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The map label for this gene is proA [H]

Identifier: 160877526

GI number: 160877526

Start: 5229119

End: 5230366

Strand: Direct

Name: proA [H]

Synonym: Sbal195_4425

Alternate gene names: 160877526

Gene position: 5229119-5230366 (Clockwise)

Preceding gene: 160877525

Following gene: 160877527

Centisome position: 97.79

GC content: 49.12

Gene sequence:

>1248_bases
ATGAATTTAATCAAAAACTTATCTCAAGAAGCTGCCAAAGCGGCTCTTATTCTCGCCCAAGTTGATGAACAGCTTAAAAA
TACTGTACTCCTCGACATGGCGCGTTCATTACGTGAAAAGTCCTACGAAATCCAAAGCGCTAACTTGATTGACCTACACA
GAGCAACAGCCGATAACGTTGCCCCTGCTATGCTCGACCGCTTAACGTTAACGCCAGAACGCGTAGAAGCCATGGCAGTA
GGGATTGAAACCATCGCTGCCTTGCCCGATCCCATTGGCAATGAACGTTATATTGGTCAACGACCTAACGGTTTATCCAT
CAGCAAGATGCGCGTGCCATTAGGCGTGGTTTGTATGATTTATGAAGCGCGTCCGAATGTTACCGCCGATGCAGGTGCCC
TGTGCTTTAAATCCGGCAATGCCGTGATTTTGCGCGGTGGTAAAGAGGCGCTGCACACCAGCAAAATTATCGCCACCATT
TTGCAAAGTGTATTGAAACAATACGGCTTGCCCGAGGCGTTAATCACAGTGGTGCCCGATCCTGACCGTGCCCTGATGTT
GGAACTGATGCAGCAACGAGATTATATCGATGTGATCATTCCCCGTGGCGGCGAAGGCTTGATTAACTTTGTGTCTGACA
ACAGTAAAATCCCAGTGATCCAGCATTTTAAAGGCGTGTGTCATTTATACGTCGATAAAGATGCCGATCTGGATATTGCT
TTGGACTTACTGCTCAACGGTAAAACCCAGCGCACAGGCGTGTGTAATGCCCTCGAAGCCCTATTAGTGCACCAAGAAAT
TGCTTCGCAATTCCTGCCTAAAGTGGCCAAAGCGCTGGCCGAGCATAAGGTTAAAATCAATGCTTGTACCCAATCCGGTG
GCTACTTCGAAAACTGTACTTACATGGAAGAAGACGATTTCGGCCAAGAGTATTTAGATCTCGAAATCGCCATTCGCCAA
GTCGATCACTTCGACCATGCTATCCAACACATTGCCCGTTTTGGTAGCCAGCACACCGAAGTGATTTGCACCGAAAACGA
AGTCACAGCCGCACGCTTCCAACGTGCAGTCGATGCTTCTGTGGTAATGGTCAATGCCTCTTCGCGCTTCTCCGACGGCA
GCGAACTCGGCCTTGGTGCGGAAATCGGCATCGCCACCACTAAGCTACATGCCTATGGCCCAATGGGGCTCGAATCCTTG
ACCGCTGAGAAGTATTTAGTCTCAGGCACAGGCCAAGTACGGGCATAA

Upstream 100 bases:

>100_bases
GCAAAAGACTGGACCGATCATTTCCGAGAAAAACATCGCCATTCTCGAATAAGCATCAGCCGAATAAATATGAGCGAGTA
AACATCTAAGCGGAGTAAAT

Downstream 100 bases:

>100_bases
ACCGAGAATGTAAATCACACTTTTAGGCTTAATACGTCGGTTGGATTTCGATTCAATTGTAAAGATTAAAGGCCACAGTC
GGTAACGACTGTGGCCTTTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNLIKNLSQEAAKAALILAQVDEQLKNTVLLDMARSLREKSYEIQSANLIDLHRATADNVAPAMLDRLTLTPERVEAMAV
GIETIAALPDPIGNERYIGQRPNGLSISKMRVPLGVVCMIYEARPNVTADAGALCFKSGNAVILRGGKEALHTSKIIATI
LQSVLKQYGLPEALITVVPDPDRALMLELMQQRDYIDVIIPRGGEGLINFVSDNSKIPVIQHFKGVCHLYVDKDADLDIA
LDLLLNGKTQRTGVCNALEALLVHQEIASQFLPKVAKALAEHKVKINACTQSGGYFENCTYMEEDDFGQEYLDLEIAIRQ
VDHFDHAIQHIARFGSQHTEVICTENEVTAARFQRAVDASVVMVNASSRFSDGSELGLGAEIGIATTKLHAYGPMGLESL
TAEKYLVSGTGQVRA

