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The map label for this gene is moaA2 [H]

Identifier: 160877563

GI number: 160877563

Start: 5272563

End: 5273546

Strand: Direct

Name: moaA2 [H]

Synonym: Sbal195_4462

Alternate gene names: 160877563

Gene position: 5272563-5273546 (Clockwise)

Preceding gene: 160877562

Following gene: 160877564

Centisome position: 98.6

GC content: 48.07

Gene sequence:

>984_bases
ATGAGTCTAATGGTGGATTCCTTTGGCCGTAAGGTCGAATATTTACGGCTCTCAGTCACCGACCGCTGCGACTTTCGCTG
TGTCTATTGCATGACGGAAGATCCCTGTTTTCTGCCAAAGGACCACGTACTCCACCTCGAAGAATTAGCTTGGATTGCCC
AAGCCTTTACCGAGCTTGGTGTGACTAAAATTCGCCTGACTGGCGGCGAGCCCTTAGTTCGCACCGATTGCGATCAGCTA
GTGAGTCTGCTTGGCAAACTGCCTGGGCTGACAGATTTGTCCATGACCACCAATGGTTCAAGGCTGACAAAATTCGCTAA
GCCCATGTTTGCTGCAGGATTAAAGCGCCTCAATATCAGCCTAGATACCTTAAACCCCACATTGTTTACCCAGTTAACAC
GTAACGGTAAGTTAGACAGAGTCATCGACGGTATCGATGCCGCCATTGCGGCGGGCTTTGAACGTATCAAGATTAATGCA
GTGATTTTAAAACAACAGAACGATAATGAAGTCATTGATTTAGTTGATTTCTGCCGTGGTCGCCGTTTAGATATCGCCTT
TATCGAAGAAATGCCACTTGGCGAAATAGATGAGCGTAAACGCGCCCGTCATTGCAGCAGTGATGAAGTCAAAGCCATCA
TAGAAAGCCGCTATCCGCTGCAGCTATCGAGCAAACGCACTGGCGGCCCAGCGCGGTATTACACTATGGCCGACAGCCCA
ATCCATATCGGTTTTATCTCACCCCACAGCCACAACTTCTGCCACGAATGCAATCGAGTACGCGTCACAGTCGAAGGCCA
ATTATTGCTGTGTTTGGGCAATGAGCATGCTGTTGATCTCAAAAGCATAGTCAGGGAATTTCCAGCAGATATTGAGAGAC
TTAAAGCCGCTATTCTCGCGGGCATTAACCTCAAGCCTAAGCAACACGACTTTGGCAATAATCAGGTACAAATTCTACGT
TTTATGAACGCCACTGGCGGTTAA

Upstream 100 bases:

>100_bases
TGTCTCATCATCATAGGCGATGATGCAGAAGCCGTGAATGCAGGTGAAACTGTGTTTATTCAACCCTTTGCGGATCTGCT
TTAAGATCCAGTGAGTTTTT

Downstream 100 bases:

>100_bases
GCATCCCCCCTCAATCGCTTAAGGGCTAGCATCTCAATTTTGCCGTGATAAACTCGAAGCATCACCCCATACTTAGCGTC
ACACATTTCTATGGCCTTAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSLMVDSFGRKVEYLRLSVTDRCDFRCVYCMTEDPCFLPKDHVLHLEELAWIAQAFTELGVTKIRLTGGEPLVRTDCDQL
VSLLGKLPGLTDLSMTTNGSRLTKFAKPMFAAGLKRLNISLDTLNPTLFTQLTRNGKLDRVIDGIDAAIAAGFERIKINA
VILKQQNDNEVIDLVDFCRGRRLDIAFIEEMPLGEIDERKRARHCSSDEVKAIIESRYPLQLSSKRTGGPARYYTMADSP
IHIGFISPHSHNFCHECNRVRVTVEGQLLLCLGNEHAVDLKSIVREFPADIERLKAAILAGINLKPKQHDFGNNQVQILR
FMNATGG

Sequences:

