIHFKFSSNQKLEYEILKKYVDELKVNIFLLIDGSYEITFSLEGGEVESLTQQKEKANLREKKLF
>Mature_467_residues
MNNNLYRKYRPKDFDEILGQPHVVKYFKNALNKQEVSHAYIFSGPRGTGKTTTARILAKVLNCKDPQGYNPCNKCENCVS
INNNSFLDVIEMDAASNRGIDEIRNIRDSSNYRPVYGKYKVYIIDEFHMLTREAFNALLKTLEEPPSHVIFILATTNLEK
VPDTIISRAQIINFKNLGQNEIVEGLKNIASSEGIEYELDALEIIAKRAKGGMRDAISMLEQVEKFGEKKITHQDTLDIL
GLFDENFIVQFIENVYNSKIDEFLAQSEDLFNLGKDPEILLEQSIEYIFDSLINEKRSNLIHLMGTFNDILKDLKYSENK
RLIFDVEILDFMHKNSTTSSTISYDKETTPKRKQVATESVPKETQHPIMKKILDYFSDPHEKKSNMAIYFAMLFSNPEIE
NNKIHFKFSSNQKLEYEILKKYVDELKVNIFLLIDGSYEITFSLEGGEVESLTQQKEKANLREKKLF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=275, Percent_Identity=28.7272727272727, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4506491, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI31881687, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306571, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194306567, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI6677723, Length=237, Percent_Identity=26.1603375527426, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786676, Length=277, Percent_Identity=41.1552346570397, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1787341, Length=137, Percent_Identity=31.3868613138686, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=271, Percent_Identity=25.830258302583, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17541988, Length=217, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71986063, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324039, Length=219, Percent_Identity=28.310502283105, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324478, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647857, Length=275, Percent_Identity=28.3636363636364, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859927, Length=298, Percent_Identity=26.8456375838926, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19921076, Length=216, Percent_Identity=26.8518518518519, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 53966; Mature: 53966

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNLYRKYRPKDFDEILGQPHVVKYFKNALNKQEVSHAYIFSGPRGTGKTTTARILAKV
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCHHHCCEEEEEECCCCCCCHHHHHHHHHH
LNCKDPQGYNPCNKCENCVSINNNSFLDVIEMDAASNRGIDEIRNIRDSSNYRPVYGKYK
HCCCCCCCCCHHHHHHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEE
VYIIDEFHMLTREAFNALLKTLEEPPSHVIFILATTNLEKVPDTIISRAQIINFKNLGQN
EEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHCCCHH
EIVEGLKNIASSEGIEYELDALEIIAKRAKGGMRDAISMLEQVEKFGEKKITHQDTLDIL
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLFDENFIVQFIENVYNSKIDEFLAQSEDLFNLGKDPEILLEQSIEYIFDSLINEKRSNL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCE
IHLMGTFNDILKDLKYSENKRLIFDVEILDFMHKNSTTSSTISYDKETTPKRKQVATESV
EEHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCC
PKETQHPIMKKILDYFSDPHEKKSNMAIYFAMLFSNPEIENNKIHFKFSSNQKLEYEILK
CCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHH
KYVDELKVNIFLLIDGSYEITFSLEGGEVESLTQQKEKANLREKKLF
HHHHHHCEEEEEEEECCEEEEEEECCCCHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure
MNNNLYRKYRPKDFDEILGQPHVVKYFKNALNKQEVSHAYIFSGPRGTGKTTTARILAKV
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCHHHCCEEEEEECCCCCCCHHHHHHHHHH
LNCKDPQGYNPCNKCENCVSINNNSFLDVIEMDAASNRGIDEIRNIRDSSNYRPVYGKYK
HCCCCCCCCCHHHHHHHHEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEE
VYIIDEFHMLTREAFNALLKTLEEPPSHVIFILATTNLEKVPDTIISRAQIINFKNLGQN
EEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHCCCHH
EIVEGLKNIASSEGIEYELDALEIIAKRAKGGMRDAISMLEQVEKFGEKKITHQDTLDIL
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLFDENFIVQFIENVYNSKIDEFLAQSEDLFNLGKDPEILLEQSIEYIFDSLINEKRSNL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCE
IHLMGTFNDILKDLKYSENKRLIFDVEILDFMHKNSTTSSTISYDKETTPKRKQVATESV
EEHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCC
PKETQHPIMKKILDYFSDPHEKKSNMAIYFAMLFSNPEIENNKIHFKFSSNQKLEYEILK
CCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHH
KYVDELKVNIFLLIDGSYEITFSLEGGEVESLTQQKEKANLREKKLF
HHHHHHCEEEEEEEECCEEEEEEECCCCHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]