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The map label for this gene is murA [H]

Identifier: 160901546

GI number: 160901546

Start: 49297

End: 50589

Strand: Direct

Name: murA [H]

Synonym: Pmob_0055

Alternate gene names: 160901546

Gene position: 49297-50589 (Clockwise)

Preceding gene: 160901545

Following gene: 160901551

Centisome position: 2.27

GC content: 37.05

Gene sequence:

>1293_bases
TTGAAAAGCATTGGTTTAGATACATCTGGAAAAATGATCGTAAAAGGACCTCAAAAGGCAAAAGGCACTTTAACCGTTTC
TGGAGCAAAAAACGCCGTGCTACCAATTATGGGAGCATCTTTACTCACTGATGATGATATTGATTTAAGGAATGTCCCAG
ATCTAGCAGACGTGAGAACCATGATTGAAATACTAGAAAGTGCAGGAAAAGTAATAGAACGTTTCGATGATCAATTGATA
ATTAAGAGTTCAGGTAATATCAATTCTGAGATTCCATATGAACCCGTAAGGAAAATGAGGGCTTCTTTCAACGTTTATGG
TCCATTAACCCTCAGGAATGGTTATGCGAAAGTTGCACTTCCAGGTGGATGTTCTATCGGTGCAAGACCTGTGGATTTTC
ATTTAGAGGGTTTAAAAAAGTTGGGAATAGAAAGTACGATTGAACACGGTTTCGTAACCAGTAAATTGAACAATCCTAAC
AGTTTTATAAATATATCCTTACCTTTTCCAAGTGTTGGAGCCACAGAGCATGTCTTGACCACCGCTTGCTTACTAGAAGG
CGTAAAAACGACTATCACCAATTGCGCTATAGAGCCAGAAGTAACTGATTTAGTAAACTTTCTAAATAAAATGGGAGCTA
AAATTACAGGTGGTGGAACCTCAATATTGAAAATTGAAGGCGTAAAAAAATTATCGGGGGTAAAATACACCATAATTCCT
GACAGAATTGAAGCTGGTACATACATCATACTAGGTAAACTCGTGGGCGAAAAACTAACCATAAAAAATGTATCTGCTGA
ACATCTAAATAGTTTATTCTCAGTATTTGATAATATTGGAAGCCCAGTAGATTACGACGAGAAAAAAAGAGAAGTAAAAG
TATCAGAAACTCTTCTCAATCCATTAAATAGTATCAGCATGGAGACAGCTCCTTTCCCGGGATTTCCAACAGATTTGCAA
CCTCAGATCACAACATTTTTATCTTTGGTCCCAGGCAGATCTACAATAACAGAAACTGTGTTTAAAAGTAGATTTTACCA
TATTGACGAATTGAACAGAATGGGAGCTAAGATTAGGGTAGAAGACAACACGGCAATTATAGAAGGAGTAAACAAACTAT
CGGGAGCGCCTGTAGAAGCTACAGATCTTAGAGCCGCAGCAGCTTTACTTATAGCTGGACTCGTTGCAGAAGGAGAAACA
ATTATTTCGAATGTGGATCATATCTTTAGAGGATATGAAAACATACACGAAAAATTGGAACAAGTGGGTATAGAATTAAT
TTATGAAAAATAA

Upstream 100 bases:

>100_bases
AGTTGAAGAAAGTGCAAGGAAGGTTTTTTCTGGTGAATTACTACCTACCGGAAATAAAAATTGGTAAAAGTTCTTTCATT
ATTTCTTAGGGGGGCTAAAA

Downstream 100 bases:

>100_bases
TGTTTTTTAGTTTTTAAAAAAGCTGGCTTCTTATAGCCAGCTTTTTGTTTTATCAATCATCTCAGAATTTAAATTCAGCT
TTGAGATATAGATACCAATG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKSIGLDTSGKMIVKGPQKAKGTLTVSGAKNAVLPIMGASLLTDDDIDLRNVPDLADVRTMIEILESAGKVIERFDDQLI
IKSSGNINSEIPYEPVRKMRASFNVYGPLTLRNGYAKVALPGGCSIGARPVDFHLEGLKKLGIESTIEHGFVTSKLNNPN
SFINISLPFPSVGATEHVLTTACLLEGVKTTITNCAIEPEVTDLVNFLNKMGAKITGGGTSILKIEGVKKLSGVKYTIIP
DRIEAGTYIILGKLVGEKLTIKNVSAEHLNSLFSVFDNIGSPVDYDEKKREVKVSETLLNPLNSISMETAPFPGFPTDLQ
PQITTFLSLVPGRSTITETVFKSRFYHIDELNRMGAKIRVEDNTAIIEGVNKLSGAPVEATDLRAAAALLIAGLVAEGET
IISNVDHIFRGYENIHEKLEQVGIELIYEK

Sequences:

>Translated_430_residues
MKSIGLDTSGKMIVKGPQKAKGTLTVSGAKNAVLPIMGASLLTDDDIDLRNVPDLADVRTMIEILESAGKVIERFDDQLI
IKSSGNINSEIPYEPVRKMRASFNVYGPLTLRNGYAKVALPGGCSIGARPVDFHLEGLKKLGIESTIEHGFVTSKLNNPN
SFINISLPFPSVGATEHVLTTACLLEGVKTTITNCAIEPEVTDLVNFLNKMGAKITGGGTSILKIEGVKKLSGVKYTIIP
DRIEAGTYIILGKLVGEKLTIKNVSAEHLNSLFSVFDNIGSPVDYDEKKREVKVSETLLNPLNSISMETAPFPGFPTDLQ
PQITTFLSLVPGRSTITETVFKSRFYHIDELNRMGAKIRVEDNTAIIEGVNKLSGAPVEATDLRAAAALLIAGLVAEGET
IISNVDHIFRGYENIHEKLEQVGIELIYEK
>Mature_430_residues
MKSIGLDTSGKMIVKGPQKAKGTLTVSGAKNAVLPIMGASLLTDDDIDLRNVPDLADVRTMIEILESAGKVIERFDDQLI
IKSSGNINSEIPYEPVRKMRASFNVYGPLTLRNGYAKVALPGGCSIGARPVDFHLEGLKKLGIESTIEHGFVTSKLNNPN
SFINISLPFPSVGATEHVLTTACLLEGVKTTITNCAIEPEVTDLVNFLNKMGAKITGGGTSILKIEGVKKLSGVKYTIIP
DRIEAGTYIILGKLVGEKLTIKNVSAEHLNSLFSVFDNIGSPVDYDEKKREVKVSETLLNPLNSISMETAPFPGFPTDLQ
PQITTFLSLVPGRSTITETVFKSRFYHIDELNRMGAKIRVEDNTAIIEGVNKLSGAPVEATDLRAAAALLIAGLVAEGET
IISNVDHIFRGYENIHEKLEQVGIELIYEK

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin [H]

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789580, Length=413, Percent_Identity=42.6150121065375, Blast_Score=328, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.7 [H]

Molecular weight: Translated: 46548; Mature: 46548

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIGLDTSGKMIVKGPQKAKGTLTVSGAKNAVLPIMGASLLTDDDIDLRNVPDLADVRT
CCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCHHHHCCHHCCCCCCCCCCCCCHHHHHH
MIEILESAGKVIERFDDQLIIKSSGNINSEIPYEPVRKMRASFNVYGPLTLRNGYAKVAL
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEECCEEEECCEEEEEE
PGGCSIGARPVDFHLEGLKKLGIESTIEHGFVTSKLNNPNSFINISLPFPSVGATEHVLT
CCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEECCCCCCEEEEECCCCCCCCHHHHHH
TACLLEGVKTTITNCAIEPEVTDLVNFLNKMGAKITGGGTSILKIEGVKKLSGVKYTIIP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCEEEEECCCHHHCCCEEEEEC
DRIEAGTYIILGKLVGEKLTIKNVSAEHLNSLFSVFDNIGSPVDYDEKKREVKVSETLLN
CCCCCCCEEEEEEHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
PLNSISMETAPFPGFPTDLQPQITTFLSLVPGRSTITETVFKSRFYHIDELNRMGAKIRV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
EDNTAIIEGVNKLSGAPVEATDLRAAAALLIAGLVAEGETIISNVDHIFRGYENIHEKLE
CCCHHEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QVGIELIYEK
HCCCEEEECC
>Mature Secondary Structure
MKSIGLDTSGKMIVKGPQKAKGTLTVSGAKNAVLPIMGASLLTDDDIDLRNVPDLADVRT
CCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCHHHHCCHHCCCCCCCCCCCCCHHHHHH
MIEILESAGKVIERFDDQLIIKSSGNINSEIPYEPVRKMRASFNVYGPLTLRNGYAKVAL
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEECCEEEECCEEEEEE
PGGCSIGARPVDFHLEGLKKLGIESTIEHGFVTSKLNNPNSFINISLPFPSVGATEHVLT
CCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEECCCCCCEEEEECCCCCCCCHHHHHH
TACLLEGVKTTITNCAIEPEVTDLVNFLNKMGAKITGGGTSILKIEGVKKLSGVKYTIIP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCEEEEECCCHHHCCCEEEEEC
DRIEAGTYIILGKLVGEKLTIKNVSAEHLNSLFSVFDNIGSPVDYDEKKREVKVSETLLN
CCCCCCCEEEEEEHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
PLNSISMETAPFPGFPTDLQPQITTFLSLVPGRSTITETVFKSRFYHIDELNRMGAKIRV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
EDNTAIIEGVNKLSGAPVEATDLRAAAALLIAGLVAEGETIISNVDHIFRGYENIHEKLE
CCCHHEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QVGIELIYEK
HCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]