>Translated_327_residues
MSLMVDSFGRKVEYLRLSVTDRCDFRCVYCMTEDPCFLPKDHVLHLEELAWIAQAFTELGVTKIRLTGGEPLVRTDCDQL
VSLLGKLPGLTDLSMTTNGSRLTKFAKPMFAAGLKRLNISLDTLNPTLFTQLTRNGKLDRVIDGIDAAIAAGFERIKINA
VILKQQNDNEVIDLVDFCRGRRLDIAFIEEMPLGEIDERKRARHCSSDEVKAIIESRYPLQLSSKRTGGPARYYTMADSP
IHIGFISPHSHNFCHECNRVRVTVEGQLLLCLGNEHAVDLKSIVREFPADIERLKAAILAGINLKPKQHDFGNNQVQILR
FMNATGG
>Mature_326_residues
SLMVDSFGRKVEYLRLSVTDRCDFRCVYCMTEDPCFLPKDHVLHLEELAWIAQAFTELGVTKIRLTGGEPLVRTDCDQLV
SLLGKLPGLTDLSMTTNGSRLTKFAKPMFAAGLKRLNISLDTLNPTLFTQLTRNGKLDRVIDGIDAAIAAGFERIKINAV
ILKQQNDNEVIDLVDFCRGRRLDIAFIEEMPLGEIDERKRARHCSSDEVKAIIESRYPLQLSSKRTGGPARYYTMADSPI
HIGFISPHSHNFCHECNRVRVTVEGQLLLCLGNEHAVDLKSIVREFPADIERLKAAILAGINLKPKQHDFGNNQVQILRF
MNATGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=310, Percent_Identity=35.8064516129032, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI116734668, Length=310, Percent_Identity=35.8064516129032, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=34.1463414634146, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17561210, Length=308, Percent_Identity=37.012987012987, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=36.3636363636364, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32566329, Length=308, Percent_Identity=36.3636363636364, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI28574488, Length=310, Percent_Identity=39.0322580645161, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI28574490, Length=310, Percent_Identity=39.0322580645161, Blast_Score=204, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36685; Mature: 36554

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS01305 MOAA_NIFB_PQQE ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMVDSFGRKVEYLRLSVTDRCDFRCVYCMTEDPCFLPKDHVLHLEELAWIAQAFTELG
CCCCHHHHCCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
VTKIRLTGGEPLVRTDCDQLVSLLGKLPGLTDLSMTTNGSRLTKFAKPMFAAGLKRLNIS
CEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCHHHEEEE
LDTLNPTLFTQLTRNGKLDRVIDGIDAAIAAGFERIKINAVILKQQNDNEVIDLVDFCRG
EECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHCC
RRLDIAFIEEMPLGEIDERKRARHCSSDEVKAIIESRYPLQLSSKRTGGPARYYTMADSP
CCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCC
IHIGFISPHSHNFCHECNRVRVTVEGQLLLCLGNEHAVDLKSIVREFPADIERLKAAILA
EEEEEECCCCCCHHHCCCEEEEEECCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
GINLKPKQHDFGNNQVQILRFMNATGG
CCCCCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
SLMVDSFGRKVEYLRLSVTDRCDFRCVYCMTEDPCFLPKDHVLHLEELAWIAQAFTELG
CCCHHHHCCEEEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
VTKIRLTGGEPLVRTDCDQLVSLLGKLPGLTDLSMTTNGSRLTKFAKPMFAAGLKRLNIS
CEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCHHHEEEE
LDTLNPTLFTQLTRNGKLDRVIDGIDAAIAAGFERIKINAVILKQQNDNEVIDLVDFCRG
EECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHCC
RRLDIAFIEEMPLGEIDERKRARHCSSDEVKAIIESRYPLQLSSKRTGGPARYYTMADSP
CCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCC
IHIGFISPHSHNFCHECNRVRVTVEGQLLLCLGNEHAVDLKSIVREFPADIERLKAAILA
EEEEEECCCCCCHHHCCCEEEEEECCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
GINLKPKQHDFGNNQVQILRFMNATGG
CCCCCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]