Sequences:

>Translated_415_residues
MNLIKNLSQEAAKAALILAQVDEQLKNTVLLDMARSLREKSYEIQSANLIDLHRATADNVAPAMLDRLTLTPERVEAMAV
GIETIAALPDPIGNERYIGQRPNGLSISKMRVPLGVVCMIYEARPNVTADAGALCFKSGNAVILRGGKEALHTSKIIATI
LQSVLKQYGLPEALITVVPDPDRALMLELMQQRDYIDVIIPRGGEGLINFVSDNSKIPVIQHFKGVCHLYVDKDADLDIA
LDLLLNGKTQRTGVCNALEALLVHQEIASQFLPKVAKALAEHKVKINACTQSGGYFENCTYMEEDDFGQEYLDLEIAIRQ
VDHFDHAIQHIARFGSQHTEVICTENEVTAARFQRAVDASVVMVNASSRFSDGSELGLGAEIGIATTKLHAYGPMGLESL
TAEKYLVSGTGQVRA
>Mature_415_residues
MNLIKNLSQEAAKAALILAQVDEQLKNTVLLDMARSLREKSYEIQSANLIDLHRATADNVAPAMLDRLTLTPERVEAMAV
GIETIAALPDPIGNERYIGQRPNGLSISKMRVPLGVVCMIYEARPNVTADAGALCFKSGNAVILRGGKEALHTSKIIATI
LQSVLKQYGLPEALITVVPDPDRALMLELMQQRDYIDVIIPRGGEGLINFVSDNSKIPVIQHFKGVCHLYVDKDADLDIA
LDLLLNGKTQRTGVCNALEALLVHQEIASQFLPKVAKALAEHKVKINACTQSGGYFENCTYMEEDDFGQEYLDLEIAIRQ
VDHFDHAIQHIARFGSQHTEVICTENEVTAARFQRAVDASVVMVNASSRFSDGSELGLGAEIGIATTKLHAYGPMGLESL
TAEKYLVSGTGQVRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=406, Percent_Identity=36.4532019704434, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI21361368, Length=406, Percent_Identity=36.4532019704434, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=41.9664268585132, Blast_Score=333, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=34.2168674698795, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=34.2168674698795, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=35.4838709677419, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21357643, Length=379, Percent_Identity=36.9393139841689, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45262; Mature: 45262

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIKNLSQEAAKAALILAQVDEQLKNTVLLDMARSLREKSYEIQSANLIDLHRATADNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHCCCCCH
APAMLDRLTLTPERVEAMAVGIETIAALPDPIGNERYIGQRPNGLSISKMRVPLGVVCMI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEE
YEARPNVTADAGALCFKSGNAVILRGGKEALHTSKIIATILQSVLKQYGLPEALITVVPD
EECCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PDRALMLELMQQRDYIDVIIPRGGEGLINFVSDNSKIPVIQHFKGVCHLYVDKDADLDIA
CCHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCCEEE
LDLLLNGKTQRTGVCNALEALLVHQEIASQFLPKVAKALAEHKVKINACTQSGGYFENCT
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
YMEEDDFGQEYLDLEIAIRQVDHFDHAIQHIARFGSQHTEVICTENEVTAARFQRAVDAS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCE
VVMVNASSRFSDGSELGLGAEIGIATTKLHAYGPMGLESLTAEKYLVSGTGQVRA
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure
MNLIKNLSQEAAKAALILAQVDEQLKNTVLLDMARSLREKSYEIQSANLIDLHRATADNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHCCCCCH
APAMLDRLTLTPERVEAMAVGIETIAALPDPIGNERYIGQRPNGLSISKMRVPLGVVCMI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEE
YEARPNVTADAGALCFKSGNAVILRGGKEALHTSKIIATILQSVLKQYGLPEALITVVPD
EECCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PDRALMLELMQQRDYIDVIIPRGGEGLINFVSDNSKIPVIQHFKGVCHLYVDKDADLDIA
CCHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCCEEE
LDLLLNGKTQRTGVCNALEALLVHQEIASQFLPKVAKALAEHKVKINACTQSGGYFENCT
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
YMEEDDFGQEYLDLEIAIRQVDHFDHAIQHIARFGSQHTEVICTENEVTAARFQRAVDAS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCE
VVMVNASSRFSDGSELGLGAEIGIATTKLHAYGPMGLESLTAEKYLVSGTGQVRA
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA