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The map label for this gene is moeA [H]

Identifier: 160877562

GI number: 160877562

Start: 5270735

End: 5272546

Strand: Direct

Name: moeA [H]

Synonym: Sbal195_4461

Alternate gene names: 160877562

Gene position: 5270735-5272546 (Clockwise)

Preceding gene: 160877561

Following gene: 160877563

Centisome position: 98.57

GC content: 52.37

Gene sequence:

>1812_bases
ATGAGTAACCCCTTCGTCAATCCGCTCGCTATTCCCGTTCTCGGATTTTGTGCCTACAGTGGCACGGGGAAAACCACCTT
ACTCAAGCAATTGATCCCCGAACTAAATCAACGTGGTCTTCGCTTAGCCGTGATCAAACATGCGCACCATAATTTCGACG
TGGATATTCCCGGCAAAGACAGTTACGAAATGCGTAAAGCGGGTGCGCGGCAAATGCTGGTCGCTTCCCATGTGCGCTGG
GCGCTAATGACAGAAGATGCGCGCGATGGCGATCCTGAGTTAGTCCATTTGCTCAAGCAAATCGAAGCCGACAAAGTCGA
TATCGTCCTCGTCGAAGGCTTTAAAAAACTCGCTTTACCTAAAATTGAATTGCACCGCGCCGCCCACGGCAAACCTTTTA
TCTACACCCAAGATGAAAATATCCTCGCCATCGCCTGTTGCGATGATACTCAGTTGCCAAGCGACGCACTTCCAAATGAG
CTGCGCCGACTCGATCTCAACAATGTCAGCCAAATTGCCGACTTTGTCATTGAGTATGCCCAAAACTGGGAAGCGCCACT
CCAATACCCGATTTCAGCCGTGGATGCCTGCACCATAGGCGACAACAAAAACCTCAGCGTCAGCCAAGGTTTAGCGCAAA
TTTTATCCCATGTTTCACCCGTTGCAGAAGTCGAAGAGATTGACTTAGACGCCTTAGATAACCGCGTACTGGCCAGCGAC
AGTATTTCTCCCGTCGACGTGCCGCAACAAACTAATTCGGCGATGGATGGCTACGCCTTTGTCTATCAAGACCCCATGCC
TGCCACCTTAAAACGGGTGGGTGAGGTCCTTGCCGGTCATCAATATTCGGGCACGCTTAGCGTCGGCGAAACCGTGCGAA
TCATGACGGGCGCGACTGTGCCCGTGGGTGCCGATACTGTGCAGCCCCGTGAACTAGCGAAAGAAGTCGACGGCAATGTT
AACTTCGACGGCCGTATTCTGGCGGGTCAACACGTTCGCCTCGCGGGGGAAGATATCGCCCAAGGCCAAGTCGCCCTCGC
CAAAGCCACTCGCCTAAGCGCCGCCGAACAAGGTTTACTGGCTTCACTCGGGCTCAATCGCCTGAGTGTCTATCGCCGCC
CAACCGTTGCCGTGTTCTCCACCGGCGATGAAGTGAGCCAACCTGGCGAAGCACTCAAAGCCAACTGCATCTATGACTCA
AACCGCTTTACCATCAAAGCGATGGCGAAACGTCTTGGTTGTGATGTTATCGATTTAGGCATTATCGAAGATTCTGAAAC
CGCGCTCGAAGCGACGCTGGCTAAAGCCGCCACCCTTGCCGATGTTGTCCTTAGCTCTGGCGGCGTGTCAGTCGGTGATG
CGGATTACATTAAAACCGTACTTGCCCGCTTAGGCAAAATCGATTTTTGGCGGATTAGCATGCGTCCGGGTCGGCCACTC
GCCTTTGGTAAAATCGGTGATAGCTTATTCTTCGGACTGCCGGGCAACCCAGTGGCGGTAATGGTTACTTTCCTGCAATT
TGTGCAGCCCGCTTTGCGAAAATTGGCAGGTGAAGTGAACTGGCAAGCGCAGCTATTCCCCGCAATAAGTGATGAAACAC
TGCGAAGCCGCCAAGGCCGCACCGAATTTATTCGCGGGATTTATCAACTTGGCAAAGATGGACGCCTGCACGTAAGTAGC
ACGGGCAACCAAGGTTCCGGAATGTTAAGTTCAATGGTCAAAGGGAATTGTCTCATCATCATAGGCGATGATGCAGAAGC
CGTGAATGCAGGTGAAACTGTGTTTATTCAACCCTTTGCGGATCTGCTTTAA

Upstream 100 bases:

>100_bases
CAATGCCTTTGTAAATGTGAATACGCCAGAACAAAAACAACGACTGGCCATGGAAATTACCAAATAGCTAAGGCTCCAAT
AACCCAAATTAGAGGTGCAA

Downstream 100 bases:

>100_bases
GATCCAGTGAGTTTTTATGAGTCTAATGGTGGATTCCTTTGGCCGTAAGGTCGAATATTTACGGCTCTCAGTCACCGACC
GCTGCGACTTTCGCTGTGTC

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSNPFVNPLAIPVLGFCAYSGTGKTTLLKQLIPELNQRGLRLAVIKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRW
ALMTEDARDGDPELVHLLKQIEADKVDIVLVEGFKKLALPKIELHRAAHGKPFIYTQDENILAIACCDDTQLPSDALPNE
LRRLDLNNVSQIADFVIEYAQNWEAPLQYPISAVDACTIGDNKNLSVSQGLAQILSHVSPVAEVEEIDLDALDNRVLASD
SISPVDVPQQTNSAMDGYAFVYQDPMPATLKRVGEVLAGHQYSGTLSVGETVRIMTGATVPVGADTVQPRELAKEVDGNV
NFDGRILAGQHVRLAGEDIAQGQVALAKATRLSAAEQGLLASLGLNRLSVYRRPTVAVFSTGDEVSQPGEALKANCIYDS
NRFTIKAMAKRLGCDVIDLGIIEDSETALEATLAKAATLADVVLSSGGVSVGDADYIKTVLARLGKIDFWRISMRPGRPL
AFGKIGDSLFFGLPGNPVAVMVTFLQFVQPALRKLAGEVNWQAQLFPAISDETLRSRQGRTEFIRGIYQLGKDGRLHVSS
TGNQGSGMLSSMVKGNCLIIIGDDAEAVNAGETVFIQPFADLL

Sequences:

>Translated_603_residues
MSNPFVNPLAIPVLGFCAYSGTGKTTLLKQLIPELNQRGLRLAVIKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRW
ALMTEDARDGDPELVHLLKQIEADKVDIVLVEGFKKLALPKIELHRAAHGKPFIYTQDENILAIACCDDTQLPSDALPNE
LRRLDLNNVSQIADFVIEYAQNWEAPLQYPISAVDACTIGDNKNLSVSQGLAQILSHVSPVAEVEEIDLDALDNRVLASD
SISPVDVPQQTNSAMDGYAFVYQDPMPATLKRVGEVLAGHQYSGTLSVGETVRIMTGATVPVGADTVQPRELAKEVDGNV
NFDGRILAGQHVRLAGEDIAQGQVALAKATRLSAAEQGLLASLGLNRLSVYRRPTVAVFSTGDEVSQPGEALKANCIYDS
NRFTIKAMAKRLGCDVIDLGIIEDSETALEATLAKAATLADVVLSSGGVSVGDADYIKTVLARLGKIDFWRISMRPGRPL
AFGKIGDSLFFGLPGNPVAVMVTFLQFVQPALRKLAGEVNWQAQLFPAISDETLRSRQGRTEFIRGIYQLGKDGRLHVSS
TGNQGSGMLSSMVKGNCLIIIGDDAEAVNAGETVFIQPFADLL
>Mature_602_residues
SNPFVNPLAIPVLGFCAYSGTGKTTLLKQLIPELNQRGLRLAVIKHAHHNFDVDIPGKDSYEMRKAGARQMLVASHVRWA
LMTEDARDGDPELVHLLKQIEADKVDIVLVEGFKKLALPKIELHRAAHGKPFIYTQDENILAIACCDDTQLPSDALPNEL
RRLDLNNVSQIADFVIEYAQNWEAPLQYPISAVDACTIGDNKNLSVSQGLAQILSHVSPVAEVEEIDLDALDNRVLASDS
ISPVDVPQQTNSAMDGYAFVYQDPMPATLKRVGEVLAGHQYSGTLSVGETVRIMTGATVPVGADTVQPRELAKEVDGNVN
FDGRILAGQHVRLAGEDIAQGQVALAKATRLSAAEQGLLASLGLNRLSVYRRPTVAVFSTGDEVSQPGEALKANCIYDSN
RFTIKAMAKRLGCDVIDLGIIEDSETALEATLAKAATLADVVLSSGGVSVGDADYIKTVLARLGKIDFWRISMRPGRPLA
FGKIGDSLFFGLPGNPVAVMVTFLQFVQPALRKLAGEVNWQAQLFPAISDETLRSRQGRTEFIRGIYQLGKDGRLHVSST
GNQGSGMLSSMVKGNCLIIIGDDAEAVNAGETVFIQPFADLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=36.4556962025316, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI66932975, Length=396, Percent_Identity=36.3636363636364, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=44.987146529563, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI145693204, Length=173, Percent_Identity=48.5549132947977, Blast_Score=155, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=389, Percent_Identity=32.133676092545, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17562606, Length=326, Percent_Identity=28.8343558282209, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17136978, Length=378, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24638841, Length=378, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 65090; Mature: 64959

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPFVNPLAIPVLGFCAYSGTGKTTLLKQLIPELNQRGLRLAVIKHAHHNFDVDIPGKD
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCC
SYEMRKAGARQMLVASHVRWALMTEDARDGDPELVHLLKQIEADKVDIVLVEGFKKLALP
CHHHHHHCHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHCCC
KIELHRAAHGKPFIYTQDENILAIACCDDTQLPSDALPNELRRLDLNNVSQIADFVIEYA
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
QNWEAPLQYPISAVDACTIGDNKNLSVSQGLAQILSHVSPVAEVEEIDLDALDNRVLASD
HCCCCCCCCCCHHHCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHCCEEEECC
SISPVDVPQQTNSAMDGYAFVYQDPMPATLKRVGEVLAGHQYSGTLSVGETVRIMTGATV
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEECCCEEEEEECCCC
PVGADTVQPRELAKEVDGNVNFDGRILAGQHVRLAGEDIAQGQVALAKATRLSAAEQGLL
CCCCCCCCHHHHHHHHCCCCCCCCEEECCCEEEECCCHHCCCHHHHHHHHHHHHHHHHHH
ASLGLNRLSVYRRPTVAVFSTGDEVSQPGEALKANCIYDSNRFTIKAMAKRLGCDVIDLG
HHHCCHHHHHCCCCEEEEEECCCCCCCCCHHHEEEEEECCCCEEHHHHHHHHCCCEEEEE
IIEDSETALEATLAKAATLADVVLSSGGVSVGDADYIKTVLARLGKIDFWRISMRPGRPL
EECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCE
AFGKIGDSLFFGLPGNPVAVMVTFLQFVQPALRKLAGEVNWQAQLFPAISDETLRSRQGR
EEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCH
TEFIRGIYQLGKDGRLHVSSTGNQGSGMLSSMVKGNCLIIIGDDAEAVNAGETVFIQPFA
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHH
DLL
HCC
>Mature Secondary Structure 
SNPFVNPLAIPVLGFCAYSGTGKTTLLKQLIPELNQRGLRLAVIKHAHHNFDVDIPGKD
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCC
SYEMRKAGARQMLVASHVRWALMTEDARDGDPELVHLLKQIEADKVDIVLVEGFKKLALP
CHHHHHHCHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHCCC
KIELHRAAHGKPFIYTQDENILAIACCDDTQLPSDALPNELRRLDLNNVSQIADFVIEYA
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
QNWEAPLQYPISAVDACTIGDNKNLSVSQGLAQILSHVSPVAEVEEIDLDALDNRVLASD
HCCCCCCCCCCHHHCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHCCEEEECC
SISPVDVPQQTNSAMDGYAFVYQDPMPATLKRVGEVLAGHQYSGTLSVGETVRIMTGATV
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEECCCEEEEEECCCC
PVGADTVQPRELAKEVDGNVNFDGRILAGQHVRLAGEDIAQGQVALAKATRLSAAEQGLL
CCCCCCCCHHHHHHHHCCCCCCCCEEECCCEEEECCCHHCCCHHHHHHHHHHHHHHHHHH
ASLGLNRLSVYRRPTVAVFSTGDEVSQPGEALKANCIYDSNRFTIKAMAKRLGCDVIDLG
HHHCCHHHHHCCCCEEEEEECCCCCCCCCHHHEEEEEECCCCEEHHHHHHHHCCCEEEEE
IIEDSETALEATLAKAATLADVVLSSGGVSVGDADYIKTVLARLGKIDFWRISMRPGRPL
EECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCE
AFGKIGDSLFFGLPGNPVAVMVTFLQFVQPALRKLAGEVNWQAQLFPAISDETLRSRQGR
EEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCH
TEFIRGIYQLGKDGRLHVSSTGNQGSGMLSSMVKGNCLIIIGDDAEAVNAGETVFIQPFA
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCHH
DLL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]